Pathways to Cancer Therapeutics

癌症治疗途径

• 批准号: 10241347
• 负责人: Vinita Takiar
• 金额: $ 52.75万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241347
• 关键词: Malignant Neoplasms; Pathway interactions; Therapeutic

Project Summary The opportunities for new and targeted approaches to cancer treatment are growing at an exponential pace. However, to effectively harness these opportunities requires a pool of researchers who can bridge the divide between lab-based identification of new therapeutic approaches and actual clinical needs and practicalities of patient treatment. Currently the pool of individuals with such skills is limited. The Pathways to Cancer Therapeutics Training Program seeks to address this shortfall by increasing the number of individuals with a strong training in the areas of cancer biology that underlie identification of new therapeutic approaches, who also have a true understanding of the challenges and needs associated with translating scientific discovery into the clinic. The Training Program has two key goals: The first is to provide pre- and postdoctoral trainees with a rigorous and applied understanding of how basic research in cancer biology can be utilized to identify new drug targets and more effective therapeutic strategies. The second is to provide the trainees with an understanding of the challenges and practice of using cancer therapeutics in the clinic. The training will focus on three areas that are key to development of new therapeutic approaches and are areas of institutional strength in cancer therapy: cancer metabolism, tumor immunology and the microenvironment, and genome instability and regulation. A series of multidisciplinary activities are proposed to achieve the goals of the Program. (1) Trainees will participate in a mentored research project under the direction of one of 26 primary mentors who come from 10 basic science and clinical departments across the University of Cincinnati (UC) and Cincinnati Children’s Medical Center (CCHMC). The mentors have active, well-funded research programs and extensive mentoring experience. (2) Trainees undertake formal training that includes didactic coursework, attending seminars, ethics training and career development activities. The specialized classes lead to a Certificate in Clinical and Translational Research. (3) Trainees participate in activities in clinical oncology. Each trainee is paired with a clinical co-mentor with expertise related to the trainee’s research area. The clinical co-mentor participates in the development of the trainee research project and career plan. In addition, trainees attend Tumor Boards/Grand Rounds and participate in clinical shadowing experiences with their co-mentor. The Training Program is administered by Co-Principal Investigators and a Clinical Director with support from business offices within UC. Three administrative committees provide program evaluation and oversight, support a rigorous trainee selection process, ensure excellence in training, monitor trainee progress and ensure that trainees represent an ethnically and scientifically diverse group. There is a strong institutional commitment to the Training Program in the form of direct financial support, trainee benefits and administrative support. Institutional programs and Training Program mentors and trainees are actively involved in recruitment of underrepresented groups. The Training Program requests support from the NIH for 6 postdoctoral and 2 predoctoral trainees.

项目概要 新的、有针对性的癌症治疗方法的机会正在呈指数级增长。 然而，要有效利用这些机会，需要一批能够弥合分歧的研究人员 基于实验室的新治疗方法鉴定与实际临床需求和实用性之间的关系 目前，具有此类技能的患者数量有限。 治疗培训计划旨在通过增加患有这种疾病的人数来解决这一不足 在癌症生物学领域进行了强有力的培训，这是确定新治疗方法的基础，他们还 真正了解将科学发现转化为现实的挑战和需求 培训计划有两个关键目标：第一个是为博士前和博士后学员提供培训。 对如何利用癌症生物学基础研究来识别新药进行严格和应用的理解 第二是让学员了解目标和更有效的治疗策略。 培训将重点介绍在临床中使用癌症疗法的挑战和实践。 这是开发新治疗方法的关键，也是癌症领域的机构优势领域 治疗：癌症代谢、肿瘤免疫学和微环境、基因组不稳定性和 提出了一系列多学科活动来实现该计划的目标 (1) 受训人员。 将参加一个由来自 26 位主要导师之一指导的研究项目 辛辛那提大学 (UC) 和辛辛那提儿童医院的 10 个基础科学和临床系 医学中心 (CCHMC) 的导师拥有活跃、资金充足的研究项目和广泛的指导。 (2) 学员接受正式培训，包括教学课程、参加研讨会、道德培训 培训和职业发展活动。专业课程可授予临床和职业证书。 (3) 学员参加临床肿瘤学活动。 具有与受训者研究领域相关的专业知识的临床共同导师 临床共同导师参与该培训。 学员研究项目和职业计划的制定 此外，学员参加肿瘤委员会/盛大。 与他们的共同导师一起查房并参加临床见习体验。 由联合首席研究员和临床主任在 UC 内业务办公室的支持下管理。 三个管理委员会提供项目评估和监督，支持严格的学员选拔 过程，确保培训的卓越性，监控受训者的进展并确保受训者代表种族 和科学多元化的团体对培训计划有强有力的机构承诺。 直接财政支持、实习生福利和行政支持。 项目导师和学员积极参与代表性不足群体的招募工作。 该项目请求 NIH 为 6 名博士后和 2 名博士前实习生提供支持。