Spinal Cord Injury and Heat Acclimation

脊髓损伤和热适应

• 批准号: 7618020
• 负责人: Jonathan Wingo
• 金额: $ 1.63万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-08-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618020
• 关键词: Acclimatization; Accounting; Activities of Daily Living; Address; Affect; Blood Plasma Volume; Blood flow; Body Temperature; Cardiovascular system; Cessation of life; Climate; Coronary heart disease; Cross-Sectional Studies; Cutaneous; Data; Doctor of Philosophy; Environment; Exercise; Functional disorder; Goals; Heart Diseases; Heart Rate; Heat Stress Disorders; Heat Stroke; Heating; Immersion Investigative Technique; Impairment; Individual; Injury; Insulin Resistance; Lesion; Life Style; Literature; Longitudinal Studies; Microdialysis; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Performance; Persons; Physical Capacity; Physical activity; Physiologic Thermoregulation; Population; Protocols documentation; Risk; Sample Size; Severities; Skin; Spinal Cord Lesions; Spinal cord injury; Stimulus; Stress; Stroke Volume; Sweat; Sweating; Syncope; Techniques; Temperature; Testing; Travel; United States; Vasomotor; Water; Work; base; cardiovascular disorder risk; coping; exhaustion; experience; fitness; improved; novel; response

DESCRIPTION (provided by applicant): Impaired thermoregulation in individuals with a spinal cord lesion can result in elevated cardiovascular and thermal strain during exercise, which may discourage these individuals from participating in regular physical activity, especially that occurring in a warm environment. Physical inactivity increases the risk of developing several morbidities, including coronary heart disease, Type II diabetes, and obesity. Heat acclimation may improve thermal tolerance of spinal cord injured (SCI) individuals, thereby enabling greater comfort during exercise and day-to-day heat stresses, such as outdoor exposures during summer months. The main objective of the proposed project is to test the hypothesis that the degree of thermal impairment in individuals with SCI will be related to the level of the injury and that individuals with SCI can counteract impaired thermoregulation by acclimating to a hot environment. Specific aim 1: Test the hypothesis that in individuals with a spinal cord lesion, the severity of vasomotor and sudomotor function impairments is related to lesion level. Specific aim 2: Test the hypothesis that individuals with SCI can counteract impaired thermoregulation by acclimating to a hot environment, which will 1) improve sweating and skin blood flow, 2) result in lower core body temperature during a given thermal challenge, 3) and result in lower cardiovascular strain (lower heart rate and higher stroke volume) during exercise. Specific aim 1 will be accomplished by conducting a cross-sectional study of differences in thermal and cardiovascular responses between individuals with high and individuals with low spinal cord lesions, as well as able-bodied individuals. Novel techniques will be used to assess expected differences and associated mechanisms. Specific aim 2 will be accomplished by conducting a longitudinal study of the effects and mechanisms of heat acclimation in individuals with SCI.

描述（由申请人提供）：患有脊髓损伤的个体的体温调节受损可能会导致运动期间心血管和热应变升高，这可能会阻碍这些个体参加定期的体育活动，尤其是在温暖的环境中进行的体育活动。缺乏身体活动会增加罹患多种疾病的风险，包括冠心病、II 型糖尿病和肥胖症。热适应可以提高脊髓损伤（SCI）个体的热耐受性，从而在运动和日常热应激（例如夏季户外暴露）期间提供更大的舒适度。该项目的主要目标是检验以下假设：SCI 患者的热损伤程度与损伤程度相关，并且 SCI 患者可以通过适应炎热环境来抵消体温调节受损的情况。具体目标 1：检验以下假设：在脊髓病变个体中，血管舒缩和催汗功能损伤的严重程度与病变程度相关。具体目标 2：检验以下假设：SCI 患者可以通过适应炎热环境来抵消体温调节受损的情况，这将 1) 改善出汗和皮肤血流量，2) 在给定的热挑战期间导致较低的核心体温，3) 和导致运动期间较低的心血管压力（较低的心率和较高的每搏输出量）。具体目标 1 将通过对高脊髓损伤个体和低脊髓损伤个体以及身体健全个体之间的热和心血管反应差异进行横断面研究来实现。新技术将用于评估预期差异和相关机制。具体目标 2 将通过对 SCI 个体热适应的影响和机制进行纵向研究来实现。