Biomedical Informatics, Bioinformatics and Cyberinfrastructure Enhancement Core

生物医学信息学、生物信息学和网络基础设施增强核心

• 批准号: 10252030
• 负责人: Mary Helen Mays
• 金额: $ 19.37万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-02 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10252030
• 关键词: Acute; Bioinformatics; Cardiometabolic Disease; Caribbean region; Caring; Clinical; Clinical Data; Clinical Research; Clinical Trials; Communicable Diseases; Communities; Conduct Clinical Trials; Continuing Education; Data; Data Collection; Development; Disasters; Disease; Education; Effectiveness; Electronic Health Record; Emerging Communicable Diseases; Environment; Face; Goals; Health; Health Insurance Portability and Accountability Act; Health Personnel; Health Status; Healthcare; Hispanics; Hospitals; Individual; Informatics; Infrastructure; Institution; Knowledge; Language; Lead; Malignant Neoplasms; Maps; Medical; Medicine; Online Systems; Outcome; Participant; Pathway interactions; Population; Positioning Attribute; Public Health Informatics; Puerto Rican; Puerto Rico; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rural Community; Secure; Services; Source; System; Technology; Training; Training Programs; Training and Education; Translational Research; Urban Community; Work; base; bilingualism; biomedical informatics; clinical care; clinical data warehouse; cyber infrastructure; data infrastructure; data mining; data warehouse; design; drug efficacy; electronic data; experimental study; field study; health care delivery; health data; improved; informatics tool; innovation; interdisciplinary approach; medically underserved; monitoring device; population health; programs; recruit; research study; routine care; support tools; tool; translational scientist; volunteer; web portal; web site

Abstract/Summary Our understanding of individual and population health status, including the development of innovative approaches to disease identification and treatment, is increasingly based on the availability and analyses of real- world data (RWD) collected from environments where routine care is provided (e.g., electronic health records (EHRs), claims and billing activities). When consolidated into clinical research data warehouses (CRDWs), RWD become a critical source for medical data mining supporting clinical research/trials, as well as informing healthcare in all facets of medicine. The goal of the Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core (BiBEC) is to strengthen and expand the tools and resources that supply real world data specific to Hispanic populations, and develop programs that prepare skilled informaticians. In addition, BiBEC is committed to increasing knowledge in biomedical informatics, bioinformatics, and health informatics so that clinicians as well as clinical and translational researchers are informed consumer of said services, understanding their applications in both clinical care and research environments. The central hypothesis of the aims presented here is that informatics tools, and the necessary resources to fully utilize these tools, can advance health and healthcare at all nodes along the clinical and translational research pathway. The specific aims of BiBEC are to: 1) strengthen and expand existing health data infrastructure to improve clinical care and best practices (electronic health records/clinical research data warehouse), 2) enhance the availability and recruitment opportunities of Puerto Rican and other Hispanic populations into clinical and translational research studies using technology-based innovations, and 3) develop training for clinicians and clinical and translational researchers which will enable their use and application of available biomedical, bioinformatic, and health informatics-related data and technologies. The innovation of BiBEC includes: 1) an operational, secure clinical research data warehouse; 2) bilingual website that proactively supports the promotion of clinical trial opportunities, with a community-facing web portal, where individuals may register as a volunteer in clinical trials; 3) FISMA and HIPAA-compliant web-based data collection tools; and 4) training and continuing education in biomedical informatics, health informatics, and bioinformatics that helps clinicians and clinical researchers be informed consumers of biomedical and bioinformatics information and tools.

摘要/总结 我们对个人和人口健康状况的了解，包括创新药物的开发 疾病识别和治疗的方法越来越依赖于真实数据的可用性和分析 从提供日常护理的环境中收集的世界数据（RWD）（例如电子健康记录 （电子病历）、索赔和计费活动）。当整合到临床研究数据仓库 (CRDW) 中时，RWD 成为支持临床研究/试验以及提供信息的医疗数据挖掘的关键来源 医学各个方面的医疗保健。生物医学信息学、生物信息学和生物医学信息学的目标 网络基础设施增强核心（BiBEC）旨在加强和扩展提供网络基础设施的工具和资源 特定于西班牙裔人口的真实世界数据，并开发培养熟练信息学家的计划。在 此外，BiBEC 致力于增加生物医学信息学、生物信息学和健康方面的知识 信息学，以便临床医生以及临床和转化研究人员了解消费者的情况 服务，了解其在临床护理和研究环境中的应用。中央 这里提出的目标假设是信息学工具以及充分利用这些工具的必要资源 工具，可以促进临床和转化研究路径上所有节点的健康和医疗保健。这 BiBEC 的具体目标是： 1) 加强和扩展现有的健康数据基础设施，以改善临床 护理和最佳实践（电子健康记录/临床研究数据仓库），2）增强可用性 波多黎各人和其他西班牙裔人口进入临床和转化的招募机会 使用基于技术的创新进行研究，3）为临床医生和临床和 转化研究人员将能够使用和应用现有的生物医学、生物信息学、 以及与健康信息学相关的数据和技术。 BiBEC的创新包括：1）一个可操作的、 安全的临床研究数据仓库； 2）积极支持临床推广的双语网站 试验机会，有一个面向社区的门户网站，个人可以在其中注册为临床志愿者 试验； 3) 符合 FISMA 和 HIPAA 的基于网络的数据收集工具； 4）培训和继续教育 生物医学信息学、健康信息学和生物信息学领域，帮助临床医生和临床研究人员 向消费者通报生物医学和生物信息学信息和工具。