Statistics Core

统计核心

• 批准号: 10116337
• 负责人: ROBERT J GRAY
• 金额: $ 339.98万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-29 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10116337
• 关键词: Address; American College of Radiology Imaging Network; Biometry; Computational Biology; Dana-Farber Cancer Institute; Data Analyses; Data Reporting; Development; Diagnostic Imaging; Eastern Cooperative Oncology Group; Lead; Leadership; Manuscripts; Methodology; Mission; Monitor; Outcome; Process; Reporting; Research; Research Personnel; Research Support; Safety; Structure; Therapeutic Trials; Time; Translational Research; Universities; Work; data management; design; experience; imaging study; programs; statistics

The Statistics core activities are performed by the Biostatistics Center of the ECOG-ACRIN Statistics and Data Management Center. The Biostatistics Center is responsible for design and analysis of all ECOG-ACRIN studies. The Biostatistics Center has two components, SDMC-DFCI at the Dana-Farber Cancer Institute, which has primary responsibility for therapeutic trials, and SDMC-Brown at Brown University, which has primary responsibility for diagnostic and imaging studies. The Center includes a group of highly experienced statisticians who are led by Drs. Constantine Gatsonis and Robert Gray. The Center also has expertise in computational biology and has access to leading experts in this field at DFCI and Brown. The research structure of ECOG-ACRIN is organized into a number of scientific committees, which are responsible for developing the Group's studies. ECOG-ACRIN statisticians are assigned to work with specific scientific committees. They participate fully in the development of scientific directions and collaborate on study concepts from the earliest discussions within the committees through the entire process of development. Statisticians are responsible for developing statistical designs and analysis plans to robustly address study's objectives. The Biostatistics Center is responsible for comprehensive monitoring of all EA studies, including producing reports for monitoring study progress and safety and producing confidential reports for the Data Safety Monitoring Committee, which include interim analyses of outcome when appropriate. Statisticians also produce comprehensive reports on study results at the completion of studies and collaborate with lead study investigators on the development of manuscripts. Statisticians also collaborate with investigators on design and analysis of the ECOG- ACRIN's translational science initiatives.

统计核心活动由ECOG-ACRIN统计的生物统计学中心进行 和数据管理中心。生物统计学中心负责设计和分析所有 ECOG-ACRIN研究。 Biostatistics中心有两个组件，SDMC-DFCI在Dana-Farber 癌症研究所（Cancer Institute）对治疗试验负有主要责任，而SDMC-Brown的SDMC-Brown 大学，对诊断和成像研究负有主要责任。中心包括一个 由博士领导的一群经验丰富的统计学家。君士坦丁·加特森（Constantine Gatsonis）和罗伯特·格雷（Robert Gray）。 该中心还具有计算生物学方面的专业知识，并可以与该领域的领先专家接触 在DFCI和Brown。 Ecog-Acrin的研究结构被组织成许多科学委员会，这些委员会是 负责发展小组的研究。 Ecog-acrin统计学家被分配 特定的科学委员会。他们完全参与了科学方向的发展 通过整个委员会中最早的讨论从整个委员会中的最早讨论中进行协作 发展过程。统计学家负责开发统计设计和分析 计划坚定解决研究的目标。生物统计学中心负责全面 监测所有EA研究，包括生产用于监视研究进度和安全性的报告 为数据安全监测委员会制作机密报告，其中包括临时 适当的结果分析。统计学家还提供有关研究的全面报告 研究完成后的结果，并与主要研究研究者合作开发 手稿。统计学家还与调查人员合作，就生态学的设计和分析进行了合作 Acrin的翻译科学计划。