Animal Modeling Core

动物建模核心

• 批准号: 10249344
• 负责人: Richard A. Flavell
• 金额: $ 27.38万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10249344
• 关键词: Animal Model; Basic Science; Benign; Biological Assay; Blood Circulation; Blood Platelets; Cells; Communities; Disease; Educational process of instructing; Erythrocytes; Goals; Hematological Disease; Hematology; Hematopoiesis; Hematopoietic stem cells; Human; Immune system; Immunobiology; Immunodeficient Mouse; Mission; Modeling; Mus; Myeloid Cells; Population; Research; Research Personnel; Resources; Scientist; Stem cell transplant; Study models; Technical Expertise; Technology; Tissues; Training; Xenograft procedure; hematopoietic cell transplantation; humanized mouse; in vivo; innovation; mid-career faculty; mouse model; novel; professor; translational study

PROJECT SUMMARY/ The mission of the Animal Modeling Core (AMC) is to provide research groups within the YCCEH and the larger scientific community access to the latest technologies for hematologic studies in animal models. In vivo studies allow researchers to ask questions about the function of molecules, cell populations, and tissues within the relevant spatial and temporal contexts. The YCCEH will continue to provide scientists training and facilitate research in mouse models of hematologic diseases. Importantly, the AMC will continue to develop and propagate the most innovative humanized mouse models for the study of human hematopoiesis and diseases thereof with the goal to overcome major shortcomings of current models. The AMC consists of two cores, the Humanized Mouse Core (HMC) and the Murine Stem Cell Transplantation Core (mSCTC). The Animal Modeling Core will be directed by Dr Richard Flavell, Sterling Professor of Immunobiology and co-directed by Dr. Stephanie Halene, Associate Professor and Acting Section Chief of Hematology. The HMC will offer expertise, technical assistance, and mice for human-into-mouse xenotransplantation studies. The mSCTC will offer training and technical assistance in the study of hematopoiesis and benign hematologic questions in mice. The Humanized Mouse Core will facilitate human-into-mouse xenotransplantation studies into immunodeficient mice. As a unique feature the Yale HMC will offer hematology researchers access to novel humanized immunodeficient mice optimized to support human hematopoietic stem cells, trilineage hematopoiesis, mature myeloid cells, red cells and platelets in circulation, and a functional human immune system. The Murine Stem Cell Transplantation Core will provide technical expertise in the study of hematologic questions in mice. The mSCTC will offer training and expertise for the study of hematopoiesis and hematologic diseases in mice using hematopoietic cell transplantation and functional assays. The Animal Modeling Core will be an integral part of the YCCEH. It will provide Hematology researchers with access to state-of-the-art technologies for in vivo studies of hematopoiesis and hematologic diseases. It will provide teaching, expertise, and resources in an economical way. Its cores will support basic science as well as translational studies, key to understanding and cure of hematologic diseases.

项目摘要/ 动物建模核心（AMC）的使命是在YCCEH内提供研究小组 科学界访问动物模型中血液学研究的最新技术。体内研究 允许研究人员询问有关分子，细胞种群和组织功能的问题 相关的空间和时间环境。 YCCEH将继续为科学家提供培训并促进 血液学疾病小鼠模型的研究。重要的是，AMC将继续发展和传播 人类造血及其疾病的研究最具人性化的小鼠模型 克服当前模型的主要缺点的目标。 AMC由两个内核组成 小鼠核（HMC）和鼠干细胞移植核（MSCTC）。动物建模核心将 由斯特林免疫生物学教授理查德·弗拉维尔（Richard Flavell）博士指导，由斯蒂芬妮·哈琳（Stephanie Halene）博士共同执导 血液学副教授兼代理科负责人。 HMC将提供专业知识，技术援助， 和人类鼠标异种移植研究的小鼠。 MSCTC将提供培训和技术 在研究小鼠造血和良性血液学问题的研究中的帮助。人源化的小鼠 核心将促进对免疫缺陷小鼠的人类群异种移植研究。作为独特的功能 耶鲁大学HMC将为血液学研究人员提供优化的新型人性化免疫缺陷小鼠的机会 支持人造血干细胞，三利甲基菌素，成熟的髓样细胞，红细胞和血小板 在流通和功能性的人免疫系统中。鼠干细胞移植核心将提供 研究小鼠血液学问题的技术专长。 MSCTC将提供培训和专业知识 用于研究造血细胞移植和小鼠中造血和血液学疾病的研究 功能测定。动物建模核心将是YCCEH的组成部分。它将提供血液学 具有访问造血和血液学体内研究的最先进技术的研究人员 疾病。它将以经济的方式提供教学，专业知识和资源。它的核心将支持基本 科学以及转化研究，是了解和治愈血液学疾病的关键。