Understanding the effects of substance use on male couples risk for HIV

了解物质使用对男性夫妇感染艾滋病毒风险的影响

• 批准号: 10372367
• 负责人: Jason W Mitchell
• 金额: $ 33.44万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372367
• 关键词: Understanding; effects; substance; use; male

 DESCRIPTION (provided by applicant): Despite between one- and two-thirds of US men who have sex with men (MSM) acquire HIV from their primary 4 same-sex relationship partner (i.e., male couples), most HIV prevention efforts have targeted MSM at the 5 individual- and community-levels. Substance use is also an important Public Health issue that affects HIV 6 acquisition and transmission among MSM; substances are often used to enhance pleasure and sustain 7 engagement in sexual behaviors including condomless anal sex (CAS). Findings from the few studies 8 conducted with male couples indicate their use of substances with sex negatively impacts their relationship 9 dynamics and behaviors related to HIV prevention, including CAS with casual MSM partners and poor 10 treatment adherence. Although these findings suggest the need to intervene for prevention, less is known 11 about how primary partners within the male couple influence one another's use of substances, the different 12 context(s) in which they use substances, and how their usage directly affects their risk for HIV and dynamics of 13 the relationship. To that calling, we propose to conduct a 4-year mixed method study that is theoretically 14 grounded to examine how male couples' use of substances affects their relationship and risk for acquisition 15 and/or transmission of HIV. We will use venue-time sampling to recruit 225 substance-using male couples, 16 diverse in terms of HIV status and relationship length, from community and Internet venues in South Florida. 17 We will collect qualitative and quantitative longitudinal dyadic data over a 6-month period to examine the 18 associations between intrapersonal, interpersonal and contextual factors in general and with event level 19 substance use. Participants will complete in-person ACASI at 3 time points (baseline, 3 and 6 months), and 20 daily ecological momentary assessments (EMA) during months 2 and 5. Every third reported substance use 21 event will be supplemented with an in-depth phone interview. All data will be collected independently from each 22 partner of the couple, and couples' substance use and HIV serostatus will be verified at baseline, 3 and 6 23 months. Longitudinal quantitative data obtained from the ACASI and EMA will be analyzed using 24 mixed/multilevel models, including actor-partner effects. Qualitative content analysis, specifically latent and 25 manifest content analysis, will be used to identify and describe the major themes and sub-themes that emerge 26 from the phone interview data. We will use standard mixed methodology to integrate the quantitative and 27 qualitative findings to elucidate how primary partners' influence one another's use of substances and risk for 28 HIV, and how their usage affects dynamics of their relationship. Under the direction of Mitchell, he and his 29 team of senior co-investigators will disseminate these findings, and apply them toward development of a 30 couples-focused HIV and substance use preventive intervention for use in a future project.

 描述（由申请人提供）：尽管有与男性发生性关系的美国人（MSM）在Prime-性关系伴侣（即男性夫妇）中获得HIV，但大多数HIB预防效果都针对5个个体的MSM和社区级别的使用也是公共健康。与艾滋病毒D有关的影响9 S和与艾滋病毒有关的行为，较少的是男性cale夫妇对彼此使用的物质的使用。对于13的艾滋病毒和动态，我们建议进行一项为期4年的方法，从理论上讲是14个，以研究男性夫妇的物质如何影响其收购和/或传播的风险HIV。在3个时间点（基线，3和6个月）和20个每日生态瞬时评估（在第2和5个月期间EMA），以检查，人际关系和环境之间的18个关联，人际关系和上下文之间的18个关联。从夫妇的每个22个合作伙伴中划分，并在基线时将夫妻使用的物质使用3和6 23个月。演员伴侣的效果。阐明主要合作伙伴的影响力是如何互相影响的，并且对28 HIV 28 HIV的风险以及使用方式如何影响Mitchell的方向，他和他的29个高级共同投资团队将呈现出来。 DEVELOPMENT OF A 30 Couples-Focusted Hiv and substance USE PREVENTINTINTINTINTINTINTINTINTINTINTINTINTINTINTINTINT someT some Use in a Future Project.