Collaborative Research to Validate Biomarkers of Pediatric ARDS

验证儿科 ARDS 生物标志物的合作研究

基本信息

批准号：
10056715
负责人：
Patrick Sean McQuillen
金额：
$ 27.22万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-24 至 2020-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10056715
关键词：
Address Adult Adult Respiratory Distress Syndrome Basic Science Biological Markers Biomedical Research Blood Brain Injuries California Caring Child Childhood Clinical Clinical Data Clinical Research Clinical Trials Coagulation Process Complex Counseling Coupled Critical Care Critical Illness Critically ill children DNA Data Disease Enrollment Environment Funding Genetic Markers Genotype Goals Health Technology Healthcare Hematopoietic Stem Cell Transplantation Hospitals Hour Individual Infant Inflammation Inflammatory Infrastructure Intensive Care Intervention Knowledge Lead Leadership Life Measures Mediator of activation protein Medical center Medicine Modeling Molecular Multi-Institutional Clinical Trial National Heart, Lung, and Blood Institute National Institute of Child Health and Human Development Neonatal Organ failure Outcome Pathogenicity Pathway Analysis Pathway interactions Patients Pediatric Acute Respiratory Distress Syndrome Pediatric Hospitals Pediatric cohort Plasma Plasma Proteins Population Positioning Attribute Productivity Recording of previous events Research Research Personnel Resources Risk Risk Factors San Francisco Site Specific qualifier value Standardization Technology Testing Thrombosis Tidal Volume Time Translational Research Universities biomedical resource care systems clinical research site cost design evidence base genetic variant high risk improved outcome inflammatory marker insight lung injury mortality novel novel therapeutics outcome prediction pediatric department pediatric patients predictive marker programs prospective public health relevance research study response therapeutic target treatment trial ventilation

项目摘要

DESCRIPTION (provided by applicant): The NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN, UG1) was established in 2004 to address the following: (1) increased utilization of costly and complex pediatric critical care services and (2) lack of prospective clinical trials in pediatric critical care compared with adult and neonatal populations The primary Aim of this application is to join the CPCCRN as a clinical site, in order to expand our single center prospective observational cohort of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) through enrollment at multiple CPCCRN Sites. ARDS is a common cause of pediatric critical illness (30% of PICU mortalities). We propose to enroll 800 pediatric patients with ARDS and collect clinical data with plasma and genetic biomarkers of coagulation and inflammation. The data obtained will be essential for stratifying prospective clinical research trials and will provide insight into basic molecular and cellular disease mechanisms necessary for designing new treatments. UCSF Medical Center and Benioff Children's Hospital, the Department of Pediatrics and Division of Pediatric Critical Care Medicine have a long history of participation in ground breaking multicenter clinical research, as well as cutting edge individual investigator driven basic, translational and clinical research. This tradition, coupled with deep institutional resources for biomedical research, makes our center ideally positioned to contribute novel proposals to the consortium and participate fully in network-sponsored studies

描述（由申请人提供）：NICHD 儿科重症监护协作研究网络（CPCCRN，UG1）成立于 2004 年，旨在解决以下问题：(1) 增加对昂贵且复杂的儿科重症监护服务的利用，以及 (2) 缺乏前瞻性临床与成人和新生儿人群相比，在儿科重症监护中进行的试验本申请的主要目的是作为临床中心加入 CPCCRN，以扩大我们对儿科患者的单中心前瞻性观察队列通过在多个 CPCCRN 站点入组急性呼吸窘迫综合征 (ARDS) 是儿科危重疾病的常见原因（占 PICU 死亡率的 30%），我们建议入组 800 名 ARDS 儿科患者，并收集以下疾病的血浆和遗传生物标志物的临床数据。凝血和炎症的数据对于分层前瞻性临床研究至关重要。试验并将提供设计新疗法所需的基本分子和细胞疾病机制的见解，加州大学旧金山分校医学中心和贝尼奥夫儿童医院、儿科和儿科重症监护医学部在参与突破性多中心临床研究方面有着悠久的历史，以及尖端个人研究者驱动的基础、转化和临床研究这一传统，再加上生物医学研究的深厚机构资源，使我们的中心处于理想的位置，可以向联盟提出新颖的建议，并充分参与网络资助的研究。