Program 15: Cancer Cell Biology

项目 15：癌细胞生物学

基本信息

批准号：
10062936
负责人：
JEFFREY W HARPER
金额：
$ 7.37万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-10 至 2021-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10062936
关键词：
Area Attention Basic Cancer Research Basic Science Biochemical Biology CRISPR/Cas technology Cancer Center Cancer Etiology Catchment Area Cells Cellular biology Cessation of life Chemicals Clinic Clinical Investigator Clinical Trials Clinical effectiveness Collaborations Dependence Development Disease Drug Industry Drug Targeting Emerging Technologies Enzymatic Biochemistry Epigenetic Process Fostering Functional disorder Funding Generations Genetic Genome Stability Genome engineering Genomics Goals Home Human Genome Image In Vitro Institution Malignant Neoplasms Malignant neoplasm of lung Metabolic Methods Microfluidics Mission Multiple Myeloma Mutation Neoplasm Circulating Cells Nodal Non-Small-Cell Lung Carcinoma Normal Cell Paper Pathogenesis Pathway interactions Patients Peer Review Grants Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacologic Substance Pharmacology Process Proteomics Publications Publishing Research Personnel Resistance Resolution Role Science Scientist Signal Pathway Signal Transduction Technology Thalidomide Therapeutic Translating Tumor Cell Invasion Tumor-Derived Work analytical method anticancer research base biomarker identification cancer biomarkers cancer cachexia cancer cell cancer genome cell behavior chromothripsis clinical translation cost design drug development epigenetic regulation first-in-human fundamental research genome sequencing genome-wide homologous recombination inhibitor/antagonist inter-institutional light microscopy meetings member metabolomics neoplastic cell new technology novel novel anticancer drug patient screening personalized therapeutic programs reconstitution recruit resistance mechanism single cell analysis small molecule structural biology technology development tool translational scientist treatment response

项目摘要

Cancer Cell Biology Program Project Summary / Abstract The mission of the Cancer Cell Biology Program is to facilitate basic cancer research and accelerate the application of basic science discoveries in the clinic. The Program has three Specific Aims: 1) To elucidate the pathophysiology of cancer; 2) To support the development and dissemination of new technologies for cancer research; and 3) To facilitate the clinical translation of basic scientific discoveries. The program has 97 members, representing seven DF/HCC institutions and 17 academic departments. In 2014 peer-reviewed grant funding attributed to the Program was $23.8 million in total costs from the NCI and $31.9 million from other sponsors. During the current funding period, Cancer Cell Biology Program members published 1,769 cancer- relevant papers. Of these 24% were inter-institutional, 9% were intra-programmatic, and 34% were inter- programmatic collaborations between two or more DF/HCC members. Overall, when counted once, 27% of DF/HCC publications were inter-programmatic collaborations.

癌细胞生物学项目项目概要/摘要癌细胞生物学计划的使命是促进基础癌症研究并加速基础科学发现在临床中的应用。该计划有三个具体目标： 1) 阐明癌症的病理生理学； 2）支持癌症新技术的开发和传播研究; 3) 促进基础科学发现的临床转化。该计划有97 成员，代表 7 个 DF/HCC 机构和 17 个学术部门。 2014年同行评审资助该计划的总费用为 2,380 万美元，来自 NCI，3,190 万美元来自其他机构赞助商。在当前资助期间，癌细胞生物学计划成员发表了 1,769 篇癌症- 相关论文。其中 24% 是机构间的，9% 是项目内的，34% 是机构间的。两个或多个 DF/HCC 成员之间的计划性合作。总体而言，如果计算一次，27% DF/HCC 出版物是跨项目合作。