Central Nervous System HIV Translational Research Training Program

中枢神经系统艾滋病毒转化研究培训计划

• 批准号: 8012332
• 负责人: RICHARD W. PRICE
• 金额: $ 13.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8012332
• 关键词: HIV; Neuraxis; Research Training; Training Programs; Translational Research

DESCRIPTION (provided by applicant): Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and central nervous system (CNS) opportunistic Infections continues to be limited, and indeed in the current era of combination antiretroviral therapy (cART), the manifestations and likely pathogenesis of HIV-1- and Immunosuppression- related neurological diseases continue to evolve. Thus, further dedicated investigation in the field of neuro- HIV, with a dynamic, multidisciplinary, and international perspective Is of major importance. The objective of this Training Program Is to provide a closely mentored program for physician scientists to develop careers in translational research relevant to the pathogenesis and treatment of HIV infection and associated opportunistic infections in the nervous system. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program supported by a program faculty of 19 established investigators in HIV/AIDS research at UCSF and four extramural members of an external advisory committee. Our multidisciplinary training program includes opportunities in immunology, virology, clinical trials, disease progression, acute HIV, public health, HIV and aging, neuroimaging, and international research. Our three-year training program offers opportunities for both laboratory-based experiences and hypothesis-driven clinical and epidemiologic investigation. Postdoctoral training will be offered to clinically trained scientists with M.D. degrees and prior specialty training. In addition to laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and a seminar series on the responsible conduct of research. Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and CTSI and CFAR supported grant-writing workshops and courses in the preparation of extra-mural funding applications, with the goal of obtaining independent career- development awards by the conclusion of the fellowship. The program is designed to train a small number (one new fellow per year) of physician-scientist candidates who are highly motivated to gain expertise in the specialized area of clinical and translational neuro-AIDS research. With abundant resources in the form of study participants, outstanding local collaborators, and educational opportunities, UCSF/SFGH provides an exemplary environment for training in neuro-AIDS, facilitating the establishment of solid and visionary research programs by early-career stage investigators. RELEVANCE: Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and CNS opportunistic infections continues to be limited, thus, further dedicated investigation in the field of neuro-HIV, with a dynamic, multidisciplinary, international and collaborative perspective, is of major importance. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program for training of future leaders in the field of neurological complications of HIV. The potential of further advancement in the understanding, treatment, and ideally protection against HIV-related neurological disorders is critical for the over 30 million people worldwide living with HIV infection.

描述（由申请人提供）：我们对 HIV-1 和中枢神经系统 (CNS) 机会性感染的神经发病机制的基本方面的了解仍然有限，事实上，在当前联合抗逆转录病毒疗法 (cART) 的时代，其表现和HIV-1 和免疫抑制相关神经系统疾病的可能发病机制仍在不断发展。因此，以动态、多学科和国际视角对神经艾滋病毒领域进行进一步专门研究至关重要。该培训计划的目的是为医师科学家提供密切指导的计划，以发展与艾滋病毒感染和神经系统相关机会性感染的发病机制和治疗相关的转化研究职业。 本申请寻求对 UCSF/SFGH CNS HIV 研究奖学金培训计划的支持，这是一项正式的临床和转化研究培训计划，由 UCSF 的 19 名 HIV/AIDS 研究人员和外部咨询委员会的 4 名校外成员组成的项目教员支持。我们的多学科培训计划包括免疫学、病毒学、临床试验、疾病进展、急性艾滋病毒、公共卫生、艾滋病毒和衰老、神经影像学和国际研究的机会。我们为期三年的培训计划为基于实验室的经验和假设驱动的临床和流行病学调查提供了机会。博士后培训将为拥有医学博士学位并接受过专业培训的临床科学家提供。除了实验室或临床研究之外，学员还将参加一系列定期安排的课程、研讨会、期刊俱乐部、会议以及关于负责任的研究行为的研讨会系列。通过精心挑选的教学和教育计划，并通过正式的指导流程密切监控学员的进度，学员将获得设计和执行严格的调查项目、分析数据并发布结果的技能。学员将在导师以及 CTSI 和 CFAR 支持的资助写作研讨会和课程的指导下准备校外资助申请，目标是在奖学金结束时获得独立的职业发展奖项。该计划旨在培训少数（每年一名新研究员）医师科学家候选人，他们非常积极地获得临床和转化神经艾滋病研究专业领域的专业知识。 UCSF/SFGH 拥有丰富的研究参与者资源、优秀的当地合作者和教育机会，为神经艾滋病培训提供了模范环境，促进早期职业阶段研究人员建立扎实且富有远见的研究项目。相关性：我们对 HIV-1 和 CNS 机会性感染的神经发病机制的基本方面的了解仍然有限，因此，以动态、多学科、国际和协作的视角对神经 HIV 领域进行进一步的专门研究具有重要意义。重要性。本申请寻求对 UCSF/SFGH CNS HIV 研究奖学金培训计划的支持，这是一个正式的临床和转化研究培训计划，用于培训 HIV 神经并发症领域的未来领导者。进一步推进对 HIV 相关神经系统疾病的理解、治疗和理想保护的潜力对于全球超过 3000 万 HIV 感染者至关重要。