Intervening to improve HIV treatment and reduce drinking in young, black men who have sex with men

进行干预以改善艾滋病毒治疗并减少男男性接触者的年轻黑人饮酒

• 批准号: 10247803
• 负责人: Justin Knox
• 金额: $ 17.75万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10247803
• 关键词: AIDS/HIV problem; Address; Adherence; Adoption; Age; Alcohol consumption; Alcohols; Behavior Therapy; Caring; Cellular Phone; Clinic; Continuity of Patient Care; Data; Development; Development Plans; Drug usage; Educational workshop; Epidemic; Evaluation; Focus Groups; Goals; HIV; HIV Infections; HIV Seropositivity; Health; Heavy Drinking; Incidence; Intervention; Intervention Studies; Interview; Knowledge; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Morbidity - disease rate; Motivation; NIH Office of AIDS Research; New York City; Outcome; Participant; Pharmaceutical Preparations; Process; Provider; Public Health; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Risk; Social Network; Social support; Technology; Testing; Time; Training; Treatment outcome; Underserved Population; Viral; Vulnerable Populations; Work; World Health Organization; base; black men who have sex with men; brief intervention; career development; checkup examination; disparity reduction; drinking; effective intervention; effectiveness implementation study; effectiveness implementation trial; efficacious intervention; efficacy evaluation; evidence base; follow-up; implementation intervention; implementation science; improved; informant; innovation; mHealth; member; men; mobile computing; mortality; motivational enhancement therapy; multidisciplinary; pilot trial; primary outcome; programs; racial minority; recruit; reduced alcohol use; retention rate; satisfaction; secondary analysis; sexual minority; skills; support network; symposium; theories; therapy development; training project; transmission process; AIDS/HIV problem; Address; Adherence; Adoption; Age; Alcohol consumption; Alcohols; Behavior Therapy; Caring; Cellular Phone; Clinic; Continuity of Patient Care; Data; Development; Development Plans; Drug usage; Educational workshop; Epidemic; Evaluation; Focus Groups; Goals; HIV; HIV Infections; HIV Seropositivity; Health; Heavy Drinking; Incidence; Intervention; Intervention Studies; Interview; Knowledge; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Morbidity - disease rate; Motivation; NIH Office of AIDS Research; New York City; Outcome; Participant; Pharmaceutical Preparations; Process; Provider; Public Health; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Risk; Social Network; Social support; Technology; Testing; Time; Training; Treatment outcome; Underserved Population; Viral; Vulnerable Populations; Work; World Health Organization; base; black men who have sex with men; brief intervention; career development; checkup examination; disparity reduction; drinking; effective intervention; effectiveness implementation study; effectiveness implementation trial; efficacious intervention; efficacy evaluation; evidence base; follow-up; implementation intervention; implementation science; improved; informant; innovation; mHealth; member; men; mobile computing; mortality; motivational enhancement therapy; multidisciplinary; pilot trial; primary outcome; programs; racial minority; recruit; reduced alcohol use; retention rate; satisfaction; secondary analysis; sexual minority; skills; support network; symposium; theories; therapy development; training project; transmission process

