DISEASE MODIFYING GENES IN SEVERE ASTHMA

严重哮喘的疾病修饰基因

• 批准号: 7718395
• 负责人: JOAN REIBMAN
• 金额: $ 0.47万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718395
• 关键词: Adult; Allergens; Allergic; Asthma; Clinic; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Gene-Modified; Genes; Genetic Polymorphism; Genetic Variation; Grant; IgE; Inflammatory; Injury; Institution; Lung; Measurement; Patients; Phenotype; Physiological; Plethysmography; Predisposition; Property; Research; Research Personnel; Resources; Source; Spirometry; Susceptibility Gene; Symptoms; Testing; United States National Institutes of Health; airway obstruction; atopy; cohort; response; Adult; Allergens; Allergic; Asthma; Clinic; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Gene-Modified; Genes; Genetic Polymorphism; Genetic Variation; Grant; IgE; Inflammatory; Injury; Institution; Lung; Measurement; Patients; Phenotype; Physiological; Plethysmography; Predisposition; Property; Research; Research Personnel; Resources; Source; Spirometry; Susceptibility Gene; Symptoms; Testing; United States National Institutes of Health; airway obstruction; atopy; cohort; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a heterogeneous disease in adults, with some expressing mild disease, whereas others have severe symptoms. Some adults with asthma progress to severe irreversible airway obstruction, whereas other maintain airway function. The investigators have identified a large cohort of patients with atopy and persistent airway obstruction in their urban clinic of adult patients with asthma. The question arises, therefore, whether in the atopic subject with asthma, there are disease modifying genes that predispose to the development of irreversible airway obstruction. The global aim of this proposal will be to test the hypothesis that in a susceptible host, there are disease-modifying genes that modulate the response to the repetitive allergic inflammatory injury. The focus will be to define precise physiologic phenotypes of severe asthma and to test the association between allelic variants in airway/matrix remodeling genes and the defined severe phenotypes. More specifically, the study's aims are as follows: 1) To identify specific physiologic phenotypes of "severe asthma" defined by spirometry, plethysmography and measurement of elastic recoil properties of the lung. 2.)To test the hypothesis that asthma susceptibility as determined by IgE (total and allergen-specific) discriminates the physiologic phenotypes of severe asthma. 3) To test the hypothesis that polymorphisms of matrix remodeling genes are associated with physiologic phenotypes of severe asthma (disease-modifying genes).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 哮喘是成年人的一种异质性疾病，有些表达轻度疾病，而另一些则具有严重的症状。一些患有哮喘的成年人会发展为严重的不可逆气道阻塞，而另一些则保持气道功能。 研究人员已经确定了大量的成年哮喘患者城市诊所中有特应性​​和持续气道阻塞的患者。因此，出现的问题是，在患有哮喘的特征性受试者中是否会改变疾病，使基因易不可逆的气道阻塞的发展。该提案的全球目的是检验以下假设：在易感宿主中，有一些疾病改良的基因调节对重复过敏性炎症性损伤的反应。重点是定义严重哮喘的精确生理表型，并测试气道/基质重塑基因中的等位基因变体与定义的严重表型之间的关联。 更具体地说，该研究的目的如下：1）确定由肺活量测定法，杂质学和测量肺弹性后坐力特性定义的“严重哮喘”的特定生理表型。 2.）检验以下假设：由IgE（总和特异性和过敏原）确定的哮喘易感性可以区分严重哮喘的生理表型。 3）检验以下假设，即基质重塑基因的多态性与严重哮喘（疾病调整基因）的生理表型有关。