HaloFilm: a spray-on, re-chargeable, re-applicable antimicrobial coating

HaloFilm：一种喷涂式、可充电、可重复涂抹的抗菌涂层

• 批准号: 10079763
• 负责人: Mingyu Qiao
• 金额: $ 25.03万
• 依托单位: HALOMINE, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-05 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10079763
• 关键词: Adhesions; Affect; Antibiotics; Antidotes; Antimicrobial Effect; Antimicrobial Resistance; Bacteria; Beds; Biological; Cessation of life; Charge; Chemicals; Chemistry; Chlorine; Clinical Trials; Consumption; Data; Development; Dopa; Effectiveness; Equipment; Evaluation; Film; Formulation; Goals; Hand; Health Care Costs; Health Personnel; Health care facility; Hospitals; Household; Human; In Vitro; Infection; Intellectual Property; Legal patent; Link; Medical Device; Methods; Mussels; Nosocomial Infections; Paint; Patient Discharge; Patients; Patients' Rooms; Phase; Polymers; Procedures; Property; Proteins; Protocols documentation; Reporting; Residual state; Resistance; Resistance development; Rubber; Safety; Sanitation; Silver; Skin; Source; Stainless Steel; Structure; Surface; System; Techniques; Testing; Thinness; Time; Touch sensation; Toxic effect; Universities; Vertebral column; Virus; Visual; antimicrobial; antimicrobial drug; base; cost; cost effective; cytotoxicity; efficacy testing; ethylene glycol; fungus; health care settings; healthcare-associated infections; in vitro testing; innovation; invention; meetings; microbial; migration; minimal risk; monomer; novel; pathogen; relative effectiveness; skin irritation; tool

Project Summary/Abstract In the US, about 1.7 million Healthcare-Associated Infections (HAls) occur in hospitals each year, resulting in 99,000 deaths and an estimated $20 billion in healthcare costs. According to previous reports, as much as one third of HAI cases can be attributed to environmental surfaces, namely “high touch” surfaces (e.g. bed rails, machine buttons, equipment), in a hospital. Self-sanitizing coatings, i.e. antimicrobial surfaces, are an ideal theoretical solution for eliminating persistent pathogens; however there has been no commercially available antimicrobial material which can fulfill all requirements of high-efficacy against pathogens: easy to apply, broad material compatibility, no pathogen resistance development, and cost-effective. That makes HaloFilm™ a breakthrough product. HaloFilm is a spray-on product that when dried leaves a thin transparent film on a surface. The film is a polymer composed of one monomer to stick to the surface, and another monomer that stabilizes chlorine, i.e. N-halamine. HaloFilm turns the surface into a chlorine battery so using even a household brand sanitizer will leave a surface covered with chlorine which can last longer than two weeks. HaloFilm has superior efficacy against pathogens compared to the most popular antimicrobial agent, silver, because it relies on the efficacy of chlorine which has decades of use, and broad-spectrum efficacy against pathogen without generating pathogens with resistance. In addition, we recently developed a formulation that include anti-fouling monomers, zwitterion moieties and poly(ethylene glycol). These additions to the polymer backbone mean that HaloFilm can be effective even without being charged with chlorine. This project will evaluate HaloFilm with these two anti-fouling monomers against HaloFilm without them. The best formulation will then be tested for efficacy and safety. HaloFilm is Halamine Inc.’s first product and is protected by exclusively licensed patents from Auburn University and Cornell University.

项目概要/摘要 在美国，每个医院大约发生 170 万起医疗相关感染 (HAls) 据估计，一年内导致 99,000 人死亡，医疗费用估计达 200 亿美元。 此前的报告显示，多达三分之一的医院感染病例可归因于环境问题 表面，即“高接触”表面（例如床栏、机器按钮、设备）， 自消毒涂层，即抗菌表面，是一种理想的理论解决方案。 消除持久性病原体；但是还没有商业可用的 能够满足高效对抗病原体的所有要求的抗菌材料：简单 适用范围广，材料相容性广，无病原菌耐药性发展，性价比高。 这使得 HaloFilm™ 成为一种突破性产品，它是一种喷涂产品。 干燥后在表面留下一层薄薄的透明薄膜，该薄膜是由一种聚合物组成的。 单体粘附在表面上，另一种单体可以稳定氯，即 N-卤胺。 HaloFilm 将表面变成氯电池，因此即使使用家用品牌的消毒剂也可以 让表面覆盖氯，其使用寿命可以超过两周。 与最流行的抗菌剂银相比，对病原体具有卓越的功效， 因为它依赖于已使用数十年的氯的功效，并且具有广谱性 对抗病原体的功效，而不产生具有抗药性的病原体。 此外，我们最近开发了一种包含防污单体、两性离子的配方 聚合物主链上的这些添加物意味着： HaloFilm 即使不充氯也能发挥作用，该项目将进行评估。 含有这两种防污单体的 HaloFilm 与不含它们的 HaloFilm 相比。 然后将测试配方的功效和安全性。 HaloFilm 是 Halamine Inc. 的第一个产品，并受到以下公司独家许可专利的保护： 奥本大学和康奈尔大学。