Aging Animal Models and Longevity Assessment Core

衰老动物模型和长寿评估核心

基本信息

批准号：
10260624
负责人：
JAMES FLOYD NELSON
金额：
$ 15.68万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-15 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10260624
关键词：
Address Adrenal Gland Hyperfunction Age Aging Animal Experimentation Animal Model Animals Applications Grants Autophagocytosis Biological Biology Biology of Aging Callithrix Callithrix jacchus jacchus Caloric Restriction Cells Consultations Continuity of Patient Care Data Data Analyses Data Collection Development Disease Dissection Documentation Education Four Core Genotypes Funding Gender Generations Goals Health Inflammation Intervention Intervention Studies Kidney Knowledge Leadership Longevity Maintenance Mammals Manuscripts Measurable Measures Mission Modeling Mole Rats Molecular Monitor Mus Nutritional Pathologic Pharmaceutical Preparations Pharmacology Phase Phenotype Physiological Play Preparation Process Publications Rattus Recording of previous events Reproducibility Research Research Personnel Resources Rodent Rodent Model Role Sampling Services Sex Differences Shock Skeletal Muscle Study models Tissues Training United States National Institutes of Health Work age effect age related animal tissue base cost effective design dietary genotypic sex healthspan human female in vivo innovation interest life history mouse model nerve stem cell nonhuman primate novel programs protective effect sex sexual dimorphism sound tool

项目摘要

The Aging Animal Models and Longevity Assessment Core (Animal Core) will continue a nearly 25 year history of leadership, service, training and innovation in 1) providing new and established aging animal models, 2) administering nutritional and pharmacologic interventions, and 3) collecting lifespan and life-history data for investigators in San Antonio and across the nation. The Animal Core is an essentail pillar of the San Antonio (SA) Shock Center's overarching mission - to provide investigators with the resources required to integrate lifespan and pathologic data with physiologic (healthspan) and molecular aging phenotypes for the expansion of knowledge on the biology of aging and the identification of pharmacological and nutritional targets to promote heathy aging. The Core achieves its goals through the following Specific Aims: 1) To breed and age new and established investigator-driven rodent models to elucidate mechanisms of aging. 2) To conduct lifespan studies of genetically, nutritionally, and pharmacologically manipulated mice and rats. 3) To provide aging marmosets to facilitate research on mechanisms of aging in non-human primates. 4) To educate and advise investigators on the requirements for rigor and reproducibility in aging animal research. The Core is housed in facilities specifically designed for the exclusive husbandry of aging animals. It provides exceptional continuity of care and data collection by highly trained staff. It is the only Core providing access to aging mice, rats, naked-mole rats and a non-human primate model, the common marmoset. Over the past 5 years, the Animal Core has continued its history of providing services to many investigators across the nation, supporting multiple grant applications and publications, and contributing to impactful advances in the biology of aging including: a) identification of the first murine model of the human female survival advantage; b) discovery of the protective effect of calorie restriction on aging neural stem cells; c) demonstration of a central role for hyperadrenocorticism in the suppression of inflammation by calorie restriction; d) discovery of a causal role of H2S generation on kidney aging in mice; and e) establishing the first interventional lifespan extension study with a pharmacologic agent in marmosets. These and other advances enabled by the Animal Core underscore its importance as a generator of biogerontologic discovery.

老化的动物模型和寿命评估核心（动物核心）将继续将近25年领导，服务，培训和创新的历史1）提供新的和已建立的衰老动物模型， 2）管理营养和药理学干预措施，以及3）收集寿命和寿命数据圣安东尼奥和全国各地的调查人员。动物核心是圣安东尼奥的精华尾柱（SA）Shock Center的总体任务 - 为调查人员提供整合所需的资源具有生理学（HealthSpan）和分子老化表型的寿命和病理数据关于衰老生物学以及鉴定药理和营养靶标的知识希西衰老。核心通过以下特定目的实现其目标： 1）繁殖新的和建立的研究者驱动的啮齿动物模型，以阐明衰老的机制。 2）进行遗传，营养和药理操纵小鼠和大鼠的寿命研究。 3）提供衰老的摩尔果，以促进非人类灵长类动物衰老机制的研究。 4）教育和向研究人员提供有关衰老动物研究的严格和可重复性的要求。该核心位于专门为衰老动物的独家饲养的设施中。它提供训练有素的员工的护理和数据收集的出色连续性。它是唯一提供访问权限的核心衰老的小鼠，大鼠，裸摩尔大鼠和非人类灵长类动物模型，即常见的果果。在过去的5个多年来，动物核心一直在为全国许多调查人员提供服务的历史，支持多个赠款申请和出版物，并为生物学的有影响力进步做出贡献衰老包括：a）鉴定人类女性生存优势的第一个鼠模型； b）发现卡路里限制对衰老神经干细胞的保护作用； c）演示核心角色在卡路里限制抑制炎症时，高肾上腺皮质主义； d）发现H2S的因果作用小鼠肾脏衰老的产生； e）通过 Marmosets的药理学剂。这些和其他由动物核心实现的进步强调了作为生物生产学发现的发生者的重要性。