Pennington MoTrPAC Adults

彭宁顿 MoTrPAC 成人

• 批准号: 10265138
• 负责人: Tuomo Rankinen
• 金额: $ 3.59万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265138
• 关键词: 21 year old; Abdomen; Acute; Adipose tissue; Adult; Aerobic; Aerobic Exercise; African American; Back; Biological; Biology; Biomedical Research; Biopsy; Blood; Body Composition; Caucasians; Cell Culture Techniques; Clinical Trials; Collection; Control Groups; Data; Development; Disease; Enrollment; Equipment; Exercise; General Population; Genetic; Goals; Health; Health Promotion; Heart Rate; Heritability; Heterogeneity; Human; Individual; Individual Differences; Intervention; Intervention Trial; Life Style; Lifting; Maps; Measures; Molecular; Morbidity - disease rate; Multicenter Studies; Muscle; Muscle Fibers; Participant; Pathway interactions; Performance; Physical activity; Population Heterogeneity; Positioning Attribute; Randomized; Randomized Clinical Trials; Recommendation; Regimen; Research; Research Personnel; Resistance; Rest; Risk Factors; Running; Sampling; Scheme; Skeletal Muscle; Specimen; Sports; Supervision; Testing; Training; Training Programs; Transducers; Translational Research; Vision; Walking; active control; aged; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; design; exercise intervention; exercise training; experience; healthy lifestyle; improved; intervention participants; mortality; muscle strength; novel; precision medicine; programs; recruit; resistance exercise; response; sample collection; sedentary; skills; strength training; success; treadmill; treatment arm; vigorous intensity; volunteer

PROJECT SUMMARY ABSTRACT A considerable body of evidence shows that exercise training induces multiple beneficial changes in cardiometabolic risk factors and that physically active individuals have lower mortality and morbidity rates than their sedentary counterparts. However, there are marked inter-individual differences in the responsiveness to regular physical activity with some individuals showing great benefits while others do not. While the response heterogeneity is clearly genetically determined, little is known about the molecular pathways and mechanisms that contribute to the adaptation to acute exercise and exercise training. The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to “understand the molecular changes that occur in response to physical activity”. We therefore propose to conduct a randomized clinical trial in which we will collect biological samples (blood, skeletal muscle and adipose tissue) before and after a 12-week aerobic or resistance training program in healthy, sedentary individuals. In addition, we will collect samples before, during and after a single bout of exercise at baseline and after training. We will also collect biosamples in highly trained athletes involved in endurance or strength sports. The overarching goal of the program is to contribute to the development of a molecular map of transducers that underlie the effects of physical activity. To achieve this goal, investigators at the Pennington Biomedical Research Center propose to: 1) Enroll and randomize 518 healthy, but sedentary volunteers (50% Caucasians, 47.5% African Americans, 2.5% others; aged 21-75 y; BMI 20-40 kg/m2) in a 3/3/1 scheme to a 12-week intervention trial comprised of two exercise groups, aerobic (AER) and resistance (RES) training, and a control group (CON). The goal is to have 178 completers in each training group and 60 in the CON group (20% attrition). 2) Recruit and enroll 50 athletes (ATH) competing in endurance (n=25) and strength (n=25) sports to serve as an active control group. The ATH group will undergo baseline testing and an acute bout of exercise consistent with their normal training regimen with similar pre- and post-acute exercise samples collection. The AER program will start at 3 days per week of treadmill walking/running progressing to 4 days per week by week 2 with an initial moderate intensity (heart rate associated with 50% VO2peak), then increasing to a more vigorous intensity (HR 75% VO2peak) by week 6. The RES program will be performed 3 days per week and consist of 9 exercises on Universal Gym Equipment, including four upper body lifts, three lower body lifts, abdominal crunch, and back extensions. The RES program will progress from 2 sets of 10-20 repetitions to 3 sets of 8-10 repetitions after week 2. All AER and RES exercise sessions will be conducted under strict supervision by trained staff. Because of the expertise in training studies and translational research as well as the availability of state-of-the-art facilities, Pennington investigators are well positioned to recruit/retain a diverse population, conduct the proposed trial and collect/store the necessary biosamples.

项目摘要 抽象的 大量证据表明，运动训练会引起多个有益的变化 心脏代谢危险因素，身体活跃的个体的死亡率和发病率低于 他们久坐的对手。但是，对响应能力有明显的个体间差异 与某些人的定期体育锻炼表现出很大的好处，而另一些人则没有。而回应 异质性在遗传上明确确定，对分子途径和机制知之甚少 这有助于适应急性运动和运动训练。分子传感器的目标 体育活动联盟（MOTRPAC）是“了解响应于 因此，身体活动”。因此，我们建议进行一项随机临床试验，我们将收集生物学 在12周或耐药性训练之前和之后，样品（血液，骨骼肌和脂肪组织） 健康，久坐的人的计划。此外，我们将在一次，之中和之后收集样本 基线和训练后的运动。我们还将在训练有素的运动员中收集生物样本 参与耐力或力量运动。该计划的总体目标是为 开发具有体育锻炼影响的传感器的分子图。 为了实现这一目标，Pennington生物医学研究中心的调查员提出了： 1）注册和随机分配518个健康但久坐的志愿者（50％高加索人，47.5％的非洲人 美国人，其他2.5％的人； 21-75岁； BMI 20-40 kg/m2）在3/3/1方案中进行12周干预试验 完成了两个运动组，有氧运动（AER）和电阻（RES）训练，以及一个对照组（CON）。 目的是在每个培训组中有178个完成者，在CON组中有60个（20％的损耗）。 2）招募和招募50名运动员（ATH）参加耐力（n = 25）和力量（n = 25）运动 作为一个主动对照组。 ATH组将接受基线测试和急性锻炼 与他们的正常训练方案一致，并在急性后运动样本中采集了类似的训练方案。 AER计划将以每周3天的跑步机行走/跑步开始，每周4天 第2周具有最初的中等强度（与50％vo2peak相关的心率），然后增加到一个 到第6周，强度强度（HR 75％VO2PEAK）。RES计划将每周进行3天，并且 包括在通用健身器材上进行的9种练习，包括四个上身升降机，三个下半身升降机， 腹部紧缩和后部延伸。 RES程序将从2组10-20次重复到3套 第2周之后的8-10次重复。 受过训练的员工的监督。由于培训研究和翻译研究的专业知识以及 最先进的设施的可用性，彭宁顿的调查人员在招募/保留A的位置良好 多样化的人群，进行拟议的试验并收集/存储必要的生物样本。