Autophagy, Inflammation and Metabolism (AIM) in Disease Center

疾病中心的自噬、炎症和代谢 (AIM)

• 批准号: 10249116
• 负责人: VOJO P DERETIC
• 金额: $ 218.04万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249116
• 关键词: Affect; Aging; Alzheimer' s Disease; Area; Autoimmune; Autoimmune Diseases; Autophagocytosis; Autophagosome; Award; Cardiovascular system; Cells; Center for Translational Science Activities; Centers of Research Excellence; Clinical Sciences; Communities; Complement; Core Facility; Cytoplasm; Dangerousness; Development; Development Plans; Diabetes Mellitus; Discipline; Disease; Equipment; Faculty; Funding; Future; Future Teacher; Goals; Grant; Growth; Growth Factor; Health; Health Sciences; Heart Diseases; Home; Human; Individual; Infection; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Infrastructure; International; Knowledge; Laboratories; Leadership; Lipids; Malignant Neoplasms; Maps; Medical; Mentors; Metabolic; Metabolism; National Institute of General Medical Sciences; Nerve Degeneration; Neurodegenerative Disorders; New Mexico; Obesity; Operations Research; Organelles; Pathway interactions; Physiological Processes; Plant Roots; Poaceae; Positioning Attribute; Process; Research; Research Personnel; Research Support; Resource Development; Resource Sharing; Resources; Secure; Solid; Starvation; Technical Expertise; Training; Translational Research; United States National Institutes of Health; Universities; Withdrawal; age related; base; bench to bedside; career; career development; cohort; faculty mentor; fighting; innovation; interest; novel; novel strategies; operation; patient population; programs; promoter; protein aggregation; recruit; symposium

SUMMARY Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health and disease with disorders ranging from inflammatory, metabolic (diabetes, obesity), infection, autoimmune, cancer, neurodegeneration, and aging. The proposed Center of Biomedical Research Excellence (CoBRE) for Autophagy, Inflammation, and Metabolism (AIM) in Disease will serve biomedical excellence for mentored research on autophagy and its interactions with inflammatory and metabolic processes. Both New Mexico and the nation lack a program to develop faculty and coherent research programs in this novel, evolving area with translational implications. With regional and national implications, AIM will close that gap. University of New Mexico Health Sciences Center (UNM HSC) employs national and international leaders in autophagy plus junior investigators exploring the intersections of inflammation, metabolism, and other processes with autophagy. UNM HSC offers (i) institutional support, (ii) future faculty hires, (iii) translational resources (Clinical and Translational Science Center), (iv) faculty mentoring, and (v) effective infrastructure to secure AIM as a national center of excellence. In turn, AIM will provide state-of-the-art equipment, technical expertise, training, and mentoring to win R01 funding for multiple new projects. AIM will build on the strength of the initial cohort of investigators and mentors, recruit new investigators, and develop a sustainable center to meet Institutional Development Award (IDeA) program goals. Specific Aim 1. Establish a nationally recognized AIM CoBRE to pioneer the study of autophagy and its connections with inflammation and metabolism as a basis of disease. Specific Aim 2. Develop a critical mass of investigators within AIM's research scope, establish mentoring infrastructure to enable junior faculty career development, and provide mentoring support for investigators to achieve independent NIH funding. Specific Aim 3. Establish scientific cores to enable present and future cohorts of mentored PIs, as well as the scientific community at UNM HSC and New Mexico. AIM will enable local growth in scientific resources, complement existing facilities without overlaps, develop a cadre of excellent faculty, and increase research funding institutionally and statewide. AIM will interface with other New Mexico IDeA centers and synergize without duplicating existing cores, facilities, and shared resources at UNM HSC and the region.

概括 自噬是所有健康人的基本稳态和代谢内过程 细胞。自噬在饥饿或生长因子戒断期间持续细胞代谢需求，清洁 通过去除受损细胞器和有毒蛋白质聚集体的细胞内部，并摆脱内源性或 炎症的外源启动子。越来越多地研究，自噬广泛影响人类健康， 疾病，疾病范围从炎症，代谢（糖尿病，肥胖），感染，自身免疫性， 癌症，神经变性和衰老。拟议的生物医学研究卓越中心（COBRE） 疾病的自噬，炎症和新陈代谢（AIM）将为指导而言为生物医学卓越服务 关于自噬及其与炎症和代谢过程相互作用的研究。新墨西哥州和 国家缺乏在这部小说中发展的教师和连贯研究计划的计划 翻译含义。有了区域和国家的影响，AIM将缩小这一差距。 新墨西哥大学健康科学中心（UNM HSC）雇用国家和国际领导人 在自噬和初级研究人员中，探索炎症，代谢和其他的交集 自噬的过程。 UNM HSC提供（i）机构支持，（ii）未来的教师雇用，（iii）翻译 资源（临床和转化科学中心），（iv）教师指导，（v）有效的基础设施 确保作为国家卓越中心的目标。反过来，AIM将提供最先进的设备，技术 专业知识，培训和指导，以赢得多个新项目的R01资金。目标将基于 最初的调查人员和导师队列，招募新调查员，并开发一个可持续的中心 符合机构发展奖（想法）计划目标。 特定目的1。建立一个全国认可的目标鞋垫，以开拓自噬及其其研究 与炎症和新陈代谢的联系作为疾病的基础。 具体目的2。在AIM的研究范围内开发大量的研究人员，建立指导 基础设施以实现初级教师职业发展，并为调查人员提供指导支持 获得独立的NIH资金。 特定目的3。建立科学核心，以实现当前和未来的指导PI，以及 UNM HSC和新墨西哥州的科学界。 AIM将使科学资源的当地增长，补充现有设施而没有重叠，发展 优秀教师的干部，并在制度和全州增加研究资金。 AIM将与 其他新墨西哥州的想法中心和协同作用，而无需重复现有的核心，设施和共享 UNM HSC和该地区的资源。