Intraoperative functional mapping using infrared thermography

使用红外热成像技术进行术中功能定位

• 批准号: 10048125
• 负责人: Michael Iorga
• 金额: $ 4.6万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10048125
• 关键词: Agreement; Algorithms; Animals; Area; Behavior monitoring; Behavioral; Blood; Blood Vessels; Blood flow; Brain; Brain Mapping; Brain region; Cerebral cortex; Cognitive; Collection; Complex; Computers; Contralateral; Craniotomy; Data; Data Collection; Development; Devices; Electric Stimulation; Epilepsy; Excision; Future; Glioma; Goals; Gold; Hand; Human; Image; Imagery; Individual; Intractable Epilepsy; Language; Lead; Maps; Measures; Metabolism; Methods; Modeling; Monitor; Motion; Motor; Motor Cortex; Network-based; Neurologic Deficit; Neurosciences Research; Operating Rooms; Operative Surgical Procedures; Outcome; Patients; Pattern; Performance; Phase; Physiological; Postoperative Period; Predictive Value of Tests; Procedures; Property; Protocols documentation; Research; Resolution; Risk; Rodent; Safety; Seizures; Sensitivity and Specificity; Sensory; Shapes; Signal Transduction; Spatial Distribution; Speed; Stimulus; Surface; Surgeon; Task Performances; Techniques; Temperature; Testing; Thermography; Time; Vibrissae; Vision; Work; awake; barrel cortex; base; cohort; computerized data processing; design; imaging approach; improved; independent component analysis; interest; laptop; malformation; neurosurgery; neurovascular; neurovascular coupling; preservation; relating to nervous system; response; spatiotemporal; temporal measurement; tool; tumor; virtual reality

PROJECT SUMMARY Functional activation of the cerebral cortex creates a robust increase in local temperature by increasing blood flow and metabolism. Changes in surface brain temperature while an awake patient performs a motor, sensory, or language task can be used to infer spatial patterns of activity. Awake neurosurgery is used in the management of drug-resistant epilepsy, glioma, and neurovascular malformation, in order to localize seizure and/or physiologic activity. Protection of key functional areas is imperative to avoiding postoperative neurologic deficits. Currently, direct electrical stimulation (DES) is the most commonly used method of intraoperative surgical mapping, which identifies functionally critical brain regions so they are not resected. However, DES is low spatial resolution (~1 cm), may provoke seizures, and can only test one area at a time. This project investigates a new method of intraoperative functional mapping based on infrared thermography, which is high resolution (~100 micron) and simultaneously monitors the all exposed brain regions without risk for seizures. The device will be tested on the rodent whisker barrel cortex following awake craniotomy. Subsequently glioma patients will be studied, as tumors have relatively static impact on brain temperature compared to epileptogenic foci and vascular malformations. Preliminary data in a motor mapping case shows strong thermal activation of contralateral motor cortex, and strong agreement with DES. Aim 1 will establish the thermal signature of cortical activation during awake craniotomy. We will optimize the infrared recording procedure within the surgical workflow, as to maximize signal collection and quality while minimizing treatment interference. A mobile tripod will stabilize the infrared camera, which is connected to a laptop computer. The computer will monitor and collect behavioral data via adjunct surgical devices. Patient tasks currently used in DES will be adapted for thermographic recording. Aim 2 will leverage the high temporal resolution of infrared thermography for mapping brain networks. Independent components analysis will decompose the thermal activity into discrete, independent patterns which correspond to brain networks. The connectivity patterns of these regions may be analyzed to extract phase information. Features of the network activation signal will then be tested for predictive value of DES outcomes. If successful, this project will create a new method for intraoperative functional mapping during awake neurosurgery. Future work will integrate preoperative functional mapping information into the thermal mapping procedure. Ultimately, we hope to improve the precision of intraoperative brain mapping, in order to increase the safety and efficacy of surgery for patients with drug-resistant epilepsy, glioma, and neurovascular malformations.

项目摘要 大脑皮质的功能激活通过增加血液而增加了局部温度 流动和新陈代谢。表面大脑温度的变化，而清醒患者执行电动机，感觉， 或语言任务可用于推断活动的空间模式。清醒神经外科用于 抗药性癫痫，神经胶质瘤和神经血管畸形的治疗，以定位癫痫发作 和/或生理活动。保护关键功能区域对于避免术后神经系统至关重要 缺陷。当前，直接电刺激（DES）是术中最常用的方法 手术映射，标识了功能上关键的大脑区域，因此未切除它们。但是，des是 低空间分辨率（〜1厘米）可能会引起癫痫发作，并且一次只能测试一个区域。这个项目 研究一种基于红外热成像的新方法的术中功能映射方法，该方法很高 分辨率（〜100微米）并同时监测所有暴露的大脑区域，而没有癫痫发作的风险。 醒颅切开后，该设备将在啮齿动Whisker枪管皮层上进行测试。随后进行神经胶质瘤 将研究患者，因为与癫痫发作相比，肿瘤对脑温有相对静态的影响 焦点和血管畸形。电机映射案例中的初步数据显示出强烈的热激活 对侧运动皮层和与DES的强烈一致。 AIM 1将建立热签名 清醒颅骨切开术期间的皮质激活。我们将优化在此内的红外记录过程 手术工作流程，以最大程度地收集信号和质量，同时最大程度地减少治疗干扰。一个 移动三脚架将稳定连接到笔记本电脑的红外摄像头。计算机会 通过辅助手术设备监视和收集行为数据。目前在DES中使用的患者任务将是 适用于热量记录。 AIM 2将利用红外热力计的高时间分辨率 用于映射大脑网络。独立的组件分析将将热活动分解为 离散的独立模式与大脑网络相对应。这些地区的连通性模式 可以分析以提取相位信息。然后将测试网络激活信号的功能 DES结果的预测价值。如果成功，该项目将为术中创建一种新方法 醒着神经外科手术期间的功能映射。未来的工作将整合术前功能映射 信息到热映射过程中。最终，我们希望提高术中的精度 为了提高耐药性癫痫患者手术的安全性和功效，以提高脑图 神经胶质瘤和神经血管畸形。