DO ORAL CONTRACEPTIVES CAUSE WEIGHT GAIN?

口服避孕药会导致体重增加吗？

• 批准号: 7715993
• 负责人: ALISON B EDELMAN
• 金额: $ 2.77万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715993
• 关键词: Adverse effects; Animals; Body Weight; Body Weight decreased; Canis familiaris; Computer Retrieval of Information on Scientific Projects Database; Estrogens; Failure; Felis catus; Funding; Goals; Grant; Institution; Monkeys; Mus; Oral Contraceptives; Ovary; Primates; Progesterone; Rate; Rattus; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; Weight Gain; Weight maintenance regimen; Woman; experience; unintended pregnancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This grant explores the effect of oral contraceptives on body weight control in adulthood. Many women stop taking oral contraceptives because they are concerned about a perceived side effect, weight gain. But this failure to consistently take oral contraceptives leads to increased rates of unintended pregnancy. Surprisingly, studies in animals (mice, rats, cats, dogs, monkeys) have shown that estrogen and progesterone administration to ovariectomized animals generally leads to weight loss, rather than weight gain. The overall goal of this grant is to document changes in body weight when ovary-intact primates are given oral contraceptives for a one year period of time. We hypothesize that monkeys taking oral contraceptives for a year with not experience weight gain, but may in fact experience a mild weight loss; a finding which would discredit the perceived side effect of oral contraceptives in causing weight gain.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 这笔赠款探讨了口服避孕药对成年期体重控制的影响。 许多女性停止服用口服避孕药，因为她们担心副作用，即体重增加。但未能持续服用口服避孕药会导致意外怀孕率增加。令人惊讶的是，对动物（小鼠、大鼠、猫、狗、猴子）的研究表明，对切除卵巢的动物施用雌激素和黄体酮通常会导致体重减轻，而不是体重增加。 这笔赠款的总体目标是记录卵巢完整的灵长类动物服用口服避孕药一年后的体重变化。 我们假设，服用口服避孕药一年的猴子并未出现体重增加，但事实上可能会出现轻微的体重减轻；这一发现将质疑口服避孕药导致体重增加的副作用。