Course and Outcome for Bipolar Disorder in Youth (COBY)

青少年双相情感障碍 (COBY) 的病程和结果

基本信息

批准号：
7661549
负责人：
MARTIN B KELLER
金额：
$ 51.57万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-08-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7661549
关键词：
Acute Adolescence Adolescent Adult Adverse effects Age Age Distribution Age of Onset Antidepressive Agents Anxiety Disorders Arts Attention deficit hyperactivity disorder Back Bipolar Disorder Child Childhood Chronic Disease Clinical Clinical Research Cognitive Cognitive deficits Collaborations Conflict (Psychology)Data Deterioration Development Diagnosis Disease Dose Event Exposure to Family Feeling suicidal Figs - dietary Frequencies Goals Impairment Intake Knowledge Life Light Maintenance Manic Mediating Mediator of activation protein Methodology Mood Disorders Mood stabilizers Moods Morbidity - disease rate National Institute of Mental Health Outcome Pattern Performance Performance at work Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Principal Investigator Psychopathology Psychotherapy Psychotic Disorders Public Health Public Policy Recording of previous events Recovery Recurrence Research Personnel Risk Sampling Second Degree Relative Severities Severity of illness Site Specific qualifier value Stabilizing Agents Staging Study Section Substance abuse problem Suggestion Suicide Suicide attempt Symptoms Testing Time Uncertainty Universities Youth base childhood bipolar disorder clinical phenotype cognitive function cohort depression disease classification disorder subtype early onset emerging adult evidence base follow up assessment follow-up functional outcomes improved indexing instrument longitudinal course prepuberty proband programs prospective psychosocial psychosocial adjustment sex success suicidal behavior treatment effect trend

项目摘要

DESCRIPTION (provided by applicant): This competing continuation of the study "Course and Outcome of Bipolar Youth" (COBY) will extend the follow-up of the sample for 5 more years. COBY is collaboration by the University of Pittsburgh, Brown University, and UCLA to investigate the longitudinal course of pediatric bipolar disorder (BP). As of 10/1/2005, we achieved our recruitment goal of 430 youth (186 children and 244 adolescents) with BP spectrum disorders (I, II and Not Otherwise Specified--NOS) using state-of-the-art clinical and analytic methodologies. Preliminary analyses of COBY's data are showing that pediatric BP is a rapid fluctuating and chronic illness associated with high psychosocial morbidity. However, limited data exists on the phenomenology, treatment responsiveness, and how course is influenced by the developmental transitions from childhood to adolescence, and adulthood. The unprecedented scientific and public health implications of COBY will accrue from ongoing observational data on a large, clinically diverse cohort of rigorously diagnosed subjects, which will enable us to: (1) describe the naturalistic course of recovery and recurrence patterns, as well as rapid mood changes, subsyndromal symptoms, and well periods into early adulthood; (2) identify predictors of long-term course and outcome; (3) describe psychosocial outcomes from childhood to early young adulthood; (4) describe treatments received and their effects in mediating course patterns; and 5) to explore domains of cognitive functioning across development in children and adolescents with BP spectrum disorders. Beyond the acquisition of new knowledge about long-term temporal patterns of pediatric-onset BP, an intrinsic value of extending the study of our cohort for another 5 years is that we will determine whether, and how, clinical phenotypes, psychopathological course trajectories, cognitive development and other important outcome variables change as probands move across developmental stages from childhood to young adulthood. Continued follow-up of the COBY sample at 6-month intervals using adaptations of instruments from the successful adult Collaborative Depression Study (CDS), will make it possible to develop more comprehensive knowledge on the above-noted aims given its large size, ascertainment from multiple sites, demographic and clinical diversity, and inclusion of subjects across the broad range of disease severity.

描述（由申请人提供）：“双相情感障碍青少年的过程和结果”(COBY) 研究的这项竞争性延续研究将把样本的随访时间再延长 5 年。 COBY 是匹兹堡大学、布朗大学和加州大学洛杉矶分校合作研究儿童双相情感障碍 (BP) 的纵向病程。截至 2005 年 10 月 1 日，我们使用最先进的临床和分析技术，实现了招募 430 名患有血压谱系疾病（I、II 和未另行指定 - NOS）的青少年（186 名儿童和 244 名青少年）的目标方法论。 COBY 数据的初步分析表明，儿童血压是一种快速波动的慢性疾病，与高心理社会发病率相关。然而，关于现象学、治疗反应性以及从童年到青春期和成年的发育转变如何影响病程的数据有限。 COBY 前所未有的科学和公共卫生影响将从对大量临床多样化的严格诊断受试者的持续观察数据中产生，这将使我们能够：（1）描述恢复和复发模式的自然过程，以及快速恢复的过程。情绪变化、亚综合征症状以及进入成年早期的良好时期； (2) 确定长期病程和结果的预测因素； (3) 描述从儿童期到成年早期的心理社会结果； (4) 描述所接受的治疗及其在调解过程模式中的效果； 5) 探索患有血压谱系障碍的儿童和青少年在整个发展过程中的认知功能领域。除了获得有关儿科发病血压长期时间模式的新知识之外，将我们队列的研究再延长 5 年的内在价值在于，我们将确定临床表型、精神病理过程轨迹、认知能力是否以及如何变化。随着先证者从童年到成年早期的各个发展阶段，发育和其他重要的结果变量会发生变化。使用成功的成人协作抑郁研究 (CDS) 的工具改编的方法，以 6 个月的间隔对 COBY 样本进行持续随访，鉴于其规模较大，将有可能就上述目标发展更全面的知识。多个地点、人口统计和临床多样性以及涵盖广泛疾病严重程度的受试者。