Sao Paulo-Minas Gerais Tropical Medicine Research Center for Chagas Disease Biomarker Discovery

圣保罗-米纳斯吉拉斯热带医学研究中心查加斯病生物标志物发现

• 批准号: 10115576
• 负责人: Ester Cerdeira Sabino
• 金额: $ 41万
• 依托单位: FUNDACAO FACULDADE DE MEDICINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115576
• 关键词: Antibodies; Biological Markers; Biological Specimen Banks; Blood donor; Cardiac; Cardiomyopathies; Central America; Cessation of life; Chagas Disease; Charge; Child; Childhood; Chronic; Clinical; Communities; Data; Data Collection; Data Storage and Retrieval; Databases; Development; Disease; Disease Outcome; Disease Progression; Electrocardiogram; Enrollment; Epidemiology; Evolution; Family member; Funding; Genetic; Genetic Predisposition to Disease; Goals; Heart; Individual; Infection; Inflammatory; Institutes; International; Knowledge; Latin America; Measures; MicroRNAs; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; Natural History; Parasitemia; Parasites; Parents; Participant; Patients; Pattern; Performance; Predictive Value; Prevalence; Prognosis; Prognostic Marker; Proteomics; Questionnaires; RNA; Research; Research Project Grants; Research Training; Risk; Saliva; Sampling; Sampling Studies; Scientist; Seroepidemiologic Studies; Serology; Surveys; Technology; Testing; Therapeutic Intervention; Time; Training Programs; Triatoma; Triatominae; Tropical Medicine; Trypanosoma cruzi; United States National Institutes of Health; Validation; Visit; Work; base; biomarker discovery; biomarker validation; chagasic cardiomyopathy; cohort; cytokine; data access; effective therapy; follow-up; genetic linkage; genome wide association study; high risk; indexing; insight; mRNA Expression; neglect; novel diagnostics; novel therapeutic intervention; novel therapeutics; prognostic value; programs; recruit; repository; sample collection; screening; seropositive; therapeutically effective; tool; transcriptome; transmission process; vector; vector transmission

PROJECT SUMMARY/ABSTRACT -OVERALL Chagas disease (ChD), caused by infection with the parasite Trypanosoma cruzi, remains one of the world's most neglected diseases with 5.7 million infected people, but only a single partially effective treatment. The lack of good biomarkers for active infection or clinical end-points poses a problem for assessing the performance of new drugs or therapeutic interventions. The Sao Paulo-Minas Gerais Tropical Medicine Research Center (SaMi-Trop) consists of a network of collaborating scientists in the States of Minas Gerais and Sao Paulo which has been established for the purpose of developing and conducting research projects on ChD biomarker discovery and validation. In this proposal, the center will develop three interrelated studies: Project 1 will study the natural history of ChD, in order to recognize prognostic markers related to the risk of progression to cardiopathy, cardiac complications and death. To that effect, we will characterize the clinical evolution of two large cohorts (REDS and SaMi-Trop) to assess the predictable values of biomarkers measured at cohort enrollment. Project 2 will assess if genetic susceptibility modulates disease development. We will use genome wide association study (GWAS) that will combine genetic data from ~5,500 individuals recruited by two NIH-sponsored studies (REDS and SaMi-Trop) and other studies funded by Brazilian Agencies (Bambui, Heart Institute). Project 3 will determine if T cruzi vectorial transmission is reemerging in the Northen Region of Minas Gerais State (a region considered free of domiciliary vector transmission since 2006). We will conduct a large-scale screening survey to detect T. cruzi antibody in schoolchildren’s saliva, and a survey with questionnaires applied to the children’s parents about the prevalence of infestation by triatominae vectors. Two cores (Administrative/Scientific Core and Database and Epidemiology Core) will support activities of the three projects, and will seek to sustain research training capacity for young Brazilian scientists

