Infant Temperament and Early Infant Growth and Child Overweight in GDM Offspring

GDM子代的婴儿气质与早期婴儿生长和儿童超重

基本信息

批准号：
8766265
负责人：
Erica Pauline Gunderson
金额：
$ 19.5万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8766265
关键词：
Address Age Age-Months Animals Anthropometry Behavior Behavior assessment Beverages Birth Breast Feeding California Cereals Characteristics Child Childhood Clinical assessments Computerized Medical Record Coupled Data Data Analyses Databases Diabetes Mellitus Diabetes prevention Diagnosis Diet Habits Dietary Practices Dietary intake Distress Enrollment Evolution Exposure to Family Feeding behaviors Food Foundations Funding Future Gestational Diabetes Glucose Intolerance Goals Growth Health Health behavior Hospitals Human Individual Infant Infant Health Insulin Resistance Intake Intervention Juice Knowledge Lead Length Life Link Live Birth Longitudinal Studies Mediating Mediation Mediator of activation protein Metabolic Metabolic Diseases Methods Minority Mothers Non-Insulin-Dependent Diabetes Mellitus Obesity Oral Overweight Physical activity Postdoctoral Fellow Pregnancy Prevalence Prevention Prospective Studies Research Research Methodology Risk Risk Factors Sleep Stress Temperament Testing Time Weight Weight Gain Woman abstracting base cohort diabetes mellitus genetics feeding fetal high risk in utero infancy infant temperament insight maternal diabetes modifiable risk novel novel strategies nutrition obesity prevention offspring postnatal prenatal prevent prospective public health relevance rapid growth sedentary stressor successful intervention sugar sweetened beverage trait

项目摘要

DESCRIPTION (provided by applicant): Offspring of mothers with gestational diabetes mellitus (GDM) are more likely to develop obesity, glucose intolerance, insulin resistance, and type 2 diabetes because of intrauterine exposure to maternal diabetes, although postnatal feeding may modify risk. A 'difficult' temperament coupled with postnatal feeding practices, such as lack of breastfeeding, early complementary and sugary foods may jointly predispose infants to rapid growth and later obesity which are key risk factors for future metabolic disease. We propose a secondary data analysis of a high-risk cohort of GDM mother-infant pairs (71% minority) enrolled in the Study of Women, Infant Feeding and Type 2 Diabetes after GDM Pregnancy (SWIFT;R01HD050625). From 2008-2011, SWIFT enrolled 1,035 GDM mothers who delivered a singleton, live birth e35 weeks at Kaiser Permanente hospitals. Temperament, dietary intake (e.g., breastfeeding, dietary intake, sugar-sweetened beverages), and anthropometry were assessed among 363 infants in the first year of life. Leveraging these existing data, the proposed research will elucidate, for the first time, relationships between infat temperament and health behaviors, and their impact on infant growth in GDM offspring. The study aims are: Aim 1: To characterize the relation of "difficult" temperament (i.e., poorer distress to limitations, and less soothability) to infant growth during the first year of life, Aim2: To evaluate potential mediators of the association between "difficult temperament" and rapid infant growth (i.e., less breast feeding, cereal added to the bottle, early introduction of juice/foods, and high intake of sugar-sweetened foods/beverages), and Exploratory Aim 3: To determine whether difficult infant temperament is associated with overweight at age 2-4 years. A difficult infant temperament may introduce a host of additional stressors to new mothers in addition to the stress of GDM pregnancy. Our proposed research addresses novel hypotheses about temperament and modifiable risk factors that may inform strategies for early life obesity prevention.

描述（由申请人提供）：妊娠糖尿病（GDM）的母亲的后代更有可能发展肥胖，葡萄糖不耐症，胰岛素抵抗和2型糖尿病，这是由于春盐内暴露于母体糖尿病的原因，尽管后母体糖尿病可能会改变风险。一种“困难”的气质加上产后喂养实践，例如缺乏母乳喂养，早期互补和含糖食品，可能会共同使婴儿诱使婴儿快速生长和后来的肥胖症，这是未来代谢疾病的关键危险因素。我们提出了对GDM妊娠后女性，婴儿喂养和2型糖尿病研究的高危GDM母亲对（71％少数族裔）的二级数据分析（Swift; R01HD05050625）。从2008年至2011年，Swift招募了1,035个GDM母亲，他们在Kaiser Permanente Hospitals分娩了单身人士，现场出生E35周。气质，饮食摄入量（例如，母乳喂养，饮食摄入量，糖粉饮料）和人体测定法在生命的第一年中评估了363名婴儿。拟议的研究利用这些现有数据，将首次阐明性格与健康行为之间的关系及其对GDM后代婴儿增长的影响。 The study aims are: Aim 1: To characterize the relation of "difficult" temperament (i.e., poorer distress to limitations, and less soothability) to infant growth during the first year of life, Aim2: To evaluate potential mediators of the association between "difficult temperament" and rapid infant growth (i.e., less breast feeding, cereal added to the bottle, early introduction of juice/foods, and high intake of sugar-sweetened foods/beverages),和探索目的3：确定困难的婴儿气质是否与2-4岁的超重有关。除GDM妊娠的压力外，一个困难的婴儿气质可能会给新妈妈带来许多其他压力。我们提出的研究介绍了有关气质和可修改风险因素的新假设，这些假设可能为预防早期肥胖的策略提供依据。