Novel Characterization and Detection Techniques for Acute Myocardial Ischemia

急性心肌缺血的新特征和检测技术

• 批准号: 10249962
• 负责人: Brian Zenger
• 金额: $ 3.4万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249962
• 关键词: 3-Dimensional; Accident and Emergency department; Acute; Animal Model; Body Surface; Cardiac; Cardiomyopathies; Chest Pain; Clinical; Clinical Research; Computer Models; Computer Simulation; Coronary; Coronary Arteriosclerosis; Coronary artery; Data; Data Set; Detection; Development; Diagnostic; Dissection; Dobutamine; Electrocardiogram; Emergency department visit; Ensure; Environment; Evaluation; Exercise; Experimental Animal Model; Experimental Models; Exposure to; Formulation; Goals; Heart; Heart Diseases; Hospital Departments; Image; Imaging Techniques; Infusion procedures; Ischemia; Lead; Location; Measurement; Measures; Mentors; Methods; Microvascular Dysfunction; Monitor; Myocardial; Myocardial Ischemia; Myocardial perfusion; Myocardial tissue; Myocardium; Non-Invasive Cancer Detection; Painless; Patients; Performance; Pharmacology; Physicians; Preparation; Procedures; Research; Resolution; Risk; Scientist; Sensitivity and Specificity; Source; Stress; Stress Tests; Stress cardiomyopathy; Surface; Techniques; Testing; Therapeutic; Tissues; Translating; Ultrasonography; Vascular blood supply; Visit; base; bioelectricity; clinical Diagnosis; common symptom; detection method; detection platform; electrical potential; experience; experimental study; imaging approach; improved; ischemic cardiomyopathy; models and simulation; novel; response; success

2 Abstract The most common reason for a patient to visit the emergency department is chest pain caused by myocar- dial ischemia. Myocardial ischemia develops from inadequate perfusion of myocardial tissue and indicates the presence of surprising range of conditions, including coronary artery disease, coronary microvascular dysfunc- tion, Takotsubo cardiomyopathy, and coronary artery dissection, and other potentially fatal cardiac diseases. Current noninvasive tests to detect ischemia may be limited by an incomplete understanding of the mecha- nisms used to induce the stress (exercise or pharmacological agents) or the limited diagnostic data acquired to visualize ischemia (12-lead electrocardiogram or ultrasound). These limitations increase the risk for failed detection of deadly cardiac diseases and explain the unsatisfactory accuracy of current diagnostic and monitor- ing approaches. The goal of this project is to leverage recent experimental findings and breakthroughs about the onset and progression of ischemia as the basis for a comprehensive re-evaluation of acute myocardial is- chemia. We will develop and use experimental models and computer simulations to devise better techniques to detect acute myocardial ischemia and localize it within the ventricles. We will build on our experience with our novel large-animal experimental models of ischemia and electrocardiographic imaging (ECGI) techniques to measure and characterize the electrical changes that arise during acute myocardial ischemia created from various types of ischemic stress. We will use these measurements to characterize different types of cardiac stress and implement novel ECGI techniques to detect and localize ischemic sources within the heart.

2 摘要 患者就诊急诊室的最常见原因是心肌梗死引起的胸痛。 心肌缺血是由于心肌组织灌注不足而发生的。 存在一系列令人惊讶的疾病，包括冠状动脉疾病、冠状动脉微血管功能障碍 病、Takotsubo 心肌病、冠状动脉夹层以及其他潜在致命的心脏病。 目前检测缺血的非侵入性测试可能会因对机制的不完全理解而受到限制。 用于诱发压力的精神（运动或药物）或获得的有限诊断数据 可视化缺血（12 导联心电图或超声）这些限制增加了失败的风险。 检测致命的心脏病并解释当前诊断和监测的准确性不令人满意的原因 该项目的目标是利用最近的实验发现和突破。 缺血的发生和进展作为全面重新评估急性心肌缺血的基础 我们将开发并使用实验模型和计算机模拟来设计更好的技术。 我们将利用我们的经验来检测急性心肌缺血并将其定位在心室内。 我们新颖的缺血大动物实验模型和心电图成像 (ECGI) 技术 测量和表征急性心肌缺血期间产生的电变化 我们将使用这些测量来表征不同类型的心脏缺血。 压力并实施新颖的 ECGI 技术来检测和定位心脏内的缺血源。