Implications of metabolism on healthy aging in African and Caucasian Americans: the Health ABC study
新陈代谢对非洲裔和白种裔美国人健康老龄化的影响:Health ABC 研究
基本信息
- 批准号:10118476
- 负责人:
- 金额:$ 23.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Alzheimer-type (AD) and non-AD dementias and neurocognitive impairment have origins in dysregulated me-
tabolism, leading to consideration of dementia as a “type 3 diabetes” phenotype. A wide array of basic labora-
tory, model systems-based, and human investigations around identifying precise metabolic defects as the core
of AD/non-AD dementias have emerged. A critical feature of studies attempting to identify a metabolic basis of
neurocognitive dysfunction is the application of a broad assessment of metabolism to a well phenotyped hu-
man cohort with dementia and related outcomes. As part of R01AG059729, Drs. Shah, Newman, Murthy and
Clish have been performing metabolite profiling in a biracial subsample of the Healthy Aging and Body Com-
position Study (Health ABC) to identify metabolic pathways relevant to healthy aging. While the parent study
includes some neurocognitive measures, it only assays a subsample within Health ABC for lipid and lipid me-
diators, the key metabolites felt to be relevant to AD and related dementias. Based on data suggesting the
emerging importance of inflammation and lipid abnormalities in AD, the study team is requesting supplemental
funds as part of this application to complete lipid and lipid intermediate metabolite profiling to facilitate (1) wider
scientific discovery in AD and AD-related phenotypes and (2) integration with other metabolite modes already
completed in Health ABC to provide a wider description of the metabolic abnormalities important in the life-
course of neurocognitive dysfunction and AD. We hypothesize that lipid and lipid mediators will be associated
with phenotypes and phenotypic groups central to AD and may facilitate discovery of potentially intervenable
pathways at the heart of AD and AD-related neurocognitive dysfunction. To address this hypothesis, we will
perform metabolite profiling in a wider sample size in Health ABC for lipid (C8 positive) and lipid mediators
(C18 negative) to identify metabolites and encoded pathways associated with clinical and imaging-based de-
mentia endpoints. In Aim 1, we will identify lipid and lipid mediator metabolite signatures associated with sub-
sequent cognitive decline, preclinical AD phenotypes, and dementia. In Aim 2, we will identify association of
lipid and lipid mediators with selected MRI markers of dementia previously reported. In Aim 3, we will test how
metabolic pathways linked to dementia differ by race and sex and how these metabolite signatures are related
to diet, fitness, activity, and adiposity, key modifiable lifestyle features linked to improved neurocognitive func-
tion. This supplement is unique in that it has been conceived and constructed in full collaboration with the Na-
tional Institutes of Aging (Dr. Luigi Ferrucci and Qu Tian), experts in aging and AD and substantially augments
the sample size for metabolite profiling covered by the parent R01 grant, while leveraging its substantial re-
sources. Completion would afford the scientific community a wider array of quantitative metabolic phenotyping
to address AD and AD-related phenotypes, directly addressing NOT-AG-20-008 by integrating efforts in ongo-
ing studies of aging to address neurocognitive endpoints relevant to AD.
