Diversity Supplement

多样性补充

• 批准号: 10085105
• 负责人: Margaret Gichane
• 金额: $ 14.13万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10085105
• 关键词: AIDS prevention; Adherence; Adolescence; Age; Attitude; Belief; Birth; Birth Weight; Birth length; Clinical; Communicable Diseases; Data; Development; Female Adolescents; Foundations; Funding; Future; Gestational Age; Guidelines; HIV; HIV Infections; HIV risk; Head circumference; Intervention; National Institute of Child Health and Human Development; Outcome; Population; Postpartum Period; Pregnancy; Pregnancy Outcome; Prevention strategy; Provider; Recommendation; Research; Research Personnel; Risk; South Africa; Spontaneous abortion; Strategic Planning; Training; United States National Institutes of Health; Woman; World Health Organization; aged; evidence base; experience; fetal; global health; healthy pregnancy; improved; pre-exposure prophylaxis; pregnant; pregnant teen; skills; unintended pregnancy; uptake; young adult; young woman

PROJECT SUMMARY/ABSTRACT Adolescence and young adulthood are periods of high vulnerability to HIV and unintended pregnancies for young women in South Africa. Adolescent girls and young women (AGYW) aged 15 to 24 comprise 25% of new HIV infections in South Africa. Additionally, 18% of AGYW give birth by age 18. HIV risk increases significantly during pregnancy and postpartum, highlighting the need for efficacious HIV prevention strategies for this population. The World Health Organization guidelines recommend that women continue using PrEP if they become pregnant and remain at risk for HIV. However, South Africa has not yet implemented these recommendations into its national PrEP guidelines. This 2-year diversity supplement seeks to build the evidence base on PrEP use among pregnant AGYW and aligns with NICHD's Strategic Plan, Setting the Foundation for Healthy Pregnancies and Lifelong Wellness under the cross-cutting topics of infectious disease and global health. The Specific Aims are: Aim 1: Compare pregnancy outcomes (e.g., termination, miscarriage) and birth outcomes (e.g., gestational age, birth weight, birth length, fetal head circumference) between pregnant AGYW who uptake PrEP and those who do not. Aim 2: Examine the association between pregnancy and PrEP adherence and persistence among AGYW. Aim 3: Use journey mapping to examine and depict pregnant AGYW's experience using PrEP. Aim 4: Qualitatively explore provider attitudes and beliefs toward AGYW who are pregnant and use PrEP and providers clinical recommendations regarding PrEP use during pregnancy. Throughout the supplement period, the proposed candidate will engage in a variety of research and professional development activities, including participating in didactic trainings, continuing to produce scholarly research, and applying for additional National Institute of Health (NIH) funding. The activities comprising this supplement will provide the candidate with opportunities to enhance the necessary skills to become an independent NIH-funded researcher. Preliminary study data will be applied to a future NIH R21 proposal to develop an intervention to improve PrEP adherence and persistence among pregnant and postpartum AGYW in South Africa.

项目摘要/摘要 青春期和年轻成年是艾滋病毒和意外怀孕的高脆弱时期 对于南非的年轻妇女。 15至24岁的青少年女孩和年轻女性（AGYW）占25％ 南非的新艾滋病毒感染。此外，AGYW的18％按18岁。艾滋病毒风险增加 在怀孕期间和产后，重要的是，强调需要有效预防艾滋病毒的策略 对于这个人群。世界卫生组织指南建议妇女继续使用PREP 他们怀孕并仍然有艾滋病毒的危险。但是，南非尚未实施这些 建议其国家准备指南。这种为期两年的多样性补充旨在建立 关于怀孕AGYW和NICHD的战略计划的准备的证据基础 在传染性的横切主题下，健康怀孕和终身健康基础 疾病和全球健康。 具体目的是： 目标1：比较怀孕结果（例如终止，流产）和出生结果（例如， 胎龄，出生体重，出生时间，胎儿头围） 谁吸收准备和那些没有的人。 目的2：检查怀孕与准备依从性与持久性之间的关联 Agyw。 AIM 3：使用旅程映射检查并描绘了使用Prep的Agyw的经验。 目标4：定性地探索提供者对怀孕和使用的AGYW的态度和信念 预备和提供者有关怀孕期间准备使用的临床建议。 在整个补充期间，拟议的候选人将从事各种研究， 专业发展活动，包括参加教学培训，继续生产 学术研究，并申请额外的国家卫生研究院（NIH）资金。活动 包括此补充剂将为候选人提供增强必要技能的机会 成为一名独立的NIH资助的研究员。 初步研究数据将应用于未来的NIH R21提案，以开发干预措施以改善 南非怀孕和产后AGYW的预科遵守和持久性。