Hosted Commercial In-Life Data Collection and Management System for the National Toxicology Program (Subproject 1 (Support for Cancer Research by NTP)

主持国家毒理学计划的商业生命数据收集和管理系统（子项目1（NTP支持癌症研究）

• 批准号: 10117025
• 负责人: DAVID WHEELER
• 金额: $ 24.33万
• 依托单位: INSTEM LSS (NORTH AMERICA) LIMITED
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10117025
• 关键词: Amendment; Back; Contracts; Data; Data Collection; Data Management Resources; Data Reporting; Databases; Development; Environment; Human; Incidence; Institutes; Internet; Laboratories; Laboratory Personnel; Laboratory Study; Life; Management Information Systems; Methods; Mission; Modernization; Molecular Biology; Monitor; National Institute of Environmental Health Sciences; National Toxicology Program; Pathologist; Pathology; Pathology Report; Public Health; Reporting; Research; Role; Running; Science; Scientist; Secure; Survival Analysis; System; Testing; Toxicology; United States Dept. of Health and Human Services; United States National Institutes of Health; anticancer research; base; carcinogenicity; central database; design; disability; environmental agent; human disease; new technology; programs; time use; tool

The National Institute of Environmental Health Sciences (NIEHS) is one of 27 Institutes and Centers of the National Institutes of Health (NIH), Department of Health and Human Services (DHHS). The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease. The Division of the National Toxicology Program (NTP) is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology. The NTP maintains an objective, science-based approach in dealing with critical issues in toxicology and is committed to using the best science available to prioritize, design, conduct, and interpret its studies. To that end, the NTP is continually evolving to remain at the cutting edge of scientific research and to develop and apply new technologies. In carrying out its mission, the NTP studies the effects of environmental agents in laboratory studies, which are performed predominantly at contract laboratories and then reviewed by the NTP. The NTP requires a hosted data management system to collect data from multiple laboratories and host the data in a secure central database which the NTP scientists can access in order to review and analyze the data. The system shall use the internet to transmit the collected data securely back to the hosted database. This system shall meet requirements for use in a GLP-regulated environment. DNTP selected Provantis LIMS hosted by Instem as the system to use for this purpose.

美国国家环境健康科学研究所 (NIEHS) 是美国卫生与公众服务部 (DHHS) 下属的美国国立卫生研究院 (NIH) 的 27 个研究所和中心之一。 NIEHS 的使命是通过了解环境如何影响人类疾病的发生和进展来减轻人类疾病和残疾的负担。 国家毒理学计划 (NTP) 部门是一个跨机构计划，其使命是通过开发和应用现代毒理学和分子生物学工具来评估公共卫生问题的因素。 NTP 在处理毒理学关键问题时保持客观、基于科学的方法，并致力于利用现有的最佳科学来确定其研究的优先顺序、设计、进行和解释。为此，NTP 不断发展，以保持科学研究的前沿并开发和应用新技术。 在执行其使命时，NTP 在实验室研究中研究环境因素的影响，这些研究主要在合同实验室进行，然后由 NTP 进行审查。 NTP 需要一个托管数据管理系统来收集来自多个实验室的数据，并将数据托管在安全的中央数据库中，NTP 科学家可以访问该数据库以审查和分析数据。 系统应使用互联网将收集的数据安全地传输回托管数据库。 该系统应满足在 GLP 监管环境中使用的要求。 DNTP 选择由 Instem 托管的 Provantis LIMS 作为用于此目的的系统。