阿尔茨海默氏症型(AD)和非AD痴呆症和神经认知障碍起源于失调
Tabolism,导致将痴呆视为“ 3型糖尿病”表型。各种各样的基本实验
保守党,基于模型的系统和人类投资围绕确定精确的代谢缺陷为核心
出现了广告/非AD痴呆症。试图确定代谢基础的研究的关键特征
神经认知功能障碍是对新陈代谢的广泛评估的应用
与痴呆症和相关结果的人队列。作为R01AG059729的一部分,Drs。 Shah,Newman,Murthy和
克里什(Clish
位置研究(Health ABC)确定与健康衰老有关的代谢途径。父母学习
包括一些神经认知措施,它仅测定健康ABC中的子样本的脂质和脂质me-
养子,关键的代谢产物认为与AD和相关痴呆症有关。根据暗示的数据
研究小组的新兴感染和脂质异常的重要性是要求补充
资金作为本申请的一部分,以完成脂质和脂质中间代谢物分析以促进(1)Wilder
AD和AD相关表型中的科学发现以及(2)与其他代谢物模式的整合
在卫生ABC中完成,以提供对生活中重要的代谢异常的更广泛描述 -
神经认知功能障碍和AD的过程。我们假设脂质和脂质介质将与
具有AD中心的表型和表型组,并可能有助于发现潜在的可干预
AD核心和与AD相关的神经认知功能障碍的途径。为了解决这一假设,我们将
在健康ABC中,对脂质(C8阳性)和脂质介质进行代谢物分析,以更广泛的样本量进行
(C18负)确定与临床和基于成像的DE-相关的代谢物和编码途径
精神病终点。在AIM 1中,我们将确定与子 -
依次的认知下降,临床前AD表型和痴呆症。在AIM 2中,我们将确定
先前报道的具有痴呆症的精选MRI标记的脂质和脂质介质。在AIM 3中,我们将测试如何
与种族和性别不同的痴呆症与痴呆症相关的代谢途径以及这些代谢物特征如何相关
为了饮食,健身,活动和肥胖,关键的可修改生活方式特征与改善神经认知功能有关
tion。这种补充是独一无二的
衰老学院(Luigi Ferrucci博士和Qu Tian博士),衰老和广告专家
代谢物分析的样本量由父级R01赠款涵盖,同时利用其大量重新
来源。完成将为科学界提供更广泛的定量代谢表型
为了解决AD和与广告相关的表型,通过将努力整合到Ongo中直接解决非AG-20-008
衰老研究以解决与AD相关的神经认知终点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
Venkatesh Locharla Murthy其他文献
METABOLIC SIGNATURES OF CARDIAC DYSFUNCTION ARE ASSOCIATED WITH MULTIMORBIDITY AND POST-TRANSCATHETER AORTIC VALVE IMPLANTATION MORTALITY
- DOI:10.1016/s0735-1097(23)04460-110.1016/s0735-1097(23)04460-1
- 发表时间:2023-03-072023-03-07
- 期刊:
- 影响因子:
- 作者:Andrew Perry;Shilin Zhao;Venkatesh Locharla Murthy;Deepak K. Gupta;William Fuller Fearon;Juyong Brian Kim;Samir R. Kapadia;Dharam J. Kumbhani;Linda D. Gillam;Brian K. Whisenant;Nishath Quader;Alan Zajarias;Ravinder Mallugari;Daniel Eugene Clark;Jay Patel;Holly Gonzales;Frederick G.P. Welt;Anthony A. Bavry;Megan Coylewright;Robert N. PianaAndrew Perry;Shilin Zhao;Venkatesh Locharla Murthy;Deepak K. Gupta;William Fuller Fearon;Juyong Brian Kim;Samir R. Kapadia;Dharam J. Kumbhani;Linda D. Gillam;Brian K. Whisenant;Nishath Quader;Alan Zajarias;Ravinder Mallugari;Daniel Eugene Clark;Jay Patel;Holly Gonzales;Frederick G.P. Welt;Anthony A. Bavry;Megan Coylewright;Robert N. Piana
- 通讯作者:Robert N. PianaRobert N. Piana
MACHINE LEARNING MODEL TO PREDICT MYOCARDIAL BLOOD FLOW AND IMPORTANT CLINICAL OUTCOMES FROM PATIENTS’ ELECTROCARDIOGRAMS USING A PET DATA REGISTRY
- DOI:10.1016/s0735-1097(24)04352-310.1016/s0735-1097(24)04352-3
- 发表时间:2024-04-022024-04-02
- 期刊:
- 影响因子:
- 作者:Fares Alahdab;Maliazurina Saad;Ahmed Ibrahim Ahmed;Qasem Al-Tashi;Yushui Han;Muhammad Aminu;Venkatesh Locharla Murthy;Jia Wu;Mouaz H. Al-MallahFares Alahdab;Maliazurina Saad;Ahmed Ibrahim Ahmed;Qasem Al-Tashi;Yushui Han;Muhammad Aminu;Venkatesh Locharla Murthy;Jia Wu;Mouaz H. Al-Mallah
- 通讯作者:Mouaz H. Al-MallahMouaz H. Al-Mallah
IMPROVED QUANTITATIVE SPECT MYOCARDIAL PERFUSION IMAGING USING DEEP LEARNING-BASED ATTENUATION CORRECTION
- DOI:10.1016/s0735-1097(22)02183-010.1016/s0735-1097(22)02183-0
- 发表时间:2022-03-082022-03-08
- 期刊:
- 影响因子:
