H2A Developmental Core

H2A 发展核心

• 批准号: 10084614
• 负责人: Gregory D Kirk
• 金额: $ 7.71万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10084614
• 关键词: Advocate; Africa; Africa South of the Sahara; African; Age; Award; Career Mobility; Clinical; Clinical Research; Collaborations; Complement; Country; Development; Fostering; Funding; Goals; HIV; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Individual; Infection; Intercept; Interruption; Investments; Lead; Link; Malignant Neoplasms; Malignant neoplasm of liver; Medical; Mentors; Mentorship; Mission; Patients; Peer Review; Pilot Projects; Play; Primary carcinoma of the liver cells; Process; Publications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Schistosoma mansonii infection; Senegal; Talents; Training Activity; Training Programs; Uganda; Universities; anticancer research; base; career; career development; chronic infection; design; faculty mentor; global health; innovation; next generation; peer; programs; recruit; senior faculty; skills; success

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. We will accomplish this objective by developing local capacity and performing important research. The H2A Scholar Award provides synergistic funding to early-stage African investigators for both individual career development activities and a mentored pilot project utilizing the substantive Consortium resources. Designation of Scholars will alternate yearly between Uganda and Senegal and opportunities to link across countries and with Hopkins will actively be pursued. Our approach of providing early-stage African investigators with substantive pilot project resources and pairing them with a Hopkins mentor will maximize the return on investment. The ultimate goal is to develop a cadre of talented, qualified African investigators to serve as leaders in the field of HIV and HCC research.

肝细胞癌 (HCC) 是非洲一种非常常见且致命的癌症，随着艾滋病毒患者的生存 时间越长，HCC 负担可能会增加。在之前的研究中，我们的团队发现了乙型肝炎的慢性感染 C 病毒（HBV、HCV）、HIV 和曼氏血吸虫病是 HCC 的独立危险因素。比较的 与美国相比，撒哈拉以南非洲地区的 HCC 发病年龄更小，阶段更晚期，生存期仅为 几个月。提议在马凯雷雷大学的同事之间建立东非和西非伙伴关系 乌干达、塞内加尔范恩大学和约翰·霍普金斯大学专注于艾滋病毒和肝细胞 非洲癌症 (HCC)：H2A 联盟。建立在长期合作研究、指导的基础上 以及两国的临床活动，我们的首要目标是减轻亚裔 HCC 的沉重负担 撒哈拉非洲。我们主张使用适当的医疗方法研究癌症拦截策略 中断或扭转这些引起 HCC 的感染的影响。我们将通过以下方式实现这一目标 发展当地能力并开展重要研究。 H2A 学者奖提供协同作用 为早期非洲研究人员提供资金，用于个人职业发展活动和指导 利用大量财团资源的试点项目。学者的任命将每年轮换 乌干达和塞内加尔之间的联系以及跨国家和与霍普金斯大学联系的机会将积极 追击。我们为早期非洲调查人员提供实质性试点项目资源的方法 并将他们与霍普金斯大学的导师配对将最大限度地提高投资回报。最终目标是发展 一支由才华横溢、合格的非洲研究人员组成的骨干队伍，将成为艾滋病毒和肝癌研究领域的领导者。