Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.

在农药喷洒点附近长大的儿童的农药接触、心理健康和内分泌紊乱。

• 批准号: 10267166
• 负责人: Georgia L. Kayser
• 金额: $ 15.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10267166
• 关键词: 6 year old; Acetylcholine; Acetylcholinesterase; Address; Adolescent; Adrenal hormone preparation; Affect; Aftercare; Agriculture; Americas; Anxiety; Area; Attention; Attentional deficit; Australia; Award; Behavior; Biological; Biological Markers; Biological Monitoring; Biometry; Blood; California; Child; Child Development; Child Welfare; Cholinesterase Inhibitors; Chronic; Complex; Data; Diet; Ecuador; Endocrine Disruptors; Endocrine disruption; Environmental Health; Environmental Pollution; Estradiol; Etiology; Exposure to; Family Practice; Funding; Goals; Gonadal Steroid Hormones; Health; Hormones; Household; Hydrocortisone; Insecticides; Institution; Intervention; Irrigation; Language; Longitudinal Studies; Measures; Mediation; Memory; Mental Depression; Mental Health; Methodology; Modeling; Modification; Muscarinic Acetylcholine Receptor; National Institute of Environmental Health Sciences; Nicotinic Receptors; Occupational Exposure; Organophosphates; Outcome; Parents; Pathway interactions; Pattern; Performance; Pesticides; Physiological Processes; Physiology; Pilot Projects; Prevention; Production; Public Health; Quality of life; Research; Research Activity; Research Personnel; Risk; Schools; Site; Source; Students; Surface; Surveys; Techniques; Testing; Testosterone; Time; Toxic effect; Training; Training Activity; United States; Universities; Visuospatial; Water; Water Pollution; Work; agricultural community; career; career development; cohort; dehydroepiandrosterone; drinking; drinking water; executive function; exposure pathway; field study; follow-up; health assessment; improved; medical schools; neurobehavior; neurobehavioral; neurotoxicity; novel; pesticide exposure; professor; prospective; school health; sex; skills; spatiotemporal; therapy design; urinary

Pesticides pose a public health risk to children living in agricultural communities. Children are particularly vulnerable to the chronic effects of environmental contaminants such as insecticides, due to their size, physiology and behavior. Worldwide, the two most widely used classes of insecticides are cholinesterase inhibitors (organophosphates) and neonicotinoids. While some of the risks of organophosphates are known, to date, there are no longitudinal studies of neurobehavioral or mental health outcomes in adolescents related to spatial patterns of exposure to organophosphates and neonicotinoids. There is also no known research on the associated neurobehavioral health alterations from neonicotinoid exposures in drinking or irrigation water. The proposed study will leverage the parent, NIEHS-funded, longitudinal study of Secondary Pesticide Exposures among Children and Adolescents (ESPINA), that examined 313 children (4-6 years old) in 2008, who live near one of the highest concentrations of floriculture in the Americas, 535 adolescents in 2016, and is planning for a subsequent examination in 2020. The proposed K01 will integrate biological monitoring, household survey, and neurobehavioral examination data and utilize geospatial models and complex statistical techniques to: (1) disentangle pathways of pesticide exposure, (2) study the geospatial determinants of neurobehavioral performance (attention, memory, language, sensorimotor and visuospatial) and outcomes (anxiety and depression) in children and adolescents from pesticide exposure, (3) test pesticide exposure in drinking water and irrigation sources in proximity to floriculture. This is an application for a NIEHS Transition to Independent Environmental Health Research (TIEHR) Career Award for Dr. Georgia Kayser, an early career Environmental Health Assistant Professor in the Department of Family Medicine and Public Health in the School of Medicine at the University of California, San Diego. Dr. Kayser aims to establish herself as an independent environmental health investigator in the areas of pesticide exposure in children and adolescents and associated neurobehavioral outcomes and expand her water and health research to include pesticides in drinking and irrigation water. The award will provide Dr. Kayser with the support to achieve her career development goals: (1) to develop advanced methodological skills in biostatistics and geospatial analysis; (2) to advance training on child development and the interpretation and analysis of neurobehavioral assessment; (3) to acquire skills in spatiotemporal analysis of pesticide exposure data and neurobehavioral outcomes, (4) identify points of intervention and prevention to reduce pesticide exposure in children living in agricultural areas, (5) gain independence. The research and training activities outlined here will generate new research to inform the design of an intervention to be evaluated in an R01, and the application will be completed in year three of this award. This award will also build a strong research network between the United States (USCD) and Ecuador (USFQ).

农药对居住在农业社区的儿童构成公共卫生风险。儿童尤其是 由于其大小，生理学的大小 和行为。在全球范围内，使用的两种最广泛的杀虫剂是胆碱酯酶抑制剂 （有机磷酸盐）和新烟碱类似。迄今已知有机磷酸盐的一些风险 与空间相关的青少年的神经行为或心理健康结果没有纵向研究 暴露于有机磷酸盐和新烟碱的模式。也没有关于 饮酒或灌溉水暴露于新烟素暴露中的相关神经行为的健康改变。这 拟议的研究将利用父母，NIEHS资助的继发性农药暴露的纵向研究 在儿童和青少年（ESPINA）中，在2008年检查了313名儿童（4-6岁），他们住在附近 美洲花卉养殖浓度最高之一，2016年有535名青少年，正在计划 随后在2020年进行检查。拟议的K01将整合生物监测，家庭调查和 神经行为检查数据，并利用地理空间模型和复杂的统计技术为：（1） （2）研究神经行为的地理空间决定因素 表现（注意，记忆，语言，感觉运动和视觉空间）和结果（焦虑和 抑郁症）儿童和青少年暴露于农药，（3）饮用水中的农药暴露 和灌溉来源，靠近花卉文化。这是Niehs过渡到独立的应用 乔治亚·凯瑟（Georgia Kayser）博士的环境健康研究（TIEHR）职业奖，这是一个早期职业环境 医学院家庭医学和公共卫生系的健康助理教授 加州大学圣地亚哥分校。凯耶博士旨在将自己确立为独立的环境 儿童和青少年农药暴露领域的健康研究者以及相关的 神经行为的结果并扩大她的水和健康研究，以包括饮酒和 灌溉水。该奖项将为凯耶博士提供实现她职业发展目标的支持：（1） 发展生物统计学和地理空间分析方面的先进方法论技巧； （2）提前培训 儿童发展以及神经行为评估的解释和分析； （3）获得技能 农药暴露数据和神经行为结果的时空分析，（4）识别点 干预和预防以减少居住在农业地区儿童的农药暴露，（5） 独立。这里概述的研究和培训活动将产生新的研究以告知设计 将在R01中评估的干预措施，该申请将在本奖项的第三年完成。 该奖项还将在美国（USCD）和厄瓜多尔（USFQ）之间建立强大的研究网络。