Smartphone phenotype collection for diagnostic screening of mild cognitive impairment

智能手机表型收集用于轻度认知障碍的诊断筛查

基本信息

批准号：
10255750
负责人：
Steven L Armentrout
金额：
$ 118.66万
依托单位：
PARABON NANOLABS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10255750
关键词：
3-Dimensional Adult Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease model Amyloid Apple COVID-19 CTF1 gene Cellular Phone Clinic Clinical Cognition Cognitive Collection Computer Vision Systems Cyclophosphamide Data Data Collection Data Set Dementia Detection Development Disease Early Diagnosis Early Intervention Episodic memory Equipment Evaluation Eye Movements Face Fingers Frequencies General Practitioners Genetic Risk Goals Health Home Impaired cognition Impairment Individual Infrastructure Institutional Review Boards Intervention Journals Language Lewy Body Disease Machine Learning Manuscripts Measurement Measures Medical Device Mind Modeling Monitor Motion Motor Movement Neurologist Neuropsychological Tests Neuropsychology Paper Participant Patient Monitoring Patients Peer Review Performance Periodicity Phase Phenotype Production Publications Reading Reporting Research Resolution Saccades Scanning Sensitivity and Specificity Signal Transduction Small Business Innovation Research Grant Stream Surveys Tablets Test Result Testing Thumb structure Time Tremor Validation Vision Visit Voice Work World Health Organization arm base cloud platform cognitive ability cognitive change cognitive performance cognitive testing cohort commercialization design diagnostic screening digital digital health early screening experience functional decline handheld mobile device home test improved innovation mild cognitive impairment mobile application negative affect novel peace performance tests recruit risk prediction model screening sensor smartphone Application touchscreen tv watching usability visual search visual tracking

项目摘要

PROJECT SUMMARY In this Phase II SBIR project, Parabon NanoLabs will complete the development, validation and commercialization of CTX, a revolutionary smartphone- and tablet-based cognitive testing platform for collection and analysis of measurements of cognitive performance (“phenotypes”). Traditionally, cognitive assessments are performed in a clinic using either simple surveys that assess only some aspects of cognition or expensive, single-purpose equipment such as eye tracking stations. Such testing lacks the frequency and precision needed to detect subtle early changes that signal the onset of mild cognitive impairment (MCI) or early-symptomatic dementia. Instead, CTX will take full advantage of mobile sensors (e.g., audio, video, touchscreen, and motion) to enable in-depth cognitive testing anytime, anywhere. Regular use of CTX will allow a clearer picture of each user's cognitive abilities to emerge, enabling early detection of subtle changes. CTX is not intended to replace neurologists but instead to extend their reach by allowing regular, widespread screening for improved disease detection and patient monitoring. The long-range goal of CTX is to allow aging adults to monitor and manage their cognitive health more effectively and to provide pre-symptomatic indicators of pending dementia to patients and their clinicians, thus enabling early intervention and planning. After a highly successful Phase I project, CTX already enables rapid development of mobile tests that can capture raw sensor streams in a synchronized fashion and transmit them to a cloud server for subsequent analysis and reporting. Sophisticated analytics pipelines have been developed to convert these sensor streams into cognitive phenotypes (e.g., extracting eye movement data from selfie video taken during a cognitive test). Using the CTX framework, the Parabon team has already developed an Apple® iOS® mobile app with proof-of-principle tests for assessing verbal recall, eye movement, motor function, and episodic memory. In Phase II, we propose to develop two new suites of CTX tests for one-time cognitive impairment screening and cognitive performance monitoring, as well as phenotype extraction pipelines for each. We will evaluate tests in normal and affected cohorts to determine usability, user retention and whether resulting phenotypes enable accurate cognitive assessments by clinicians. Our specific aims are to (1) Develop new and engaging cognitive tests and pipelines for assessing visual search and targeting, expressive and receptive language, motor movement and episodic memory; (2) Validate measures in cognitively normal and impaired cohorts; and (3) Analyze and prepare data for publication and premarket submissions to the FDA.

项目概要在这个第二阶段 SBIR 项目中，Parabon NanoLabs 将完成开发、验证和 CTX 的商业化，一种革命性的基于智能手机和平板电脑的认知测试用于收集和分析认知表现（“表型”）测量值的平台。传统上，认知评估是在诊所使用简单的调查进行的，仅评估认知的某些方面或昂贵的单一用途设备，例如眼动追踪此类测试缺乏检测细微早期变化所需的频率和精度。相反，这是轻度认知障碍（MCI）或早期症状性痴呆发作的信号。 CTX 将充分利用移动传感器（例如音频、视频、触摸屏和运动）随时随地进行深入的认知测试定期使用 CTX 将让您的认知更清晰。每个用户的认知能力的图片都会出现，从而能够及早发现 CTX 的细微变化。并不是要取代神经科医生，而是通过允许定期、广泛筛查以改善疾病检测和患者监测。 CTX 的目的是让老年人更有效地监测和管理他们的认知健康向患者及其追随者提供待定痴呆症的症状前指标，从而实现早期干预和规划。在一期项目取得巨大成功之后，CTX 已经实现了移动测试的快速开发可以以同步方式捕获原始传感器流并将其传输到云服务器已开发出复杂的分析管道来进行后续分析和报告。将这些传感器流转换为认知表型（例如，从 Parabon 团队使用 CTX 框架在认知测试期间拍摄的自拍视频。已经开发了一款 Apple® iOS® 移动应用程序，其中包含用于评估言语能力的原理验证测试回忆、眼球运动、运动功能和情景记忆。在第二阶段，我们建议开发两套新的 CTX 测试，用于一次性认知障碍筛选和认知表现监测，以及表型提取管道我们将评估正常组和受影响组的测试，以确定可用性和用户保留率。以及由此产生的表型是否能够让我们的牧师进行准确的认知评估。具体目标是 (1) 开发新的、有吸引力的认知测试和管道来评估视觉搜索和瞄准、表达性和接受性语言、运动和情景记忆； (2) 验证认知正常和受损群体的测量结果；(3) 分析和准备；向 FDA 发布和上市前提交的数据。