Physiology and Technology Core

生理与技术核心

基本信息

批准号：
10090990
负责人：
Zhi-Zhou He
金额：
$ 15.38万
依托单位：
CREIGHTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-05 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090990
关键词：
Animal Model Auditory Auditory Brainstem Responses Auditory Evoked Potentials Auditory area Biochemistry Biological Models Biomedical Research Centers of Research Excellence Clinical Investigator Communication Communities Complex Consultations Core Facility Development Doctor of Medicine Doctor of Philosophy Electrophysiology (science)Elements Environment Equipment Experimental Models Faculty Family Fee-for-Service Plans Foundations Funding Gene Mutation Goals Hearing Human Image Individual Infrastructure Interdisciplinary Study Laboratory Research Larva Mass Spectrum Analysis Measures Mentors Methodology Midwestern United States Molecular Biology Neurosciences Phenotype Physics Physiology Play Principal Investigator Productivity Protocols documentation Research Research Personnel Research Project Grants Research Support Resources Role Science Scientist Services Structure Techniques Technology Universities Whole Organism Zebrafish design educational atmosphere hearing impairment instrument instrumentation medical schools mid-career faculty mouse model multidisciplinary otoacoustic emission outreach program professor response scientific atmosphere single molecule software development

项目摘要

PROJECT SUMMARY/ABSTRACT Auditory Vestibular Technology Core Core facilities are centralized shared research resources that provide access to instruments, technologies, as well as expert consultation and other services to scientific and clinical investigators. Core facilities are crucial for competitive multidisciplinary science and have become an integral part of biomedical research. The Auditory- Vestibular Technology (AVT) Core will be established to provide infrastructure to support Research Project Leaders and principal investigators associated with the Translational Hearing Center at Creighton University to conduct multidisciplinary auditory and vestibular research. We will achieve this goal by: 1) Providing state-of- the-art methodologies and instrumentation to faculty conducting auditory and vestibular studies in animal models. The AVT Core will provide state-of-the-art technical and scientific support for COBRE-supported translational auditory and vestibular researchers in the area of auditory and vestibular electrophysiology, molecular biology, imaging and mass spectrometry. The AVT Core will also provide the infrastructure necessary to capitalize on emerging technological developments. 2) Mentoring Core users in multidisciplinary research to successfully compete for research funding. To promote an interdisciplinary scientific environment within the Core itself, and among investigators in the region generally, the Core is dedicated to an intensive outreach program designed to encourage inter-investigator communication and introduce junior investigators to interdisciplinary methodologies available in the AVT Core. 3) Developing a sustainability plan to provide Core services for new and established investigators beyond COBRE funding. To meet this goal, an active outreach program will be implemented and a fee-for-service structure will be developed. The AVT Core will play an essential role to the establishment of multidisciplinary Translational Hearing Center by providing services to research projects that validate ototherapeutics. The core will also augment the intellectual and scientific atmosphere of the local and Midwest auditory research community, now and beyond COBRE support.

项目概要/摘要听觉前庭技术核心核心设施是集中共享的研究资源，提供仪器、技术、以及为科学和临床研究人员提供专家咨询和其他服务。核心设施至关重要竞争性多学科科学，并已成为生物医学研究的一个组成部分。听觉- 将建立前庭技术（AVT）核心，为支持研究项目提供基础设施克赖顿大学转化听力中心的领导者和主要研究人员进行多学科的听觉和前庭研究。我们将通过以下方式实现这一目标：1）提供state-of- 为在动物模型中进行听觉和前庭研究的教师提供最先进的方法和仪器。 AVT 核心将为 COBRE 支持的转化提供最先进的技术和科学支持听觉和前庭电生理学、分子生物学领域的听觉和前庭研究人员，成像和质谱分析。 AVT 核心还将提供必要的基础设施来利用新兴技术的发展。 2) 指导核心用户成功进行多学科研究争夺研究经费。促进核心内部的跨学科科学环境，以及在该地区的调查人员中，核心致力于开展密集的外展计划，旨在鼓励研究者之间的交流并向初级研究者介绍跨学科方法在 AVT 核心中可用。 3) 制定可持续发展计划，为新老企业提供核心服务 COBRE 资助之外的研究人员。为了实现这一目标，将实施积极的外展计划并将制定按服务收费的结构。 AVT核心将在建立多学科转化听力中心，为验证研究项目提供服务耳科疗法。该核心还将增强当地和中西部的知识和科学氛围听觉研究社区，现在以及超越 COBRE 支持。