The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury

营养在酒精引起的器官损伤的发生/进展中的作用

• 批准号: 10056411
• 负责人: CRAIG J. MCCLAIN
• 金额: $ 143.7万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10056411
• 关键词: Alcohol abuse; Alcoholic Liver Diseases; Alcohols; Brain; Broccoli - dietary; Butyrates; Cause of Death; Chronic; Collaborations; Communities; Country; Development; Dietary Fats; Dietary Intervention; Education; Enhancers; Epigenetic Process; Ethanol; FDA approved; Faculty; Feces; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fostering; Functional disorder; Funding; Future; Goals; Grant; Health Care Costs; Impairment; Individual; Industry; Injury; Institution; Interdisciplinary Study; Intervention; Intestines; Knowledge; Lactobacillus; Lead; Lipids; Mediating; Mediator of activation protein; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neural Crest Cell; Nutritional; Organ; Pathogenesis; Prevention; Prevention approach; Prevention therapy; Preventive; Probiotics; Proteomics; Research; Research Personnel; Resources; Role; School Dentistry; Signal Transduction; Sulforaphane; Therapeutic Intervention; United States; United States National Institutes of Health; Universities; Volatile Fatty Acids; alcohol abuse therapy; alcohol exposure; alcohol intervention; alcohol research; alcohol use disorder; base; cofactor; cohesion; college; exosome; gut bacteria; gut-liver axis; high school; improved; inflammatory disease of the intestine; intestinal barrier; liver inflammation; metabolome; metabolomics; mortality; mouse model; multidisciplinary; nanoparticle; new therapeutic target; novel; nutrition; organ injury; prevent; teratogenesis; therapeutic effectiveness; therapeutic target

The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments and 6 colleges. The Specific Aims of the ULARC are to: 1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury; 2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury; 3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the mechanistic research of the ULARC; and 4) disseminate knowledge/interventions to the scientific and lay communities. We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1 (Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol- induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD. Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and nutritional interventions on alcohol-induced organ injury.

路易斯维尔大学酒精研究中心 (ULARC) 的成立是为了充当 区域/国家资源，以开展跨学科合作研究营养的作用 酒精引起的器官损伤的辅助因子，并作为预防/治疗的可能治疗干预措施 这种器官损伤。该中心的营养和酒精引起的器官损伤主题在同行中是独一无二的。 酒精中心。该方法具有高度转化性。我们的调查员包括来自 13 个系的教师 和6所学院。 ULARC 的具体目标是： 1）进行/促进营养和酒精引起的器官损伤的跨学科研究； 2) 作为营养和酒精引起的器官损伤研究的区域/国家资源； 3）根据酒精引起的器官损伤制定潜在的治疗目标/干预措施 ULARC的机理研究；和 4) 向科学界和非专业界传播知识/干预措施。 我们将探讨营养和酒精滥用在酒精诱发的器官发育中的相互作用 功能障碍，我们将评估各种潜在的营养预防/治疗干预措施。项目1 (Kirpich/McClain) 评估膳食脂肪在 ALD 发病机制中的作用；项目 2 (Barve) 评估酒精- 诱导肠道：肝轴的表观遗传改变。项目 3（陈）将阐明其机制 增强子介导乙醇诱导的神经嵴细胞发育障碍和致畸 用于预防 FASD 的独特外泌体治疗。项目 4（冯）研究了 益生菌、鼠李糖乳杆菌 GG (LGG) 在 ALD 中肠道：肝轴上的作用。 这些项目共同形成了一种有凝聚力和互动的方法来研究营养和营养的影响 营养干预对酒精引起的器官损伤。