Characterization of Marmosets as a Geroscience Model by the San Antonio MAP

圣安东尼奥 MAP 将狨猴描述为老年科学模型

• 批准号: 10260420
• 负责人: Corinna Nicole Ross
• 金额: $ 45.83万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260420
• 关键词: Acarbose; Address; Affect; Aftercare; Age; Aging; Animal Experimentation; Animal Model; Animals; Area; Basic Science; Biological; Biological Assay; Biological Markers; Biology; Body Composition; Brain; Callithrix; Cardiovascular system; Cell Aging; Cell physiology; Chronology; Cognition; Cognitive; Disease; Education; Educational workshop; Effectiveness; Elderly; Environment; Etiology; Foundations; Funding; Gene Expression; Geroscience; Goals; Health; Human; Individual; Inflammation; Institution; Interdisciplinary Study; Intervention; Intervention Studies; Kidney; Laboratory Animals; Leadership; Link; Liver; Longevity; Metabolic; Metabolism; Metformin; Methods; Mitochondria; Modeling; Molecular; Outcome; Pathologic; Pharmacologic Substance; Pharmacology; Phenotype; Physiological; Population; Pre-Clinical Model; Preclinical Testing; Primates; Research; Research Personnel; Resources; Rodent; Sampling; Sirolimus; Syndrome; Testing; Time; Tissue Banks; Translations; Work; age effect; age related; aged; anti aging; clinical application; experience; functional decline; functional outcomes; high risk; interdisciplinary approach; interest; model development; next generation; nonhuman primate; pre-clinical; programs; resilience; response; tool; translation to humans

In response to RFA-AG-20-007, we address the FOA to “facilitate the characterization of the marmoset as a laboratory animal for research on aging and age-related diseases” by leveraging the expertise and resources of the San Antonio Marmoset Aging Program (SA MAP). Over the last decade, the SA MAP has made major contributions to our understanding of the physiological and functional changes that occur in aging marmosets including physiological (metabolism, body composition, etc.), functional (cognitive, cardiovascular, etc.), pathological and molecular. Moreover, the SA MAP is at the forefront of using the marmoset for geroscience and has directed studies to address the effect of aging interventions on marmoset lifespan. The SA MAP has built an interactive group of researchers from different backgrounds to take interdisciplinary approaches to address fundamental questions that exist in the changes that occur with age in the marmoset and to meet our overarching goal to characterize and provide a marmoset resource for geroscience research. Characterization of the marmoset for geroscience, particularly in terms of the hallmarks of aging will provide a valuable preclinical model for translation with explicit definitions on how aging affects identifiable physiological, pathological and cellular/molecular outcomes. Moreover, the marmoset will be a valuable preclinical tool for testing potential intervention strategies in terms of pharmacology, their effects of age-related health and even their effects on longevity in the marmoset prior to human translation. The rationale for this work is that utilization of functional assays will identify biomarkers that can be linked to phenotypic syndromes of aging. Building on our strengths, we will also test the extent to which anti-aging interventions affect outcomes of these functional assays to identify whether they can be utilized as metrics of aging in marmosets. Perhaps most importantly, the SA MAP resources able to be devoted to this study are unmatched elsewhere; the SA MAP maintains ~100 aged and geriatric (from 5-18 yr) marmosets as well as banks of tissue (e.g., kidney, liver, brain) collected from animals across the age range. Our first aim is to elucidate and establish the extent to which chronological marmoset age affects the hallmarks of aging. Our second aim is to determine the extent to which short-term anti-aging interventions alter hallmarks of aging and functional phenotypes in the marmoset to strengthen the foundation for marmosets in geroscience. Our third aim is to expand the synergistic interdisciplinary research team to further develop cutting-edge research. By building synergistic research relationships, it is anticipated that funding of this proposal will both elucidate research findings regarding the marmoset model in geroscience as well as develop the next generation of cutting-edge research using this animal.

为了回应RFA-AG-20-007，我们通过利用San Antonio Marmoset Aging Program（SA Map）的专业知识和资源（SA Map）的专业知识和资源来解决FOA“促进Marmoset作为实验室衰老和与年龄相关疾病的实验室动物的表征”。在过去的十年中，SA地图为我们对衰老的摩尔群体发生的身体和功能变化做出了重大贡献，包括物理（代谢，身体组成等），功能（认知，心血管等），病理学和分子。此外，SA地图是使用Marmoset进行Geroscience的最前沿，并指示研究以解决衰老干预措施对Marmoset寿命的影响。 SA地图建立了来自不同背景的互动式研究人员，以采用跨学科的方法来解决Marmoset年龄发生的变化中存在的基本问题，并实现我们的总体目标，以表征和为Geroscience Research提供Marmoset资源。摩尔莫斯特（Marmoset）的geroscience表征，特别是在衰老的标志方面，将为翻译提供有价值的临床前模型，并具有有关衰老如何影响可识别的生理，病理和细胞/分子结果的明确定义。此外，Marmoset将是一种有价值的临床前工具，用于测试药理学，与年龄相关的健康的影响，甚至它们对人类翻译之前毛摩斯群岛寿命的影响。这项工作的理由是，功能测定法的利用将确定可以与衰老的表型综合症相关的生物标志物。在我们的优势的基础上，我们还将测试抗衰老干预措施影响这些功能测定结果的程度，以确定它们是否可以用作摩尔马斯群岛的衰老指标。也许最重要的是，可以将SA地图资源专用于这项研究，在其他地方无与伦比。 SA地图维持了约100个老年和老年（从5-18年）以及从整个年龄段收集的动物收集的组织（例如肾脏，肝脏，脑）的组织（例如肾脏，肝脏，脑）。我们的第一个目的是阐明和确定年龄段年龄影响衰老标志的程度。我们的第二个目的是确定短期抗衰老干预措施在多大程度上改变了摩尔摩斯特咖啡中衰老和功能表型的标志，以增强果冻在Geroscience中的基础。我们的第三个目标是扩大协同跨学科研究团队，以进一步发展尖端研究。通过建立协同的研究关系，可以预料，该提案的资金既可以阐明有关Geroscience中Marmoset模型的研究结果，又要阐明使用该动物的下一代尖端研究。