The Nathan Schnaper Intern Program in Translational Cancer Research

内森·施纳珀 (Nathan Schnaper) 转化癌症研究实习生计划

• 批准号: 10089616
• 负责人: BRET A HASSEL
• 金额: $ 32.42万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10089616
• 关键词: Age-Years; Biological; Cancer Biology; Cancer Detection; Cancer Survivor; Cardiovascular Diseases; Career Choice; Caring; Cause of Death; Cessation of life; Clinical; Clinical Oncology; Comprehensive Cancer Center; Data; Detection; Educational Curriculum; Exposure to; Fostering; Funding; Goals; Grant; Health; Human; Institution; Internships; Joints; Laboratories; Learning Module; Malignant Neoplasms; Maryland; Mentors; Mission; Oncologist; Outcome; Patient-Focused Outcomes; Population; Population Sciences; Recording of previous events; Reporting; Research; Research Personnel; Scientist; Seminal; Talents; Training; Training and Education; Translational Research; Universities; Workforce Development; anticancer research; burden of illness; cancer education; cancer epidemiology; cancer risk; cancer therapy; career; clinical application; cohort; education pathway; education research; experience; fight against; innovation; interest; mortality; next generation; novel diagnostics; novel strategies; novel therapeutic intervention; novel therapeutics; peer networks; programs; recruit; success; survivorship; translational cancer research; translational pipeline; tumorigenesis; undergraduate student

Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it remains a major health concern that is predicted to surpass cardiovascular disease as the major cause of death in the US. by 2020. The growing segment of the population that is over 65 years of age and at elevated risk for cancer adds to this disease burden. These data highlight the need for new approaches to cancer treatment and its management in cancer survivors who are projected to exceed 20 million by 2026. Advances in our understanding of fundamental biological mechanisms that are disrupted in human cancers to promote oncogenesis have progressed at an unparalleled rate and provide a seedbed for the novel therapeutic interventions required to fill this need. The current challenge is to close this widening gap between laboratory discoveries and their clinical applications in the fight against cancer. Indeed, creating a streamlined translational pipeline is a priority of the Cancer Moonshot Initiative. Despite these unprecedented opportunities to impact patient outcomes, there is a shortage of young scientists and clinicians with a strong background in cancer biology and the demand for oncologists is predicted to outpace the supply of clinicians in this field by 2025. Thus, inspiring and training the next generation of cancer researchers and oncologists is central to accelerating the translation of research breakthroughs into new diagnostics and therapeutics. The Nathan Schnaper Intern Program in Translational Research (NISP) at the University of Maryland Greenebaum Comprehensive Cancer Center seeks to achieve this goal through three specific aims: 1) Recruit talented and diverse cohorts of undergraduate interns with an interest in cancer research and/or clinical oncology from institutions across the US. 2) Integrate mentored research, educational modules and clinical exposure to provide interns with hands-on experience in translational cancer research, excite them about careers in this field and foster their success on this path. 3) Evaluate program outcomes and disseminate this information to identify and share best practices, track the progress of intern alumni as a key metric of program success and develop capacity-building partnerships. The NSIP has a strong history of training interns who make seminal contributions to cancer biology. The current proposal builds upon this history, and successes of the first funding period, by augmenting a robust summer curriculum with innovative population science components. New modules in cancer epidemiology, disparities, and survivorship provide interns with a broader perspective of cancer research, care and career opportunities. Furthermore, as part of an expanded cancer education pipeline that is now comprised of nine programs, NSIP interns benefit from near peer networking through joint forums that inform and impact their educational and career path decisions. Incorporation of innovative new modules with established NSIP components in the next funding period will fulfill the research, education, training and workforce development goals of the Cancer Research Education Grants Program that are integral to the NCI mission.

检测和治疗方面的显着进展降低了癌症的死亡率；但是，超过170万 2019年报道的新病例和600,000例癌症死亡，这仍然是一个主要的健康问题 超过心血管疾病是美国的主要死亡原因。到2020年。 超过65岁且患癌症风险升高的人口增加了这种疾病负担。这些数据 强调需要对癌症治疗的新方法及其在癌症幸存者中的管理 预计到2026年，预计将超过2000万。 在人类癌症中受到破坏以促进肿瘤发生的情况以无与伦比的速度进展，并且 为满足这一需求提供新的治疗干预措施，提供苗床。当前的挑战是 弥合实验室发现与其在抗癌斗争中的临床应用之间的扩大差距。 确实，建立简化的翻译管道是癌症月光倡议的优先事项。尽管如此 前所未有的影响患者结局的机会，年轻的科学家和临床医生短缺 预计具有强大的癌症生物学背景和对肿瘤学家的需求将超过供应 到2025年，该领域的临床医生。因此，启发和训练下一代癌症研究人员和 肿瘤学家是将研究突破转化为新诊断和 疗法。 Nathan Schnaper实习计划（NISP） 马里兰州格林鲍姆综合癌症中心旨在通过三个特定目标来实现这一目标： 1）招募有才华和多样化的本科实习生，对癌症研究和/或 来自美国机构的临床肿瘤学。 2）整合受过指导的研究，教育模块和 临床暴露，为实习生提供转化癌研究方面的动手经验，使他们激动 这一领域的职业并在这条道路上促进了他们的成功。 3）评估计划结果并传播 信息以识别和共享最佳实践，跟踪实习生校友的进度作为计划的关键指标 成功并建立能力建立伙伴关系。 NSIP拥有培训实习生的悠久历史 对癌症生物学的开创性贡献。当前的提议建立在这一历史上，并取得了第一个的成功 资助期，通过使用创新的人口科学组成部分来增强健壮的夏季课程。新的 癌症流行病学，差异和生存的模块为实习生提供了更广泛的观点 癌症研究，护理和职业机会。此外，作为扩展的癌症教育管道的一部分 现在由九个计划组成，NSIP实习生通过联合论坛从附近的同行网络中受益 这为他们的教育和职业道路决策提供了信息和影响。与创新的新模块合并 在下一个资金期间成立的NSIP组件将满足研究，教育，培训和劳动力 癌症研究教育补助计划的发展目标是NCI任务不可或缺的。