项目概要/摘要 - 总体 恰加斯病 (ChD) 由寄生虫克氏锥虫感染引起，仍然是世界上最严重的疾病之一 最被忽视的疾病有 570 万人感染，但只有一种治疗方法部分有效。 缺乏活动性感染或临床终点的良好生物标志物给评估感染带来了问题 新药或治疗干预措施的表现。 圣保罗-米纳斯吉拉斯州热带医学研究中心 (SaMi-Trop) 由以下网络组成： 米纳斯吉拉斯州和圣保罗州的合作科学家为 开发和开展 ChD 生物标志物发现和验证研究项目的目的。 在本提案中，该中心将开展三项相互关联的研究： 项目 1 将研究自然历史 ChD，为了识别与进展为心脏病风险相关的预后标志物，心脏 为此，我们将描述两个大队列（REDS）的临床演变。 和 SaMi-Trop）来评估队列项目 2 时测量的生物标志物的可预测值。 我们将使用全基因组关联研究来评估遗传易感性是否调节疾病的发展。 (GWAS) 将结合两项 NIH 资助的研究 (REDS) 招募的约 5,500 名个体的遗传数据 和 SaMi-Trop）以及由巴西机构（Bambui、心脏研究所项目 3）资助的其他研究。 确定米纳斯吉拉斯州北部地区（该地区 自2006年起被认为没有家庭媒介传播）我们将进行大规模筛查调查。 检测小学生唾液中的克氏锥虫抗体，并对儿童进行问卷调查 家长关于锥蝽媒介感染流行情况的两个核心（行政/科学核心）。 以及数据库和流行病学核心）将支持这三个项目的活动，并将寻求维持 巴西年轻科学家的研究培训能力

项目成果

Incremental Prognostic Value of Echocardiography to Brain Natriuretic Peptide in Patients with Chagas Cardiomyopathy from Endemic Areas.

超声心动图对流行地区恰加斯心肌病患者脑钠肽的增加预后价值。

• DOI: 10.1016/j.echo.2022.05.008
• 发表时间: 2022
• 期刊: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
• 作者: Maia,MarceloAlves;Sabino,EsterCerdeira;Oliveira,LeaCamposde;Oliveira,ClaudiaDiLorenzo;Cardoso,ClareciS;Maia,AnaIsabelNobre;Versiani,FellipeColaresPG;Silva,JoseLuizPadilhada;Ferreira,ArielaMota;Ribeiro,AntonioLuizP;Nun
• 通讯作者: Nun

A bibliometric review of drug repurposing.

• DOI: 10.1016/j.drudis.2018.01.018
• 发表时间: 2018-03
• 期刊: Drug discovery today
• 影响因子: 7.4
• 作者: Baker NC;Ekins S;Williams AJ;Tropsha A
• 通讯作者: Tropsha A

Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease.

• DOI: 10.1007/s10875-021-01000-y
• 发表时间: 2021-07
• 期刊: Journal of clinical immunology
• 影响因子: 9.1
• 作者: Ouarhache M;Marquet S;Frade AF;Ferreira AM;Ianni B;Almeida RR;Nunes JPS;Ferreira LRP;Rigaud VO;Cândido D;Mady C;Zaniratto RCF;Buck P;Torres M;Gallardo F;Andrieux P;Bydlowsky S;Levy D;Abel L;Cardoso CS;Santos-Junior OR;Oliveira LC;Oliveira CDL;Nunes MDC;Cobat A;Kalil J;Ribeiro AL;Sabino EC;Cunha-Neto E;Chevillard C
• 通讯作者: Chevillard C

Contextual influence on poor self-rated health in patients with Chagas disease: multilevel study.

• DOI: 10.1590/1413-81232022277.01682022
• 发表时间: 2022-07
• 期刊: CIENCIA & SAUDE COLETIVA
• 影响因子: 1.7
• 作者: Ferreira, Ariela Mota;Sabino, Ester Cerdeira;de Oliveira-da Silva, Lea Campos;Oliveira, Claudia Di Lorenzo;Cardoso, Clareci Silva;Pinho Ribeiro, Antonio Luiz;Damasceno, Renata Fiuza;Leite, Samara Fernandes;Vieira, Thallyta Maria;Pereira Nunes, Maria do Carmo;Haikal, Desiree Sant' Ana
• 通讯作者: Haikal, Desiree Sant' Ana

Lack of evidence of seronegative infection in an endemic area of Chagas disease.

缺乏恰加斯病流行区血清阴性感染的证据。

• DOI: 10.1590/s1678-9946201961011
• 发表时间: 2019
• 期刊: Revista do Instituto de Medicina Tropical de Sao Paulo
• 影响因子: 1.9
• 作者: Oliveira,LéaCamposde;Lee,Tzong-Hae;Ferreira,ArielaMota;Bierrenbach,AnaLuiza;Souza-Basqueira,Marcelade;Oliveira,CláudiaDiLorenzo;Cardoso,ClareciSilva;Moreira,CarlosHenriqueValente;Oikawa,MarcioK;Ribeiro,AntonioLuizP;Busch,
• 通讯作者: Busch,