Electronic cigarette use in lung cancer patients

肺癌患者使用电子烟

• 批准号: 10087897
• 负责人: Theodore M. Brasky
• 金额: $ 16.51万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087897
• 关键词: Address; Adherence; Adult; Advisory Committees; Advocate; Affect; Area; Behavioral Research; Benefits and Risks; Cancer Center; Cancer Patient; Chest; Cigarette; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Comprehensive Cancer Center; Counseling; Country; Data; Data Collection; Development; Devices; Electronic Nicotine Delivery Systems; Electronic cigarette; Environment; Epidemiologist; Excision; Fostering; Funding; Future; General Population; Goals; Guidelines; Health; Health Benefit; Health Promotion; Health behavior; Institution; Intervention; Intervention Studies; Investigation; Malignant Neoplasms; Malignant neoplasm of lung; Marketing; Measures; Mentors; Mentorship; Metabolism; National Comprehensive Cancer Network; National Institute of Drug Abuse; Observational Study; Ohio; Operative Surgical Procedures; Outcome; Patient Recruitments; Patients; Performance Status; Perioperative complication; Persons; Pilot Projects; Policies; Population; Positioning Attribute; Principal Investigator; Professional Organizations; Prospective cohort; Public Health; Quality of life; Randomized; Randomized Clinical Trials; Recommendation; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Safety; Sales; Science; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Standardization; Surgeon; Surgical complication; Symptoms; Tobacco; Tobacco use; Toxic effect; Training; Treatment-related toxicity; United States; United States Food and Drug Administration; Universities; authority; cancer epidemiology; cancer survival; career development; chemotherapy; cigarette smoking; cohort; college; combustible cigarette; design; editorial; electronic cigarette use; evidence base; experience; exposure to cigarette smoke; follow-up; hospital utilization; member; nicotine replacement; patient population; professor; randomized trial; skills; smoking cessation; sound; standard of care; symptomatology; tobacco control; tobacco regulatory science; tool; treatment as usual; treatment guidelines; uptake; week trial

PROJECT SUMMARY/ABSTRACT The overall goal of this proposal is to facilitate Dr. Theodore Brasky’s development into an established and independent investigator for tobacco control. For this research, he will focus on cancer patients and the impact of electronic cigarettes (e-cigs) on cigarette smoking, quitting, and health outcomes. It is established that cigarette smoking adversely affects the cancer patient in many ways. E-cigs have the potential to reduce cigarette smoke exposures, related toxicities, and foster smoking cessation. However, almost no research exists to substantiate this hypothesis. Dr. Brasky is a cancer epidemiologist and member of the Ohio State University Comprehensive Cancer Center (OSUCCC) with considerable expertise in the analysis and interpretation of longitudinal data. Due to a strong institutional environment, he has been participating in various tobacco-focused research projects over the past 2 years. Excited by this, he wants to take advantage of the extraordinary opportunities in tobacco control related to e-cigs. The proposed training plan will enable him to obtain expertise and experience in tobacco research (e.g., coursework in tobacco regulatory science), intervention studies (e.g., coursework in clinical research methods and translational behavioral research), and primary data collection in complementary studies. This training will capitalize on the exceptional institutional environment at OSU and a mentoring team of experts in tobacco control led by Dr. Peter Shields, Deputy Director of the OSUCCC, and Dr. Mary Ellen Wewers, Professor of Health Behavior and Health Promotion at the OSU College of Public Health. Dr. Shields and Dr. Wewers are Multiple Principal Investigators of OSU’s NCI-funded P50 Tobacco Center of Regulatory Science. Herein, Dr. Brasky will address critical research gaps that will aid in the understanding for the impact of e-cigs on the cancer patient generally, and specifically for the creation of sound policy decisions by the Food and Drug Administration. This application will address the smoking lung cancer patient who will be assessed for cigarette and e-cig use in relation to uptake, smoking reduction, quitting, quality of life, and treatment toxicities. The Specific Aims are: 1) to establish an observational cohort of 300 lung cancer patients and examine the associations of e-cigs with smoking reduction, smoking cessation, quality of life, and treatment toxicities; and 2) to establish a pilot randomized trial of a newly-developed research e-cig versus nicotine replacement therapy (standard of care) in 30 stage I-IIIA lung cancer patients planning to undergo surgical resection in order to foster adherence to recommendations and reduce surgical complications. This pilot study will leverage newly-implemented National Cancer Center Network guidelines for smoking cessation at the OSUCCC, and a new e-cig research device provided by the National Institute on Drug Abuse. These complementary experimental and ‘real world’ observational studies will be the first to examine associations in lung cancer patients and will share assessment measures. Results from this research will yield critical data in order to provide sound and evidence-based decisions on e-cigs.

项目概要/摘要 该提案的总体目标是促进 Theodore Brasky 博士发展成为一个成熟的、 在这项研究中，他将重点关注癌症患者及其影响。 电子烟（e-cigs）对吸烟、戒烟和健康结果的影响。 吸烟对癌症患者的影响有很多方面，电子烟有可能减少癌症患者的不良影响。 然而，几乎没有关于香烟烟雾暴露、相关毒性和促进戒烟的研究。 Brasky 博士是一位癌症流行病学家，也是俄亥俄州立大学的成员。 大学综合癌症中心 (OSUCCC) 在分析和治疗方面拥有丰富的专业知识 由于强大的制度环境，他一直参与纵向数据的解释。 过去两年中各种以烟草为重点的研究项目让他感到兴奋，他想利用这一点。 拟议的培训计划将使电子烟相关的烟草控制中的非凡机遇成为可能。 他获得烟草研究方面的专业知识和经验（例如烟草监管科学课程）， 干预研究（例如临床研究方法和转化行为研究的课程），以及 补充研究中的主要数据收集将利用特殊的机构。 俄勒冈州立大学的环境和由副教授 Peter Shields 博士领导的烟草控制专家指导团队 OSUCCC 主任和 Mary Ellen Wewers 博士，健康行为和健康促进教授 希尔兹博士和韦尔斯博士是俄勒冈州立大学公共卫生学院的多名首席研究员。 Brasky 博士将在 NCI 资助的 P50 烟草监管科学中心解决关键的研究空白。 这将有助于了解电子烟对癌症患者的总体影响，特别是对 该应用程序将解决食品和药物管理局制定合理的政策决定的问题。 吸烟的肺癌患者将接受香烟和电子烟使用与摄取、吸烟相关的评估 减少、戒烟、生活质量和治疗毒性的具体目标是： 1) 建立一个 300 名肺癌患者的观察队列并检查电子烟与吸烟的关联 减少吸烟、戒烟、生活质量和治疗毒性；2) 建立一项随机试验； 新开发的研究电子烟与尼古丁替代疗法（护理标准）在 30 个 I-IIIA 期患者中的比较 计划接受手术切除的肺癌患者以促进对建议的遵守 并减少手术并发症。这项试点研究将利用新成立的国家癌症中心。 OSUCCC 的戒烟网络指南以及由 OSUCCC 提供的新型电子烟研究设备 国家药物滥用研究所。这些互补的实验和“现实世界”观察研究。 将第一个检查肺癌患者的关联并分享评估结果。 这项研究将产生关键数据，以便为电子烟提供合理且基于证据的决策。