Childhood Adversity, Biopsychosocial Pathways, and Telomere Length in Adolescence

童年逆境、生物心理社会途径和青春期端粒长度

• 批准号: 10066463
• 负责人: Jodi Ford
• 金额: $ 37.67万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10066463
• 关键词: 11 year old; Accounting; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Area; Biological; Biological Markers; Biological Testing; Birth; Caregivers; Cell Aging; Cellular Phone; Cellular Stress; Censuses; Characteristics; Child; Childhood; Chromosomes; Chronic Disease; Cohort Studies; Communities; Data; Data Analyses; Development; Disease; Exposure to; Family; Funding; Future; Geography; Hair; Health; Home environment; Hydrocortisone; Individual; Intervention; Length; Life; Life Cycle Stages; Linear Regressions; Location; Longevity; Measures; Mediating; Mental Health; Mission; Modeling; Neighborhoods; Normalcy; Parents; Pathway interactions; Pattern; Personal Satisfaction; Psychological Stress; Reporting; Research; Research Personnel; Risk; Safety; Saliva; Sampling; Schools; Source; Stress; Structure; Subgroup; Telomere Shortening; Testing; Time; United States National Institutes of Health; Violence; Youth; adolescent health; adverse childhood events; aged; anxiety symptoms; biopsychosocial; childhood adversity; data space; depressive symptoms; early childhood; epigenetic regulation; experience; high risk; hypothalamic-pituitary-adrenal axis; indexing; middle childhood; novel; peer; physical conditioning; prevent; psychologic; psychological distress; psychological symptom; secondary analysis; sex; socioeconomic disadvantage; statistics; suburb; telomere; therapy development

Summary Both adverse childhood experiences (ACEs) and shorter telomere length (TL) have been associated with chronic disease in adulthood, however, few researchers have examined effects of ACEs on TL early in the life course or at sensitive periods in development, limiting opportunities for earlier and/or developmentally timed intervention. Additionally, studies focused on hypothesized biological and psychological mechanisms through which ACEs contribute to shortening of telomeres are limited. Moreover, the effect of contextual exposures outside of adolescents' neighborhood on TL has not been examined. In our previous research, we found that adolescents spend 35% of their waking time outside of their residential census tract, thus the effect of contextual exposures encompassing adolescents' neighborhood and other routine locations (e.g. school, peers, activities, etc.), known as their “activity space,” on TL has not been examined. Our study will add to the evidence on the relationship between ACEs and TL in adolescence by examining ACEs occurring at specific developmental periods (birth, early childhood, middle childhood, and adolescence) as well as cumulatively. We will also investigate biological (HPA axis; hair cortisol) and psychological (depressive and anxious symptoms) stress pathways through which ACEs may affect TL. Moreover, we will also use novel activity space data to examine relationships between adolescents' exposure to contemporary individual and sociospatial adversity and TL. Our specific aims are to examine: patterns of ACEs occurring across childhood and adolescence (birth, 0-5 years, 6-10 years, and 11 to 17 years) and their effect on adolescent biological stress, psychological distress, and TL; relationships between biological stress and TL and psychological distress and TL; the extent to which biological stress and psychological distress mediate the relationship between patterns of child/adolescent ACEs and adolescent TL; patterns of contemporary individual and activity space ACEs during adolescence and their effect on adolescent biological stress, psychological distress, and TL, accounting for ACEs prior to age 11 years; and the extent to which biological stress and psychological distress mediate the relationship between patterns of contemporary individual and activity space ACEs and adolescent TL, accounting for ACEs prior to age 11 years. In the analysis of each aim we will explore sex as a moderator of the hypothesized relationships. The study is a secondary analysis of data collected from two NIH funded studies of 1,018 adolescents. Study variables will be constructed from existing data and analyzed using descriptive statistics for data distribution, identify outliers, conduct data transformation if needed to achieve normality, and summarize subject characteristics. We will use latent class analysis and multiple linear regressions models for hypothesis testing. Our approach will identify sub-groups of ACEs across childhood and adolescence that increase adolescents' risk for shorter TL as well as the extent to which biological and psychological stress pathways explain these relationships. The findings will inform the development of interventions targeted to specific exposure patterns and the effects of stress on TL.

概括 不良的童年经历（ACE）和较短的端粒长度（TL）都与慢性有关 然而，成年后，很少有研究人员检查了ACE对生命课程初期TL的影响或 在敏感时期开发时期，限制了早期和/或发展定时干预的机会。 此外，研究着重于假设的生物学和心理机制，通过这些机制 促进端粒的缩短是有限的。此外，背景暴露的影响 尚未检查青少年在TL上的社区。在我们以前的研究中，我们发现青少年 在居民人口普查之外花费35％的清醒时光，因此上下文暴露的影响 包括青少年的社区和其他常规位置（例如学校，同龄人，活动等），已知 作为其“活动空间”，尚未检查TL上的“活动空间”。我们的研究将增加有关关系的证据 通过检查在特定发育时期发生的ACE（出生， 童年，中年和青春期以及累积。我们还将研究生物学 （HPA轴；头发皮质醇）和心理（抑郁和焦虑症状）压力途径 ACE可能会影响TL。此外，我们还将使用新颖的活动空间数据来检查 青少年接触当代个人和社会空间广告和TL。我们的具体目的是 检查：在童年和青少年之间发生ACE的模式（出生，0-5岁，6-10岁，11岁 17年）及其对青春期生物压力，心理困扰和TL的影响；之间的关系 生物压力和TL和心理困扰以及TL；生物压力和 心理困扰介导了儿童/青少年王牌与青少年TL的模式之间的关系； 青少年期间现代个人和活动空间ac的模式及其对青少年的影响 生物压力，心理困扰和TL，在11岁之前占王牌；以及 哪种生物压力和心理困扰介导了当代模式之间的关系 在分析中，个体和活动空间ac和青少年的TL，在11岁之前说明ace。 在每个目标中，我们将探索性别作为假设关系的主持人。该研究是次要的 从1,018名青少年的两项NIH资助的研究中收集的数据分析。研究变量将被构造 从现有数据中使用描述性统计数据进行数据分配，识别异常值，进行数据进行分析 如果需要，转换以达到正态性和摘要主题特征。我们将使用潜伏类 分析和多个用于假设检验的线性回归模型。我们的方法将确定 跨越童年和青少年的ACE会增加青少年较短TL的风险以及 哪种生物和心理压力途径可以解释这些关系。调查结果将告知 针对特定暴露模式的干预措施的发展以及应力对TL的影响。