Early Psychosocial Intervention and Child and Parent Cardiovascular Disease Risk

早期心理社会干预与儿童和家长心血管疾病风险

• 批准号: 10083755
• 负责人: Hannah Milena Caroline Schreier
• 金额: $ 59.88万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-05 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10083755
• 关键词: Adult; Affect; Age; Aggressive behavior; Atherosclerosis; Autopsy; Behavioral; Biological Markers; Birth Weight; Blood; Blood Pressure; Cardiovascular Diseases; Cessation of life; Child; Child Development; Child Mental Health; Child Rearing; Chronic; Climate; Collection; Conflict (Psychology); Data; Data Collection; Development; Environment; Event; Experimental Designs; Exposure to; Family; Family dynamics; Fetus; Foundations; Funding; Future; Health; Home; Home visitation; Individual; Infection; Inflammation; Inflammatory; Intervention; Intervention Studies; Intervention Trial; Life; Link; Longevity; Low Birth Weight Infant; Measures; Mediating; Mental Depression; Mental Health; Metabolic; Methods; Modeling; National Institute of Child Health and Human Development; Observational Study; Outcome; Parents; Participant; Pathway interactions; Pattern; Perinatal; Personal Satisfaction; Physiological; Plant Roots; Population; Prevention; Prevention strategy; Problem behavior; Psychological Stress; Psychosocial Factor; Psychosocial Influences; Questionnaires; Randomized Controlled Trials; Research; Risk; Risk Factors; Risk Marker; Role; Sampling; Scientist; Socioeconomic Status; Spottings; Stress; System; Testing; United States; base; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular risk factor; cost; disease disparity; expectation; experience; experimental study; family influence; health disparity; improved; innovation; interpersonal conflict; intervention effect; maternal obesity; minimally invasive; novel; parental influence; perinatal intervention; physical conditioning; post intervention; psychosocial; randomized trial; socioeconomics; therapy design

Project Summary/Abstract The roots of cardiovascular disease (CVD), which is responsible for 32% of all deaths in the U.S., can be found during the early years, beginning perinatally. Although psychosocial interventions in populations across a wide age range have been shown to improve behavioral, mental health, and physical health outcomes, the development of effective early CVD prevention strategies and a deeper understanding of the ways in which psychosocial family factors interact to promote or reduce CVD risk are needed. The proposed project will build on the Family Foundations (FF) intervention, an ongoing NICHD-funded (PI: Feinberg, HD058529) randomized controlled trial of a perinatal intervention focused on coparenting, to examine the psychosocial pathways within the family that influence child and parent CVD risk. Additionally, we will examine potential intervention effects of FF on child and parent CVD risk. As part of the proposed project, we will augment the planned home visits (N = 294 families) which include questionnaire and family interaction data collection by adding the collection of baseline blood pressure, dried blood spot samples for the assessment of metabolic and inflammatory CVD risk markers, and important potential moderators of CVD risk. First, using these data and taking advantage of data available from three previous waves of data collection, we will develop models of interactive psychosocial influences on parent and child CVD risk. Specifically, this will include the consideration of child factors (e.g., behavioral problems), parent factors (e.g., depression), and family climate factors (e.g., parenting quality, family chaos and conflict), which we expect to interact and also contribute to CVD risk in unique ways. Second, we will test the extent to which these child, parent, and family factors mediate any effect of the FF intervention on CVD. Third, we will examine whether key external risk factors (parents’ lifetime socioeconomic status (SES) and adversity and children’s lifetime SES and birth weight) moderate any associations between child, parent, and family factors and CVD risk and whether they moderate main effects of the intervention on CVD risk. This research will be conducted by an interdisciplinary team of scientists who specialize in intervention research, psychosocial influences on health, minimally invasive field-based biomarker collection, and socioeconomic health disparities. The data resulting from this project will increase our understanding of the pathways through which the psychosocial family environment influences CVD risk and whether a psychosocial intervention can reduce CVD risk. By examining the moderating role of lifetime adversity and SES, the study will further inform future intervention research to unlock the potential of such interventions to reduce SES-based CVD disparities.

项目摘要/摘要 可以发现造成美国所有死亡的32％的心血管疾病（CVD）的根源 在早期，从围产期开始。虽然对人群的社会心理干预措施 已显示年龄范围可以改善行为，心理健康和身体健康成果， 制定有效的早期CVD预防策略，并更深入地了解 需要促进或减少CVD风险的社会心理家庭因素。拟议的项目将建立 在家庭基础（FF）干预中，正在进行的NICHD资助（PI：Feinberg，HD058529）随机 围产期干预措施的对照试验着重于共同，以检查内部的社会心理途径 影响儿童和父母CVD风险的家庭。此外，我们将检查潜在的干预效果 FF关于儿童和父母CVD风险的ff。作为拟议项目的一部分，我们将增加计划的家庭访问 （n = 294个家庭），其中包括问卷和家庭互动数据收集，通过添加收集 基线血压，干点样品，用于评估代谢和炎症CVD风险 标记和CVD风险的重要潜在主持人。首先，使用这些数据并利用数据 从以前的三波数据收集浪中获得，我们将开发交互式心理社会的模型 对父母和子女CVD风险的影响。具体而言，这将包括对儿童因素的考虑（例如 行为问题），父母因素（例如抑郁症）和家庭气候因素（例如，育儿质量， 家庭混乱和冲突），我们期望与之互动，并以独特的方式促进CVD风险。第二， 我们将测试这些孩子，父母和家庭因素介导FF干预的任何影响的程度 在CVD上。第三，我们将研究关键的外部风险因素（父母的终身社会经济地位（SES））是否是否 冒险和儿童的终生SE和出生体重）调节孩子，父母， 以及家庭因素和CVD风险，以及它们是否适应干预对CVD风险的主要影响。这 研究将由专门从事干预研究的科学家跨学科团队进行， 对健康的影响，基于现场的生物标志物收集和社会经济的影响 健康差异。该项目产生的数据将增加我们对路径的理解 心理社会环境会影响CVD风险以及社会心理干预是否可以 降低CVD风险。通过检查终生广告和SES的调节作用，该研究将进一步信息 未来的干预研究以释放这种干预措施减少基于SES的CVD差异的潜力。