Lung cancer in East Africa and the relationship to HIV-1 infection: epidemiology, molecular characterization and imaging

东非肺癌及其与 HIV-1 感染的关系：流行病学、分子特征和影像学

基本信息

批准号：
10084623
负责人：
STANTON L. GERSON
金额：
$ 102.47万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-21 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10084623
关键词：
Address Advocacy Africa African Artificial Intelligence Cancer Burden Cancer Diagnostics Cancer Research Network Caring Clinical Collaborations Country Detection Development Diagnosis Diagnostic Services Diagnostic radiologic examination Disease Disease Outcome Epidemiology Evaluation Future Granulomatous Guidelines HIV HIV Infections HIV-1 Histologic Image Immunotherapy Incidence Individual Infection Institution Lead Leadership Lung Lung Capacity Machine Learning Malignant neoplasm of lung Mentors Molecular Molecular Epidemiology Molecular Profiling Outcome Pathology Patients Population Prevalence Radiology Specialty Research Personnel Risk Role Sampling Specimen Tanzania Tissues Training Tuberculosis Uganda actionable mutation anticancer research base biobank cancer care cancer diagnosis clinical Diagnosis clinical care clinical epidemiology improved instrumentation intelligent algorithm lung cancer screening lung imaging radiological imaging scale up screening program targeted treatment

项目摘要

The molecular epidemiology of lung cancer in Africa is almost completely unknown, yet molecular profiling and institution of targeted therapy is now standardly used to influence care in patients with actionable mutations. HIV- infection is associated with a markedly increased risk of lung cancer, but its association with lung cancer and how it influences disease outcomes is not well studied. The capacity to correctly diagnose lung cancer on radiological images, tissue specimen acquisition, and subsequent histologic confirmation compounds the problem of under and misdiagnosis of lung cancer in Africa, especially with the prevalence and often presumptive clinical diagnosis of tuberculosis infection. In this consortium proposal, we therefore seek to address the above stated problems by 1) establishing national lung cancer diagnostic referral networks in Uganda and Tanzania, which will allow for improved detection of lung cancer and, hence decrease the lung cancer burden; 2) investigating the role of HIV-1 infection on the incidence and outcomes of lung cancer in the region; 3) determining the molecular profile of lung cancer in East African countries in order to facilitate advocacy for scale- up of targeted therapies (including immune-based therapies); 4) building capacity for lung cancer diagnosis and care in terms of improving imaging, pathology, radiology and tissue acquisition and clinical care of lung cancer 5) creating a lung cancer research collaboration that will build capacity through mentoring of junior researchers for future leadership in the field. At the end of this project, we envision an African-led lung cancer research network, clinical expertise for sample acquisition and care, improved pathology and radiology diagnostics services, a lung cancer screening program, and a large biorepository that should support lung cancer research in the region for many years to come.

非洲肺癌的分子流行病学几乎是完全未知的，但分子分析和现在，标准地使用了靶向疗法的机构来影响可起诉突变患者的护理。艾滋病病毒- 感染与肺癌的风险显着增加有关，但它与肺癌和它如何影响疾病结果。正确诊断肺癌的能力放射学图像，组织样本的获取和随后的组织学确认化合物化合物非洲肺癌的不足和误诊的问题，尤其是患病率，通常是推定的结核病感染的临床诊断。因此，在该联盟提案中，我们寻求解决上述问题 1）在乌干达和坦桑尼亚建立全国肺癌诊断推荐网络，提出问题。这将允许改善肺癌的检测，从而减轻肺癌负担； 2）研究HIV-1感染对该地区肺癌的发病率和结局的作用； 3）确定东非国家肺癌的分子特征，以促进宣传规模靶向疗法（包括基于免疫疗法）； 4）肺癌诊断和在改善成像，病理学，放射学和组织获取以及肺癌临床护理方面的护理 5）建立肺癌研究合作，该合作将通过指导初级研究人员来增强能力为了将来在该领域的领导。在该项目的结尾，我们设想了一项非洲领导的肺癌研究网络，样品获取和护理的临床专业知识，改进的病理和放射学诊断服务，肺癌筛查计划以及应支持肺癌研究的大型生物座在该地区多年。