Administrative Core

行政核心

基本信息

批准号：
10251963
负责人：
JUDITH A JAMES
金额：
$ 19.88万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-07 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10251963
关键词：
Address Adult Advisory Committees Aging Aliquot Applications Grants Area Autoantibodies Autoimmune Diseases Autoimmunity Biomedical Engineering Blood Vessels Cardiology Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Coagulation Process Code Collection Communication Communities Connective Tissue Diseases Couples Custom Data Databases Dermatology Development Development Plans Disease Distant Endocrinology Ensure Epidemiologist Evaluation Eye Financial Support Fostering Freezing Funding Gene Expression Profiling Genetic Genetic Research Genotype Genus Capra Geriatrics Goals Grant Health Hematology Human Human Resources Hypersensitivity Immunologist Immunology Indigenous Inflammation Information Systems Institutes Institution Investigation Investments Leadership Manuscripts Mediator of activation protein Mentors Minority Participation Mission Molecular Monitor NCI Scholars Program Oklahoma Oncology Participant Pathogenesis Patient Selection Patients Phenotype Pilot Projects Policies Precision therapeutics Prevention Procedures Program Evaluation Publications Publishing Qualitative Evaluations Quantitative Evaluations Research Research Personnel Research Project Grants Resources Rheumatism Rheumatology Role Sampling Secure Series Services Shock Sjogren&apos s Syndrome Suggestion Surveys Systemic Lupus Erythematosus Technology Testing Training Translational Research Undifferentiated United States National Institutes of Health Update Visit Work base biobank career career development clinically relevant effectiveness evaluation interdisciplinary approach interest meetings minority investigator molecular pathology molecular phenotype multidisciplinary new technology online resource outreach patient subsets phenotypic data programs recruit symposium systems research tribal community user-friendly

项目摘要

ORDRCC Administrative Core Project Summary The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) facilitates collaborative rheumatic disease research, provides cutting-edge technologies to address new clinically-relevant questions, recruits investigators with other interests/training to rheumatic disease investigation and fosters development of junior investigators to independent rheumatic disease research careers. With 25 local Center Investigators, 11 Junior Center Investigators (local), 11 Junior Center Investigators (distant) and a new Scholar program to develop early stage investigators committed to rheumatic disease investigation, the ORDRCC Administrative Core serves as the central communications hub and information conduit to accomplish the expanded ORDRCC mission to provide detailed, individualized information for each study patient to allow investigators to select homogeneous, mechanistic-driven subsets of patients for studies of pathogenesis, prediction, prevention and precision treatment of SLE, Sjogren’s, UCTD and related disorders. The ORDRCC will enhance the career development of junior investigators and expand rheumatic disease research through a multi-pronged Rheumatic Disease Clinical Research Enrichment Program which includes a weekly seminar series, visiting lectureships, and a new Expanding Rheumatic Disease Colloquium held in conjunction with a new group each quarter to explore new areas of collaborative research, such as with the Reynolds Center on Aging, OU Bioengineering, Dean McGee Eye Institute, and others. Additional outreach communication to community- based partners and tribal communities is also planned. The Administrative Core will enhance communication through new online resources, listserves and updates; provide management through developed policies and procedures for oversight and optimization of resource utilization, prioritizing service to junior center investigators and Scholars; and develop a new Proposal Development Center within the Administrative Core to help junior center investigators and Scholars to prepare and submit manuscripts and competitive grant applications. The Core also assists Junior Center Investigators and Scholars with regulatory compliance oversight. The ORDRCC has a historically vibrant pilot project program which has launched the independent careers of 16 junior investigators who have gone on to receive over $20M in independent external grant support. This Core will continue to offer this program which couples modest financial support with prioritized Core resources, focused mentoring and a career development plan. The Administrative Core also serves as the nidus for interactions with the Advisory Committee to ensure that suggestions are reviewed and implemented. The ORDRCC has implemented a rigorous qualitative and quantitative tracking and evaluation program evaluation which helps to monitor and maximize resource utilization and scientific discoveries. These qualitative surveys also help to set strategic Center priorities, prioritize phenotyping services and new technologies to evaluate and identify the patient collections which need expansion or further enhancement.

ORDRCC 行政核心项目概要俄克拉荷马州风湿病研究核心中心 (ORDRCC) 促进协作风湿病疾病研究，提供尖端技术来解决新的临床相关问题，招募对风湿病调查有其他兴趣/接受过培训的调查人员，并促进初级人员的发展拥有 25 名当地中心研究人员，其中 11 名初级研究人员。中心调查员（本地）、11 名初级中心调查员（远程）和一个新的学者计划待开发致力于风湿病调查的早期研究人员，ORDRCC 行政核心 ORDRCC 充当中央通信枢纽和信息管道，以完成扩大的 ORDRCC 使命是为每个研究患者提供详细的、个性化的信息，以便研究人员进行选择均质的、机械驱动的患者子集，用于研究发病机制、预测、预防和 ORDRCC 对 SLE、干燥症、UCTD 和相关疾病的精准治疗将提升职业生涯。培养初级研究者并通过多管齐下扩大风湿病研究风湿病临床研究丰富计划，包括每周一次的研讨会系列、访问讲座，以及与每个新小组联合举办的新的扩展风湿病研讨会季度探索合作研究的新领域，例如与俄勒冈大学雷诺兹老龄化中心生物工程、迪恩·麦吉眼科研究所等与社区进行额外的外展沟通。行政核心也将加强沟通。通过新的在线资源、列表服务和更新，通过制定的政策和服务提供管理；监督和优化资源利用的程序，优先为青少年中心提供服务研究人员和学者；并在行政核心内建立一个新的提案开发中心帮助初级中心研究人员和学者准备和提交手稿和竞争性资助核心还协助初级中心研究人员和学者遵守法规。 ORDRCC 有一个历来充满活力的试点项目计划，该计划已经启动了独立的监管。 16 名初级研究人员的职业生涯，他们后来获得了超过 2000 万美元的独立外部资助该核心将继续提供该计划，该计划将适度的财政支持与优先考虑相结合。核心资源、重点指导和职业发展计划也是行政核心。与咨询委员会互动的根源，以确保建议得到审查和 ORDRCC 实施了严格的定性和定量跟踪和评估。项目评估有助于监测和最大化资源利用和科学发现。定性调查还有助于确定中心的战略优先事项、优先考虑表型服务和新的服务评估和识别需要扩展或进一步增强的患者集合的技术。