Project 3: Isolating food insecurity to understand childhood health outcomes and biological mechanisms of risk

项目 3：隔离粮食不安全以了解儿童健康结果和风险的生物机制

基本信息

批准号：
10090781
负责人：
E. Whitney Evans
金额：
$ 25.22万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090781
关键词：
Address Adherence Adipose tissue Adult Affect Age American Anemia Animal Model Anxiety Asthma Behavior Biological Biological Markers Blood specimen Body mass index C-reactive protein Calories Caregiver Burden Caregivers Centers of Research Excellence Child Child Health Childhood Chronic Disease Collection Communities Consumption Diet Disadvantaged Exposure to Fasting Fatty acid glycerol esters Food Food Services Foundations Glucose Glycosylated hemoglobin A Health Healthy Eating Hour Household Hydrocortisone Impairment Impulsivity Inflammation Inflammatory Insulin Insulin Resistance Interleukin-6 Intervention Leptin Lipids Low income Malnutrition Measures Mediating Mental Depression Mental Health Metabolic syndrome Minority Moods Nature Newsletter Nutrient Obesity Outcome Overweight Participant Poverty Prevention Price Problem behavior Prospective Studies Proteins Randomized Research Resources Rhode Island Risk Role Schools Secure Ships Stress Testing Time Training Trauma Unhealthy Diet United States Weight Gain Woman Work Youth adipokines adiponectin adverse childhood events age group anxiety symptoms base blood glucose regulation career childhood adversity cytokine depressive symptoms dietary disorder risk excessive weight gain experience food insecurity glucose metabolism health disparity indexing maternal depression novel nutrition obesity in children physical conditioning prevent primary endpoint programs prospective recruit resilience service programs social health determinants stress symptom sugar

项目摘要

PROJECT SUMMARY/ABSTRACT Food insecurity affects one in seven households with children in the United States and disproportionately impacts those headed by women and minorities. Food insecurity is associated with childhood obesity, asthma, anxiety and depression and behavioral problems, and thus contributes to health disparities. While food insecurity likely contributes to poor health through its effect on diet, such a simplistic understanding likely obscures the effects of stress – those unique to childhood, such as Adverse Childhood Experiences including maternal depression, as well as those generally associated with the experience of poverty. To inform the mechanisms by which food insecurity ultimately affects physical and mental health outcomes in children, this study will disentangle the effects of food insecurity from those of poverty and examine effects on diet, biomarkers, weight gain, mood and behavior while considering other childhood adversities. Specifically, through a unique summertime meal provision intervention, the proposed project will isolate the experience of food insecurity in children, ages 8-12 years, from low-income households in Providence, RI. In partnership with the YMCA of Greater Providence and the Healthy Communities Office in Providence, we will recruit 100 children over two summers. After completing a baseline assessment, participants will be randomized to the Food Insecure or Food Secure groups. Children randomized to the Food Insecure group will experience the natural onset of summertime food insecurity and receive a weekly newsletter on community resources that is not expected to affect food insecurity. Those randomized to the Food Secure group will remain food secure over the summer through receipt of weekly shipments of five breakfast and lunch meals that meet the nutrition needs of this age group. Primary endpoints include diet quality, biomarkers of Metabolic Syndrome, inflammation, and stress, BMI z-scores, and child measures of behavior and anxiety and depression symptoms. We will also explore the impact of caregiver mood and stress on the health effects of food insecurity. Ultimately, findings from this research will clarify the mechanisms by which food insecurity affects child health outcomes and inform how to more effectively prevent food insecurity. They will also provide the foundation for an R01 application and further training for Dr. Evans (PI) to establish an independent research career focused on understanding the role of diet in the prevention of health disparities in disadvantaged youth.

项目摘要/摘要粮食不安全影响七分之一的家庭，在美国有孩子，不成比例地影响妇女和少数民族领导者。粮食不安全与儿童对象，哮喘，焦虑，抑郁和行为问题，从而导致健康差异。食物不安全感可能会因对饮食的影响而导致健康状况不佳，这种简单的理解很可能掩盖了压力的影响 - 那些童年独有的压力，例如不利的童年经历孕产妇抑郁症以及通常与贫困经历有关的抑郁症。告知食物不安全感最终影响儿童身心健康的机制，这研究将使粮食不安全的影响与贫困和检查对饮食的影响的影响，在考虑其他童年逆境的同时，生物标志物，体重增加，情绪和行为。具体来说，通过独特的夏季餐食干预措施，拟议的项目将隔离来自RI普罗维登斯的低收入家庭，8至12岁的儿童的粮食不安全。与大普罗维登斯和普罗维登斯健康社区办公室的基督教青年会，我们将招募100 两个夏天的孩子。完成基线评估后，参与者将被随机分配给食品不安全或食品安全群体。随机分配给食品不安全的孩子将经历夏季粮食不安全的自然发作，并收到有关社区资源的每周通讯预计不会影响粮食不安全感。那些随机到食品安全的人群将保持食物的安全在夏天，每周收到五种早餐和午餐餐的货物，可以满足营养这个年龄段的需求。主要终点包括饮食质量，代谢综合征的生物标志物，炎症和压力，BMI Z得分以及行为和焦虑与抑郁的儿童度量症状。我们还将探讨护理人员情绪和压力对食物健康影响的影响不安全感。最终，这项研究的发现将阐明粮食不安全感影响的机制儿童健康结果并告知如何更有效地防止粮食不安全。他们还将提供为Evans博士（PI）建立独立研究的R01申请和进一步培训的基础职业专注于了解饮食在预防灾难遭受灾难的青年中的健康差异中的作用。