Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study Cohort

环境对北部平原安全通道研究队列儿童健康结果的影响

• 批准号: 10238845
• 负责人: Amy J Elliott
• 金额: $ 415.9万
• 依托单位: AVERA MCKENNAN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238845
• 关键词: Age; Alaska Native; Alcohols; Allergens; Allergic; American Indians; Area; Asthma; Attention; Behavioral; Breathing; Child; Child Health; Childhood; Cognitive; Cohort Studies; Complex; Consent; DNA Methylation; Data; Data Collection; Data Element; Data Set; Development; Electroencephalography; Elements; Emergency department visit; Ensure; Environmental Exposure; Exposure to; Family; Fetal Alcohol Exposure; Foundations; Future; Goals; Growth; Health; Hearing; Hospitalization; Individual; Infant; Infrastructure; Inhalant dose form; Intervention; Life; Measures; Mediating; Mediator of activation protein; National Institute of Child Health and Human Development; Neuraxis; Outcome; Participant; Pharmaceutical Preparations; Phase; Phenotype; Physiology; Population; Procedures; Protocols documentation; Recording of previous events; Research Personnel; Rest; Risk; Rural; School-Age Population; Sensory; Site; Sleep; Smoking; Stress; Sudden infant death syndrome; Symptoms; Testing; Tobacco; Training; Wheezing; Work; Youth; adverse outcome; airway inflammation; alcohol exposure; behavioral outcome; cohort; community engagement; dosage; early childhood; early life exposure; environmental stressor; executive function; feasibility testing; fetal; fungus; high risk population; indexing; infancy; innovation; neurodevelopment; neurodevelopmental effect; neurophysiology; non-Native; northern plains; patient engagement; postnatal; prenatal; prenatal exposure; pulmonary function; recruit; response; rural Americans; social; stillbirth; tobacco smoke exposure

Project Summary/Abstract The overarching premise of this proposal is that the extant and proposed cohorts (n>4400), infrastructure, and investigative team of PASS-ECHO are uniquely poised to answer questions relating to the impact of prenatal and early childhood environmental exposures on later health outcomes. To accomplish this objective, the study will build upon the successful study infrastructure established through the Prenatal Alcohol in SIDS and Stillbirth (PASS) Network (NICHD U02-HD045935) and will utilize this unique cohort to provide a wealth of prenatal and infant data that can expand the capability of the ECHO study in areas of neurodevelopment, neurophysiology, and asthma, particularly among rural and American Indian youth. The PASS-ECHO investigative team has a proven track record in conducting complex and high quality studies while maintaining longitudinal participant and community engagement in the region. Complementary to the common protocol, the PASS-ECHO cohort will examine in-depth data concurrent to individual-, family-, and social-level factors .While this proposal focuses on neurodevelopmental and asthma outcomes, the PASS-ECHO cohort is capable of including additional measures to provide additional data for the other ECHO focus areas. The PASS-ECHO investigators, infrastructure, and cohort have the capacity to contribute significantly to meet the overarching goal of ECHO.

项目摘要/摘要 该提案的总体前提是现存和拟议的同类（n> 4400），基础架构， 和Pass-echo的调查团队有独特的准备回答与有关影响的问题 产前和幼儿期环境暴露于后来的健康结果。为了实现这一目标， 这项研究将基于通过SIDS中的产前酒精建立的成功研究基础设施 和死产（PASS）网络（NICHD U02-HD045935），并将利用此独特的队列提供大量 可以在神经发育领域扩大回声研究能力的产前和婴儿数据， 神经生理学和哮喘，特别是在农村和美洲印第安人青年中。通行证 调查团队在进行复杂和高质量研究的同时，具有良好的记录 该地区的纵向参与者和社区参与。互补的公共协议， Pass-echo队列将检查与个体，家庭和社会水平因素的深入数据。 该提案侧重于神经发育和哮喘结果，Pass-Echo队列能够 包括其他措施，为其他回声焦点领域提供其他数据。通行证 调查人员，基础设施和队列有能力为达到总体而做出重大贡献 回声的目标。