Assessing the commercial potential of high-density electrodes with single unit recording and stimulation capabilities.

评估具有单一单元记录和刺激功能的高密度电极的商业潜力。

• 批准号: 10087359
• 负责人: Ingrid van Welie
• 金额: $ 5.5万
• 依托单位: NEURAL DYNAMICS TECHNOLOGIES INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2021-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087359
• 关键词: Acute; Amplifiers; Animals; Behavior; Brain; Brain region; Chronic; Custom; Electrodes; Grant; Individual; Innovation Corps; Methods; Microelectrodes; Neurons; Neurosciences Research; Phase; Process; Production; Research Personnel; Rodent; Small Business Innovation Research Grant; System; Technology; United States National Institutes of Health; awake; commercialization; cost; density; design; experimental study; innovation; neural circuit; programs; relating to nervous system

SF424 – Project Summary Understanding how the brain generates certain behaviors requires an understanding of the function of individual neurons in dynamical neural circuits. Currently, there are few technologies available however that allow researchers to record both the activity within a brain region, and between brain regions in the brains of awake, behaving animals. Recent advances in microelectrode fabrication are now enabling recordings of recording hundreds to thousands of neurons simultaneously across brain regions that will lead to functional analyses of dynamical neural circuits. To date however, there are no commercially available low-cost solutions for these kinds of high-density probes. In addition, available high-density probes do not offer customization in design and layout. Neural Dynamics Technologies develops low-cost, highly customizable, high-density probes for acute and chronic experiments in rodents. These probes are innovative because they rely on a new fabrication process that allows for both customization in probe design and low-cost fabrication. Furthermore, our probes are compatible for integration with existing commercial amplifier systems that are standardly used for both acute and chronic experiments in rodents. The first aim of our SBIR proposal was to streamline the design process of high-density probes such that the fabrication process will be ready to produce a wide variety of probe designs at low cost. The second aim involves streamlining the production methods to enable fabrication of customizable probes with broad compatibility with existing commercial amplifier systems. Currently, the above-mentioned aims of our Phase I proposal are largely achieved, and to prepare for commercialization, we would like to participate in the NIH I-Corps program so that we can determine best product-customer fit for our technology.

SF424 - 项目摘要 了解大脑如何产生某些行为需要了解 单个神经元在动态神经元中的功能。目前，很少 但是，可用的技术使研究人员可以在 大脑区域以及醒着的大脑之间的大脑区域，行为动物。最近的 微电极制造的进步现在正在实现记录的记录 跨大脑区域的数百至成千上万的神经元将导致 动态神经回路的功能分析。但是到目前为止，没有 用于此类高密度问题的市售低成本解决方案。在 补充，可用的高密度问题不提供设计和布局的自定义。 神经动力技术发展低成本，高度可定制，高密度 啮齿动物中急性和慢性实验的探针。这些问题是创新的 因为他们依靠一个新的制造过程，该过程允许两者自定义以证明 设计和低成本制造。此外，我们的问题是集成的 使用现有的商业放大器系统，通常用于急性和 啮齿动物中的慢性实验。我们SBIR提议的第一个目的是简化 高密度问题的设计过程，使制造过程可以准备好 以低成本生产各种探针设计。第二个目标涉及精简 生产方法可以使可定制的问题与广泛的可定制问题制造 与现有商业放大器系统的兼容性。 目前，我们的第一阶段提案的上述目标已在很大程度上实现，并且 为了准备商业化，我们想参加NIH I-Corps计划 这样我们就可以确定最适合我们技术的产品。