Metal Organic Frameworks-Based Next-Generation Sunscreens for Cancer Prevention

基于金属有机框架的下一代癌症预防防晒霜

基本信息

  • 批准号:
    10082046
  • 负责人:
  • 金额:
    $ 38.46万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-12 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract In this grant application, framergy, in collaboration with Baylor College of Medicine, will demonstrate a promising next- generation skin cancer prevention technology, with the ultimate goal being successful commercialization and life-changing public benefit. The team will utilize a novel class of nanostructured material, called Metal-organic Frameworks (MOFs), to prevent ultraviolet (UV)-induced melanoma and squamous cell carcinomas by blocking UV light and absorbing cancer triggering, byproduct free-radicals on the skin. Studies have shown that exposure to solar radiation (UV/Visible radiation) from the sun results in sunburn and has been linked to premature skin aging, immunosuppression and skin cancer. The number of new cases of melanoma has been increasing for at least 30 years. Sunscreen may help decrease the amount of UV radiation to the skin. According to National Cancer Institute, wearing sunscreen can help prevent actinic keratoses, scaly patches of skin that sometimes- become squamous cell carcinoma. Despite increased use of sunscreens over the years, skin cancer rates have continued to rise. There are two impediments to the development of next generation sunscreens: 1) The insufficient magnitude of UV protection of current products on the market, including strong inorganic UV protectors like TiO2 and ZnO, and 2) the fact that these inorganic protectors generate reactive oxygen species (ROS) which combine with organic compounds in the formula, or on the skin, to form harmful byproducts. Recent advances in porous coordination network materials, such as MOFs, can address the need for improved breadth and magnitude of UV protection while capturing the toxic reactive oxygen species and radical byproducts generated under solar radiation. During Phase I, framergy will down-select the optimal titanium MOF for the composition through UV absorbance testing, heat of adsorption testing, water stability testing and controlled particle size synthesis. Further, framergy will take a top down and bottom up approach to demonstrate the performance of organic peroxide scavenging of the MOF. Baylor College of Medicine will assist this technology development activity by performing biological experiments in 2D cell models measuring the effects of UV irradiation on DNA damage and ROS production, with and without the application of MOFs. These assays will be imaging-based, medium and high throughput automated experiments coupled with single cell analytics. This will help shed light on the role of MOFs in the prevention of UV induced melanomas. Testing MOFs in 3D skin models across Phase I and II will further strengthen results ahead of preclinical studies. In the Phase II period, framergy and the BCM team will collaborate with Texas Institute for Preclinical Studies (Texas A&M University) to conduct preclinical trials to conduct cytotoxicity and photogenotoxicity studies to transition the product development activities from cell-level to large animal preclinical trials.
项目概要/摘要 在这项拨款申请中,framergy 与贝勒医学院合作,将展示一个有前途的下一步- 新一代皮肤癌预防技术,最终目标是成功商业化并改变生活 公共利益。该团队将利用一种新型纳米结构材料,称为金属有机框架(MOF), 通过阻挡紫外线和吸收癌症来预防紫外线 (UV) 诱发的黑色素瘤和鳞状细胞癌 触发皮肤上的副产物自由基。 研究表明,暴露于太阳辐射(紫外线/可见辐射)会导致晒伤,并且已被 与皮肤过早老化、免疫抑制和皮肤癌有关。黑色素瘤新病例数 增长至少30年。防晒霜可能有助于减少皮肤受到的紫外线辐射量。根据 美国国家癌症研究所称,涂抹防晒霜有助于预防光化性角化病,这是一种有时会导致皮肤鳞状斑块的疾病—— 成为鳞状细胞癌。 尽管多年来防晒霜的使用有所增加,但皮肤癌的发病率仍在持续上升。有两个障碍 对下一代防晒霜开发的影响: 1)现有产品的紫外线防护程度不够 市场,包括强效无机紫外线防护剂,如 TiO2 和 ZnO,以及 2) 这些无机防护剂 产生活性氧 (ROS),与配方中或皮肤上的有机化合物结合,形成 有害 副产品。多孔配位网络材料(例如 MOF)的最新进展可以满足 提高紫外线防护的广度和强度,同时捕获有毒的活性氧和自由基 在太阳辐射下产生的副产品。 在第一阶段,framergy 将通过紫外线吸光度测试为组合物选择最佳的钛 MOF, 吸附热测试、水稳定性测试和受控粒度合成。此外,framergy 将占据首位 向下和自下而上的方法来展示 MOF 的有机过氧化物清除性能。贝勒 医学院将通过在二维细胞模型中进行生物实验来协助这项技术开发活动 测量 UV 照射对 DNA 损伤和 ROS 产生的影响,无论是否应用 MOF。 这些测定将是基于成像的、中等和高通量的自动化实验,与单细胞相结合 分析。这将有助于阐明 MOF 在预防紫外线诱发的黑色素瘤中的作用。在 3D 中测试 MOF 一期和二期的皮肤模型将在临床前研究之前进一步强化结果。 在第二阶段期间,framergy和BCM团队将与德克萨斯州临床前研究所(Texas A&M 大学)进行临床前试验,进行细胞毒性和光基因毒性研究以过渡产品 从细胞水平到大型动物临床前试验的开发活动。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

R. OSMAN K. OZDEMIR其他文献

R. OSMAN K. OZDEMIR的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

Development of Selective Oxidative Biocatalytic Methods
选择性氧化生物催化方法的发展
  • 批准号:
    10606798
  • 财政年份:
    2023
  • 资助金额:
    $ 38.46万
  • 项目类别:
Identification and characterization of chemical probes for interrogation of the NEK family of kinases in cancer
用于研究癌症中 NEK 激酶家族的化学探针的鉴定和表征
  • 批准号:
    10503430
  • 财政年份:
    2022
  • 资助金额:
    $ 38.46万
  • 项目类别:
Molecular mechanisms for sorting lysosomal proteins
溶酶体蛋白分选的分子机制
  • 批准号:
    10521596
  • 财政年份:
    2022
  • 资助金额:
    $ 38.46万
  • 项目类别:
Molecular mechanisms for sorting lysosomal proteins
溶酶体蛋白分选的分子机制
  • 批准号:
    10662534
  • 财政年份:
    2022
  • 资助金额:
    $ 38.46万
  • 项目类别:
Structure-Activity Based Mechanistic Insights into Cleavage Chemistry by Self-Cleaving Nucleolytic Ribozymes
基于结构-活性的自裂解核酶裂解化学的机理见解
  • 批准号:
    10684151
  • 财政年份:
    2022
  • 资助金额:
    $ 38.46万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了