- 作者:Tomoe Hagio;Alexis Poitrasson-Rivière;Jonathan B. Moody;Jennifer M. Renaud;Liliana Arida-Moody;Ravi V. Shah;Edward P. Ficaro;Venkatesh Locharla MurthyTomoe Hagio;Alexis Poitrasson-Rivière;Jonathan B. Moody;Jennifer M. Renaud;Liliana Arida-Moody;Ravi V. Shah;Edward P. Ficaro;Venkatesh Locharla Murthy
- 通讯作者:Venkatesh Locharla MurthyVenkatesh Locharla Murthy
PYP QUANTIFICATION OF AMYLOID BURDEN IN TRANSTHYRETIN AMYLOID CARDIOMYOPATHY AND CORRELATION WITH ECHOCARDIOGRAM
- DOI:10.1016/s0735-1097(24)03402-810.1016/s0735-1097(24)03402-8
- 发表时间:2024-04-022024-04-02
- 期刊:
- 影响因子:
- 作者:Kaitlin Shinn;Yoav Hamer;Alexis Poitrasson-Rivière;Matheos Yosef;Chaitanya Madamanchi;Venkatesh Locharla MurthyKaitlin Shinn;Yoav Hamer;Alexis Poitrasson-Rivière;Matheos Yosef;Chaitanya Madamanchi;Venkatesh Locharla Murthy
- 通讯作者:Venkatesh Locharla MurthyVenkatesh Locharla Murthy
VALIDATION OF A MACHINE LEARNING MODEL TO PREDICT MYOCARDIAL BLOOD FLOW AND IMPORTANT CLINICAL OUTCOMES FROM PATIENTS’ ELECTROCARDIOGRAMS USING A SPECT DATA REGISTRY
- DOI:10.1016/s0735-1097(24)04566-210.1016/s0735-1097(24)04566-2
- 发表时间:2024-04-022024-04-02
- 期刊:
- 影响因子:
- 作者:Fares Alahdab;Maliazurina Saad;Ahmed Ibrahim Ahmed;Yushui Han;Qasem Al-Tashi;Muhammad Aminu;Venkatesh Locharla Murthy;Jia Wu;Mouaz H. Al-MallahFares Alahdab;Maliazurina Saad;Ahmed Ibrahim Ahmed;Yushui Han;Qasem Al-Tashi;Muhammad Aminu;Venkatesh Locharla Murthy;Jia Wu;Mouaz H. Al-Mallah
- 通讯作者:Mouaz H. Al-MallahMouaz H. Al-Mallah
共 5 条
- 1
Venkatesh Locharla...的其他基金
Molecular markers of early cardiometabolic health transitions in the CARDIA study
CARDIA 研究中早期心脏代谢健康转变的分子标记
- 批准号:1058134110581341
- 财政年份:2022
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
Metabolic architecture of insulin action in Southwest American Indians
西南美洲印第安人胰岛素作用的代谢结构
- 批准号:1054490010544900
- 财政年份:2020
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
Metabolic architecture of insulin action in Southwest American Indians
西南美洲印第安人胰岛素作用的代谢结构
- 批准号:1064780210647802
- 财政年份:2020
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
Implications of metabolism on healthy aging in African and Caucasian Americans: the Health ABC study
新陈代谢对非洲裔和白种裔美国人健康老龄化的影响:Health ABC 研究
- 批准号:1018667710186677
- 财政年份:2018
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
Implications of metabolism on healthy aging in African and Caucasian Americans: the Health ABC study
新陈代谢对非洲裔和白种裔美国人健康老龄化的影响:Health ABC 研究
- 批准号:99061559906155
- 财政年份:2018
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
Implications of metabolism on healthy aging in African and Caucasian Americans: the Health ABC study
新陈代谢对非洲裔和白种裔美国人健康老龄化的影响:Health ABC 研究
- 批准号:97505819750581
- 财政年份:2018
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
Implications of metabolism on healthy aging in African and Caucasian Americans: the Health ABC study
新陈代谢对非洲裔和白种裔美国人健康老龄化的影响:Health ABC 研究
- 批准号:1061790010617900
- 财政年份:2018
- 资助金额:$ 23.64万$ 23.64万
- 项目类别:
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