Translational Nanobiology Approaches to SARS-CoV2

SARS-CoV2 的转化纳米生物学方法

• 批准号: 10262558
• 负责人: Jennifer Jones
• 金额: $ 16.37万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10262558
• 关键词: 2019-nCoV; Area; CCR; COVID-19; COVID-19 pandemic; Collaborations; Collection; Communities; Detection; Disease; Flow Cytometry; Immunity; Immunology; Infection; Intention; Laboratories; Malignant Neoplasms; Methods; Molecular Analysis; Monitor; National Institute of Neurological Disorders and Stroke; Patients; Proteins; Protocols documentation; RNA; Research; Research Personnel; Resources; Technology; Testing; United States National Institutes of Health; Update; Viral; Virus; Work; exosome; extracellular vesicles; nano; nanobiologic; nanobiology; programs; tool; web site

Specific Aim 1: Test NCI Translational Nanobiology technologies for use in the study of SARS-CoV2 and COVID-19. By utilizing a BSL-2+ area for NIH N-VITA studies in the NINDS Viral Immunology Section, and by testing specialized tools and methods developed in the NCI Translational Nanobiology Section to facilitate ultra-sensitive detection of protein and RNA cargo in the viruses and in COVID-19 associated extracellular vesicles, we seek to advance characterization of both SARS-CoV2 viruses and Extracellular Vesicle (EV) repertoires from patients with COVID-19. Specific Aim 2: Establish a publicly accessible collection of protocols and tools for EV and Viral flow cytometry via our section website, nano.ccr.cancer.gov. Our intention with this effort is to establish an open-access resource at nano.ccr.cancer.gov wherein all protocols and methods for virus and EV detection or characterization that is developed in this NIH N-VITA program will be shared with the worldwide research community. Since launch of the website, we have been posting updates on a near-weekly basis.

特定目的1：测试NCI转化纳米生物学技术用于SARS-COV2和COVID-19的研究。 By utilizing a BSL-2+ area for NIH N-VITA studies in the NINDS Viral Immunology Section, and by testing specialized tools and methods developed in the NCI Translational Nanobiology Section to facilitate ultra-sensitive detection of protein and RNA cargo in the viruses and in COVID-19 associated extracellular vesicles, we seek to advance characterization of both SARS-CoV2 viruses and Extracellular Vesicle （EV）Covid-19患者的曲目。具体目标2：通过我们的部分网站Nano.ccr.cancer.gov建立了公共访问的EV和病毒流式细胞仪的协议和工具集合。我们的意图是在nano.ccr.cancer.gov上建立开放式资源，其中该NIH N-VITA计划中开发的所有病毒和EV检测或表征的所有方案和方法都将与全球研究社区共享。自网站启动以来，我们一直在每周发布更新。