Associations of Neighborhood Green Space and Social Disadvantage with Stress-Sensitive Inflammatory Biomarkers

邻里绿地和社会劣势与压力敏感炎症生物标志物的关联

• 批准号: 10083225
• 负责人: Laken Camille Roberts
• 金额: $ 4.6万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10083225
• 关键词: Acute-Phase Proteins; Address; Adult; Affect; African American; Age; Area; Attenuated; Baltimore; Biological; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion Molecules; Characteristics; Cities; Cohort Studies; Communities; Crime; Cross-Sectional Studies; Data; Data Analyses; Data Reporting; Disease; Economics; Elderly; Environment; Environmental Exposure; Exposure to; Female; Foundations; Functional disorder; Geology; Government Agencies; Green space; Health; Health Benefit; Heart; Hospitalization; Hydrocortisone; Hypothalamic structure; Impaired cognition; Individual; Inflammatory; Institution; Intercellular adhesion molecule 1; Interleukin-1 beta; Interleukin-6; Intervention; Lead; Link; Maps; Measures; Medical; Memory; National Heart, Lung, and Blood Institute; Neighborhoods; Obesity; Outcome; Participant; Patient Self-Report; Physical activity; Physiological; Pituitary Gland; Population; Prevention strategy; Productivity; Public Health; Relaxation; Research; Resources; Risk Factors; Risk Reduction; Role; Safety; Salivary; Sampling; Serum; Services; Social Conditions; Social Disorganizations; Social Interaction; Stress; TNF gene; Testing; Training; United States; Urban Community; Urban Developments; Vascular Cell Adhesion Molecule-1; aged; allostatic load; biological adaptation to stress; biological systems; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; community intervention; cost; cytokine; density; deprivation; disease disparity; experience; hazard; health difference; healthy lifestyle; human old age (65+); indexing; land cover; middle age; mortality; neighborhood association; physical inactivity; policy implication; programs; psychosocial; residence; resilience; response; skills; social; social capital; social determinants; social disadvantage; social health determinants; social stress; theories; therapy development; urban dwelling; urban planning

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is a major public health concern that affected 41% of the United States population and cost $555 billion in medical spending and lost productivity in 2016. Prevention strategies that intervene on social determinants of health, such as neighborhood environmental characteristics, are one approach to decreasing the growing burden of CVD. Neighborhood green spaces, including parks, recreational areas, and vegetation, are modifiable and important neighborhood factors have been associated with lower CVD risk and better physiologic outcomes. Green spaces may protect against CVD by mitigating stress through physical activity, relaxation, and positive social interactions that reduce individuals’ exposure to stressful social conditions. Neighborhood social disadvantage, measured as neighborhood psychosocial hazards comprised of social disorganization, safety, physical disorder, and economic deprivation, likely provokes a stress response that may lead to hypothalamic–pituitary–adrenocortical (HPA) axis dysfunction with regular exposure. Psychosocial hazards have been associated with increased CVD risk and higher levels of stress sensitive pro-inflammatory biomarkers. The health benefits of neighborhood green space suggest it may serve as a potential resilience factor against neighborhood social disadvantage. The proposed cross-sectional study will examine associations among neighborhood green space, neighborhood social disadvantage, and stress sensitive pro-inflammatory biomarkers in a sample of 624 urban-dwelling, middle-aged and older adults. This study is a secondary data analysis of the Baltimore Memory Study, a cohort study that investigated determinants of cognitive decline in 1,140 Baltimore City residents ages 50 to 70-year-old from 65 contiguous city neighborhoods (R01 AG19604, PI: B. Schwartz). Study data will be paired with satellite maps of vegetated land cover from the United States Geological Service to measure green space. The specific aims of the proposed study are to test: (1) the association between neighborhood green space and stress sensitive pro-inflammatory biomarkers; (2) the association between neighborhood social disadvantage and stress sensitive pro-inflammatory biomarkers; and (3) whether neighborhood green space modifies the association between neighborhood social disadvantage and stress sensitive pro-inflammatory biomarkers. These findings may help clarify the role of neighborhood green spaces as a modifiable neighborhood resilience factor that can be targeted for community-level interventions to reduce CVD risk. This proposed study aligns with the National Heart, Lung, and Blood Institute’s priorities to investigate factors that account for differences in health among populations and to understand how environmental exposures and social determinants modulate biological systems and promote resilience. The proposed training plan is foundational to a program of research focused on understanding social and environmental contributors to cardiovascular health and developing skills to create targeted interventions that promote heart-healthy lifestyles.

项目摘要/摘要 心血管疾病（CVD）是一个主要的公共卫生问题，影响了美国41％的人口 2016年的医疗支出耗资5550亿美元，生产力降低了。 健康的社会决定者，例如邻里环境特征，是一种方法 减少CVD燃烧的日益增长。邻里绿色空间，包括公园，娱乐区和 植被，是可修改的，重要的邻里因素与CVD风险较低和 更好的生理结果。绿色空间可以通过身体来缓解压力来防止CVD 活动，放松和积极的社交互动，以减少个人承受压力的社会状况。 社区社会灾难，以社会的邻里心理社会危害衡量 混乱，安全性，身体障碍和经济剥夺，可能会引起压力反应 导致下丘脑 - 垂体 - 肾上腺皮质（HPA）轴功能障碍，并定期暴露。社会心理 危害与CVD风险增加和更高水平的压力敏感性促炎性有关 生物标志物。邻里绿色空间的健康益处表明它可能是一种潜在的弹性 反对社区社会劣势的因素。拟议的横断面研究将检查关联 在邻里绿色空间中，社区社会灾难和压力敏感的促炎 在624个城市居民，中年和老年人样本中的生物标志物。这项研究是二级数据 巴尔的摩记忆研究的分析，这是一项研究的研究，研究了确定性的认知能力下降 来自65个连续的城市社区的1,140名巴尔的摩市居民50至70岁的居民（R01 AG19604， PI：B。Schwartz）。研究数据将与美国的植被土地覆盖物的卫星图配对 测量绿色空间的地质服务。拟议研究的具体目的是测试：（1） 邻里绿色空间与压力敏感的促炎生物标志物之间的关联； （2） 邻里社会灾难与压力敏感的促炎生物标志物之间的关联；和 （3）邻里绿色空间是否改变了社区社会灾难与 压力敏感的促炎生物标志物。这些发现可能有助于确定邻里绿色的作用 空间是可修改的邻里弹性因素，可以针对社区级干预措施 降低CVD风险。这项拟议的研究与国家心脏，肺和血液研究所的优先事项保持一致 调查说明人口健康差异的因素，并了解如何 环境暴露和社会决定者调节生物系统并促进弹性。这 拟议的培训计划是一项研究计划的基础，专注于了解社会和 心血管健康和发展技能的环境贡献者，以创造有针对性的干预措施 促进健康的生活方式。