High Glycemic Diet and Alzheimer's Risk

高血糖饮食与阿尔茨海默病风险

• 批准号: 10240718
• 负责人: Matthew Taylor
• 金额: $ 13.07万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10240718
• 关键词: Acute Disease; Address; Adherence; Advanced Development; Advisory Committees; Affect; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease risk; Amyloid; Amyloid deposition; Area; Assessment tool; Behavior; Blood flow; Brain; Brain imaging; Burn injury; Carbohydrates; Cerebrovascular Circulation; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical assessments; Cognition; Cognitive; Collection; Complex; Data; Dementia; Development; Diabetes Mellitus; Diet; Dietary Assessment; Dietary Intervention; Dietary intake; Dietetics; Disease; Disease Progression; Elderly; Fat-Restricted Diet; Funding; Future; Goals; Health; Immersion; Impairment; Individual; Influentials; Infrastructure; Insulin Resistance; Intervention; Kansas; Knowledge; Lead; Learning; Link; Magnetic Resonance Imaging; Measures; Mediating; Medical center; Mediterranean Diet; Mentored Research Scientist Development Award; Mentors; Mentorship; Metabolic syndrome; Metabolism; Methodology; Methods; Modeling; Neurosciences; Nutritional; Nutritional Science; Nutritional Study; Outcome; Participant; Pattern; Peripheral; Personal Satisfaction; Prevention strategy; Preventive; Process; Prognosis; Public Health; Recommendation; Research; Research Methodology; Research Personnel; Risk Marker; Role; Scientist; Spectrum Analysis; Standardization; Structure; Techniques; Testing; Therapeutic; Training; Translational Research; United States National Institutes of Health; Universities; Work; aging brain; base; brain health; career; cognitive neuroscience; cognitive performance; cognitive testing; cohort; design; dietary; dietary adherence; effective therapy; experience; glucose metabolism; innovation; metabolic profile; neuroimaging; novel; nutrition; prevent; professor; ranpirnase; skills; sugar; tenure track; theories; therapy development; tool; training opportunity

PROJECT SUMMARY/ABSTRACT This K01 award will be integral in the development of my career plan designed to extend my prior training in nutrition and nutrition interventions to include skills in clinical assessment of dementia, Alzheimer’s disease (AD) research methods, cognitive theory and assessment, and metabolism themed MR neuroimaging tools. My previous training briefly introduced me to AD research and confirmed that I am passionate about a career in AD. Nutrition research in AD is a young and promising field that will require nutrition experts to gain extensive training to understand AD and its assessment tools. To this end, I’ve assembled an expert mentor and advisory committee to provide formal training in AD clinical assessment, cognition, and MR neuroimaging. I was appointed as an Assistant Professor on the Tenure Track in the KUMC Department of Dietetics and Nutrition on September 22, 2019. I will take advantage of KUMC’s interdisciplinary culture and train under the mentorship of Drs. Jeff Burns, Munro Cullum, and William Brooks. This will allow me to capitalize on several of KUMC’s research strengths: the NIH-designated KU Alzheimer’s Disease Center (ADC), Hoglund Brain Imaging Center, KUMC Department of Dietetics and Nutrition, and the Clinical and Translational Science Unit (funded through an NIH CTSA). Dr. Cullum will provide valuable external institutional training in AD research and cognition at UT Southwestern in Dallas, TX. The proposed K01 training will add to my well-developed nutrition skillset and forge a path toward my overall goal to establish research independence in the field of Nutritional Cognitive Neuroscience applying nutrition interventions and the neuroimaging and cognitive tools learned in this K01 to AD research. The scientific goals of this project are to build upon my doctoral research investigating nutrition’s role in AD risk. This is a growing field as current treatments for the disease are relatively ineffective and means for preventing its development are highly sought after. I propose to build off of my previous work showing high glycemic diet’s relationship with brain amyloid and investigate its relationship with AD risk using the tools acquired from the training in this K01. Aim 1 will leverage a clinical cohort (P30 AG035982) of over 450 participants at the University of Kansas Alzheimer’s Disease Center (KU ADC). This aim seeks to investigate the cross-sectional relationship of high glycemic diet with cognition and MR-derived brain structure and blood flow in older adults with and without AD. Aim 2 will leverage an NIA-funded R01 (AG060157-01) study at KUMC investigating the role of Mediterranean diet vs. low-fat diet interventions in AD prevention. The goal of this aim is to investigate whether intervention-related changes in high glycemic diet explain changes in cognition and MR-derived brain structure and metabolic profile. This aim will also explore whether the relationship between high glycemic diet and brain health outcomes is mediated by changes in glucoregulation, as assessed by insulin resistance scores.

项目摘要/摘要 该K01奖将在我的职业计划制定中不可或缺，旨在扩展我的先前培训 在营养和营养干预措施中，包括痴呆症临床评估的技能，阿尔茨海默氏病 （AD）研究方法，认知理论和评估以及代谢为主题的神经成像工具。 我以前的培训简要介绍了我进行广告研究，并确认我对职业充满热情 在广告中。广告中的营养研究是一个年轻而有前途的领域，需要营养专家才能获得 广泛的培训以了解广告及其评估工具。为此，我组装了专家导师 和咨询委员会，以提供广告临床评估，认知和神经影像学先生的正式培训。 我被任命为KUMC饮食学系的任期和助理教授 营养于2019年9月22日。我将利用KUMC的跨学科文化，并在 博士的遗产。杰夫·伯恩斯（Jeff Burns），芒罗·库鲁姆（Munro Cullum）和威廉·布鲁克斯（William Brooks）。这将使我能够利用几个 KUMC的研究优势：NIH指定的KU阿尔茨海默氏病中心（ADC），Hoglund Brain KUMC饮食与营养部以及临床和转化科学部门成像中心 （通过NIH CTSA资助）。 Cullum博士将在广告研究中提供宝贵的外部机构培训 和德克萨斯州达拉斯的UT西南部的认知。拟议的K01培训将增加我发达的 营养技能和朝着我的整体目标建立了在该领域建立研究独立性的道路 采用营养干预措施以及神经影像学和认知工具的营养认知神经科学 在此K01中学到了广告研究。 该项目的科学目标是在我的博士研究基础上研究营养在 广告风险。这是一个增长的领域，因为目前对该疾病的治疗相对无效，并且用于 防止其发展受到高度伤痕。我建议建立以前的工作表现高的作品 血糖饮食与脑淀粉样蛋白的关系，并使用工具调查其与AD风险的关系 从此K01的培训中获得。 AIM 1将利用堪萨斯大学的450多名参与者的临床队列（P30 AG035982） 阿尔茨海默氏病中心（KU ADC）。该目标旨在调查高高的横截面关系 具有和没有AD的老年人的认知和MR衍生的大脑结构和血流的血糖饮食。 AIM 2将利用NIA资助的R01（AG060157-01）在KUMC研究 地中海饮食与预防AD的低脂饮食干预措施。这个目的的目的是调查是否 高血糖饮食中与干预相关的变化解释了认知和MR衍生的大脑结构的变化 和代谢剖面。这个目标还将探索高血糖饮食与大脑之间的关系 通过胰岛素抵抗评分评估，健康结果是由葡萄糖调节的变化介导的。