Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

基本信息

批准号：
10248819
负责人：
PETER M MOURANI
金额：
$ 7.24万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-13 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10248819
关键词：
Acute Acute Lung Injury Acute Renal Failure with Renal Papillary Necrosis Address Admission activity Area Arkansas Award Basic Science Blood Vessels Cardiopulmonary Cardiovascular Diseases Caring Catchment Area Child Child Development Child Health Childhood Childhood Injury Clinical Clinical Research Clinical Sciences Clinical Trials Clinical and Translational Science Awards Colorado Complement Activation Contracts Critical Care Critical Illness Critically ill children Data Data Coordinating Center Development Discipline Disease Enrollment Ensure Evaluation Faculty Family Functional disorder Funding Geography Goals Good Clinical Practice Immune response Institutes Institution Investigation Knowledge Laboratories Leadership Link Location Longitudinal Studies Lower Respiratory Tract Infection Lung Lung diseases Medicine Mentors Metadata Mission Mississippi Molecular Multiple Organ Failure National Heart, Lung, and Blood Institute Organ Outcome Outpatients Participant Pathogenesis Patients Pediatric Acute Lung Injury Pediatric Acute Respiratory Distress Syndrome Pediatric Hospitals Performance Physicians Population Population Heterogeneity Principal Investigator Procedures Process Program Development Protocols documentation Publications Recording of previous events Rehabilitation therapy Research Research Design Research Institute Research Personnel Research Priority Research Training Resources Respiratory Failure Role Rural SECTM1 gene Scientist Sepsis Series Site Talents Therapeutic Training Training Programs Translational Research Translations Traumatic Brain Injury United States National Institutes of Health Universities Vascular Diseases Work alveolar epithelium carbohydrate metabolism career development clinical research site cohort effective therapy expectation experience follow-up immunoregulation improved outcome innovation medically underserved meetings member multidisciplinary next generation outreach program participant enrollment pathogen patient population pediatric department programs racial and ethnic respiratory microbiome severe injury socioeconomics success translational clinical trial underserved community

项目摘要

ABSTRACT – University of Colorado Denver With our participation in this iteration of the Collaborative Pediatric Critical Care Research Network (CPCCRN), we contributed to a series of discoveries that enhanced our understanding of disease processes and resulted in a multitude of potentially effective treatments for critically ill and injured children that require definitive evaluation in clinical trials. There continues to be tremendous need for a collaborative research network in pediatric critical care to facilitate the swift and effective translation of scientific and technologic discoveries into clinical advances. Access to appropriate patients and expertise in the execution of clinical trials must be linked to scientists and laboratories working within and across disciplines at the cutting edge of scientific advancement. At the University of Colorado Denver (UCD) and Children’s Hospital Colorado (CHCO), we have a long history of successful collaborative basic, translational, and clinical science programs focused on pediatric critical illness and injury. We will provide several unique areas of strength to the CPCCRN, including: 1) a distinctive multidisciplinary team of collaborative researchers with specific expertise in mechanistic investigations of cardiovascular and pulmonary diseases, 2) a proven and successful track record as a clinical site in CPCCRN, 3) expertise with pediatric clinical trials execution, including innovative programs to enhance positive research culture among clinical staff and participation among patients and families, 4) a 7-state catchment area with high volumes of critically ill and injured children, 5) an in-house rehabilitation program and extensive outpatient outreach program capable of providing follow-up care to nearly all our critically ill patients, and 6) a dynamic partnership with the Children’s Hospital Colorado Research Institute and Colorado Clinical Translational Science Institute to provide extensive research resources. Our ancillary site, Arkansas Children’s Hospital (ACH) provides 1) experience with pediatric clinical trials execution, including previous successful membership in CPCCRN 2) provision of care to nearly all of the critically ill children from the State of Arkansas and a 4-state catchment area, 3) representation of an Institutional Development Award (IDeA) state (historically received low levels of NIH support) and involving their unique populations (rural, Marshallese, and medically underserved communities) in the NIH mission, and 4) a rich partnership with the ACH Research Institute and University of Arkansas Clinical Translational Science Award to provide comprehensive research resources. Utilizing these assets, we will augment the contributions of CPCCRN to the care of critically ill children through rigorous clinical trial execution, innovative translational and clinical trial proposals, participation in CPCCRN leadership committees, and training the next generation of pediatric critical care researchers. The proposed trial of “Personalized Immunomodulation in Sepsis induced Multiple Organ Dysfunction Syndrome” is an incredibly innovative approach that moves beyond a “one therapy for all” paradigm to an individualized therapeutic approach that will dramatically improve outcomes for children with sepsis. We are enthusiastic and committed to participate in this project with the new 24-site CPCCRN.

摘要 - 科罗拉多大学丹佛分校我们参与了协作小儿重症监护研究网络（CPCCRN）的这种迭代，我们为一系列发现做出了贡献，这些发现增强了我们对疾病过程的理解，并导致了需要确定评估的重症儿童和受伤儿童的多种潜在有效治疗在临床试验中。在小儿批判性的协作研究网络中仍然非常需要注意将科学和技术发现迅速有效地转化为临床进展。获得适当的患者和执行临床试验的专业知识必须与科学家有关在科学进步的最前沿内部和跨学科工作的实验室。在大学科罗拉多州丹佛（UCD）和科罗拉多州儿童医院（CHCO）的雕像，我们有悠久的成功历史协作基础，翻译和临床科学计划的重点是小儿重症疾病和伤害。我们将为CPCCRN提供几个独特的优势领域，包括：1）独特的多学科团队在心血管和肺部疾病，2）在CPCCRN中作为临床部位的经过验证的成功记录，3）专业知识小儿临床试验执行，包括增强积极研究文化的创新计划患者和家庭之间的临床人员和参与，4）一个7状态的集水区重病和受伤的孩子，5）内部康复计划和广泛的门诊外展计划能够为几乎所有重症患者提供后续护理，6）与儿童医院科罗拉多州研究所和科罗拉多州临床转化科学研究所提供广泛的研究资源。我们的辅助网站，阿肯色州儿童医院（ACH）提供1）经验通过小儿临床试验执行，包括以前成功的CPCCRN会员资格2）提供护理几乎所有来自阿肯色州和四州集水区的重症儿童机构发展奖（IDEA）国家（历史上获得低水平的NIH支持），并涉及他们在NIH任务中的独特人口（农村，马歇尔和医学服务不足的社区），以及 4）与ACH研究所和阿肯色大学临床转化科学的丰富合作伙伴关系奖励提供全面的研究资源。利用这些资产，我们将增加捐款 CPCCRN通过严格的临床试验执行，创新的翻译来照顾重症儿童以及临床试验建议，参加CPCCRN领导委员会以及培训下一代小儿重症监护研究人员。拟议的“败血症中个性化免疫调节的试验多器官功能障碍综合征”是一种令人难以置信的创新方法，它超越了“一种疗法对于所有的“范式”范式，将大大改善儿童的预后与败血症。我们很热情，并致力于与新的24个站点CPCCRN一起参加该项目。