Infrastructure Improvements for the Sabana Seca Field Station of the Caribbean Pr

加勒比项目 Sabana Seca 现场站的基础设施改善

• 批准号: 7630746
• 负责人: Janis A. Gonzalez-Martinez
• 金额: $ 50万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-04 至 2013-03-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7630746
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Biomedical Research; Breeding; Caribbean region; Development; Elements; Funding; Genetic Status; Grant; Institution; Macaca mulatta; Monkeys; Operative Surgical Procedures; Output; Primates; Provider; Research; Research Infrastructure; Research Personnel; Research Project Grants; Testing; Vaccine Research; Water; animal care; nonhuman primate; prevent; programs; reproductive; therapeutic vaccine

DESCRIPTION (provided by applicant): For 38 years the Caribbean Primate Research Center (CPRC) has been supporting high-quality, productive research by providing high-quality rhesus macaques for research initiatives of National importance. During the past 8 years, the CPRC provided over 1,300 monkeys to PHS and NIH-sponsored biomedical research programs supporting over $142 million in federal grants. Over $76 million of this amount was for AIDS-related and vaccine research initiatives. The CPRC is the second largest SPF colony in the Nation, and one of the largest SPF rhesus macaque providers for AIDS related research projects. In order to maintain quality animal care standards and comply with regulatory agencies, the CPRC needs to renovate critical elements of the infrastructure support facilities at the Sabana Seca Field Station. Funds from this application will be used for the following: 1) upgrade of the electrical infrastructure, 2) renovation of the primary deep-water well and 3) renovation of animal enclosures. We foresee the increased need for non-human primates for testing newly developed therapeutics and vaccines, and our concern is that the lack of an adequate infrastructure could prevent the development of the animal care program and research initiatives at the CPRC. The proposed improvements will enhance the rhesus monkey breeding operation and this will result in an increase of the reproductive output of the colony. This will in turn assure that more Indian-origin rhesus macaques of defined virological and genetic status are made available to NIH-funded researchers and institutions.

描述（由申请人提供）：38 年来，加勒比灵长类动物研究中心 (CPRC) 一直通过为国家重要的研究计划提供高质量的恒河猴来支持高质量、富有成效的研究。在过去的 8 年里，CPRC 向 PHS 和 NIH 资助的生物医学研究项目提供了 1,300 多只猴子，支持了超过 1.42 亿美元的联邦拨款。其中超过 7600 万美元用于艾滋病相关和疫苗研究计划。 CPRC 是美国第二大 SPF 群体，也是艾滋病相关研究项目最大的 SPF 恒河猴提供者之一。为了维持高质量的动物护理标准并遵守监管​​机构的要求，CPRC 需要翻新 Sabana Seca 野外站基础设施支持设施的关键要素。该申请的资金将用于以下目的：1）升级电力基础设施，2）改造主要深水井，3）改造动物围栏。我们预计对非人类灵长类动物测试新开发的疗法和疫苗的需求将会增加，我们担心缺乏足够的基础设施可能会阻碍 CPRC 动物护理计划和研究计划的发展。拟议的改进将加强恒河猴的繁殖操作，从而提高猴群的繁殖产量。这反过来又将确保向美国国立卫生研究院资助的研究人员和机构提供更多具有明确病毒学和遗传状态的印度恒河猴。