Significance. In the US, young, black men who have sex with men (YBMSM) are disparately impacted by HIV. For many YBMSM, heavy drinking or problems related to alcohol use adversely impacts their HIV care and treatment. Thus, interventions to improve HIV treatment outcomes and reduce heavy drinking in HIV-infected YBMSM in HIV treatment are urgently needed. Career Development Plan. Dr. Knox's training will include developing critical skills in intervention research and implementation science, and substantive training in HIV care and treatment. This will be achieved through a plan that includes seminars, workshops, coursework, conferences, and tailored mentoring. These activities will help Dr. Knox become an independent investigator with a research program focused on understanding and addressing HIV and alcohol use in vulnerable populations. Research Plan. In Aim 1, Dr. Knox's proposed research involves conducting formative work to inform the development of an intervention that addresses HIV treatment and alcohol use in heavy-drinking, HIV- infected, YBMSM. The intervention will borrow components from two distinct and potentially complementary, evidence-based clinic-based interventions that are brief and theory-driven. The first improves HIV treatment outcomes in HIV-infected YBMSM by involving a member of their social network to support them in HIV care. The second intervention addresses alcohol use by using smartphone technology to engage participants daily in self-monitoring relative to drinking reduction goals formed during a brief, motivational component of the baseline intervention session. In Aim 2, the information from this formative work will be synthesized with the help of consultant workgroups made up of YBMSM and implementation partners. The product of Aims 1 and 2 will be an innovative intervention that leverages both social network support and technology to improve HIV treatment outcomes and reduce alcohol use in heavy-drinking, HIV-infected YBMSM. It will be administered as a single- session baseline intervention with brief follow-up check-ins. In Aim 3, the new intervention will be pilot tested to assess its potential efficacy, acceptability, feasibility and implementation against a randomly assigned control condition among 60 heavy-drinking, HIV-infected YBMSM in an HIV clinic in New York City (NYC). As an epicenter of the HIV epidemic, interventions for young, black MSM in HIV treatment are urgently needed in NYC. The results of this pilot test will inform the development of an R01 proposal for a fully powered randomized controlled trial to evaluate the efficacy and implementation of the developed intervention. Mentorship. A team of expert investigators in alcohol and drug use, HIV, racial and sexual minorities, intervention development, implementation science and mixed methods will support this research. Public Health Impact. The project aims to reduce disparities in HIV treatment outcomes and, in turn, incidence of new HIV infections, a high research priority of the NIH Office of AIDS Research. Developing HIV interventions targeted for critical, underserved populations also works towards achieving important End the HIV Epidemic milestones.

意义。在美国，与男人发生性关系的年轻黑人（YBMSM）受到艾滋病毒的不同影响。 对于许多YBMSM，大量饮酒或与酒精使用有关的问题会对他们的艾滋病毒护理产生不利影响 治疗。因此，改善HIV治疗结果并减少艾滋病毒感染的大量饮酒的干预措施 迫切需要在HIV治疗中进行YBMSM。职业发展计划。诺克斯博士的培训将包括 在干预研究和实施科学方面发展关键技能，以及艾滋病毒的实质培训 护理和治疗。这将通过包括研讨会，研讨会，课程工作， 会议和量身定制的指导。这些活动将帮助诺克斯博士成为独立的研究者 研究计划的重点是理解和解决脆弱的艾滋病毒和饮酒 人群。研究计划。在AIM 1中，诺克斯博士提出的研究涉及进行形成性工作 告知开发一种处理艾滋病毒治疗和饮酒的干预措施， 感染，YBMSM。干预措施将从两个不同的且潜在的补充， 基于循证诊所的干预措施是简短且理论驱动的。第一个改善艾滋病毒治疗 通过参与其社交网络的成员来支持他们的艾滋病毒护理，YBMSM的结果是YBMSM的。 第二种干预措施通过使用智能手机技术每天吸引参与者来解决酒精的使用 相对于基线的简短激励组成部分形成的减少饮酒目标的自我监控 干预会议。在AIM 2中，这项形成性工作的信息将借助 顾问工作组由YBMSM和实施合作伙伴组成。目标1和2的产物将是 一种创新的干预措施，利用社交网络支持和技术来改善艾滋病毒治疗 结果并减少饮酒中的饮酒，在受HIV感染的YBMSM中。它将作为单个 会话基线干预，并进行简短的后续检查。在AIM 3中，将对新干预进行试点测试 评估其潜在的功效，可接受性，可行性和实施，以随机分配的控制 在纽约市的HIV诊所（NYC）的60种重饮HIV感染的YBMSM的病情中。作为 HIV流行病的中心，纽约市急需对HIV治疗的年轻，黑色MSM进行干预措施。 该试点测试的结果将为R01提案的开发提供信息 对照试验评估开发干预的功效和实施。指导。一个团队 饮酒和吸毒，艾滋病毒，种族和性少数群体的专家研究人员，干预发展， 实施科学和混合方法将支持这项研究。公共卫生影响。该项目的目标 为了减少艾滋病毒治疗结果的差异，进而减少新艾滋病毒感染的发病率很高 NIH艾滋病研究办公室的优先级。制定针对关键，服务不足的针对性的HIV干预措施 人口还致力于实现重要的艾滋病毒流行里程碑。