Core C: Vulnerable Populations Core

核心 C：弱势群体核心

基本信息

批准号：
10090778
负责人：
Stephanie Hart Parade
金额：
$ 25.86万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090778
关键词：
Address Adult Behavioral Biological Centers of Research Excellence Child Childhood Clinical Communities Competence Data Development Disadvantaged Discrimination Disease Documentation Economics Educational workshop Environment Ethics Exposure to Faculty Goals Health Hospitals Individual Infrastructure Local Government Longevity Maintenance Medical Mental Health Outcome Population Population Heterogeneity Poverty Recording of previous events Relationship-Building Research Research Personnel Research Project Grants Resources Risk Risk Factors Services Sexual and Gender Minorities Socioeconomic Status State Government Stress Structure Symptoms Training Trauma Underserved Population Vulnerable Populations Work biobehavior childhood adversity clinically significant community partnership disadvantaged background diversity and equity ethnic minority population experience human subject human subject protection innovation marginalized population physical conditioning racial minority recruit resilience social exclusion social stigma success

Address Adult Behavioral Biological Centers of Research Excellence Child Childhood Clinical Communities Competence Data Development Disadvantaged Discrimination Disease Documentation Economics Educational workshop Environment Ethics Exposure to Faculty Goals Health Hospitals Individual Infrastructure Local Government Longevity Maintenance Medical Mental Health Outcome Population Population Heterogeneity Poverty Recording of previous events Relationship-Building Research Research Personnel Research Project Grants Resources Risk Risk Factors Services Sexual and Gender Minorities Socioeconomic Status State Government Stress Structure Symptoms Training Trauma Underserved Population Vulnerable Populations Work biobehavior childhood adversity clinically significant community partnership disadvantaged background diversity and equity ethnic minority population experience human subject human subject protection innovation marginalized population physical conditioning racial minority recruit resilience social exclusion social stigma success

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项目摘要

PROJECT SUMMARY / ABSTRACT The COBRE for Stress, Trauma, and Resilience (STAR) will establish a transformative, transdisciplinary Miriam Hospital research center focused on the biobehavioral mechanisms through which childhood stress, trauma, and adversity impact health outcomes across development. Childhood adversity is a major risk factor for physical and mental health problems across the lifespan, yet those with adverse exposures are highly likely to be underserved due to socioeconomic position. Children and adults from disadvantaged backgrounds, including racial and ethnic minorities, individuals living in poverty, and sexual minority and gender diverse populations are at substantially heightened risk of exposure to adversity. Further, although disadvantaged communities are most likely to experience adversity and trauma, they are often difficult to reach and engage in research as a result of societal discrimination, medical mistrust, marginalization, stigma, and economic and structural factors. Specialized infrastructure to address the practical, ethical, and clinical issues in research with vulnerable and underserved populations is critical for long-term success of the STAR COBRE. The Human Subjects and Vulnerable Populations (VP) Core will support the overall goals of the STAR COBRE by building critical infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories. In addition, because all three proposed research projects in this COBRE include data and biospecimens from human subjects, the VP Core will serve as a recommended hub for documentation and training related to human subjects’ protection for all components of the COBRE (PAR-19-313). The VP Core will provide resources and support targeted to developing capacity to successfully recruit and retain difficult to reach populations, while maintaining to standards in the ethical conduct of research with children and adults with stress and trauma histories. The VP Core will also provide support to enhance existing and build new community partnerships, and to increase competence of COBRE faculty and staff regarding issues of diversity, equity, and inclusion. The VP Core will be essential to the overall success of the STAR COBRE by providing critical expertise, services, and infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories.

项目摘要 /摘要压力，创伤和弹性的毛线（星星）将建立一个变革性的跨学科 Miriam医院研究中心重点介绍了童年压力的生物行为机制，创伤和广告影响整个发展的健康结果。儿童广告是主要风险因素对于整个生命周期中的身心健康问题，但暴露不良的人很可能由于社会经济的立场而服务不足。背景不安的儿童和成人，包括种族和少数民族，生活在贫困中的个人以及性别少数群体和性别潜水员人口大大增加了广告广告的风险。此外，尽管处于不利地位社区最有可能经历广告和创伤，他们通常很难接触和参与由于社会歧视，医学不信任，边缘化，污名和经济和经济和经济和经济的研究结构因素。专门的基础设施来解决研究中的实用，道德和临床问题由于易受伤害和服务不足的人群对于恒星柯布尔的长期成功至关重要。这人类受试者和脆弱人群（VP）核心将支持明星的整体目标通过建立关键的基础设施来支持临床意义和高度创新与弱势儿童和成人有关压力和创伤历史的研究。此外，因为所有人该杂核中的三个拟议的研究项目包括来自人类受试者的数据和生物测量。核心将作为与人类受试者有关的文档和培训的建议枢纽保护毛病的所有组件（Par-19-313）。 VP核心将提供资源和针对发展能力成功招募和保留难以到达人口的支持，同时在与有压力和成人的儿童和成年人进行研究的道德行为中保持标准创伤历史。 VP核心还将提供支持，以增强现有和建立新的社区合作伙伴关系，并提高山cor教职员工的能力，就多样性，公平，和包容。通过提供关键专业知识，服务和基础设施，以支持临床意义和高度创新的研究有压力和创伤历史的脆弱儿童和成人。