Assessing Environmental Exposures to Persistent Organic Pollutants in Assisted Living Facilities

评估辅助生活设施中持久性有机污染物的环境暴露

• 批准号: 10022518
• 负责人: Joseph R. Shaw
• 金额: $ 23.78万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2023-10-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022518
• 关键词: Address; Affect; Aging; Air; Aromatic Polycyclic Hydrocarbons; Assisted Living Facilities; Biological Markers; Biological Monitoring; Cardiovascular Diseases; Censuses; Central obesity; Chemical Exposure; Chemicals; Construction Materials; Country; Data; Data Collection; Deterioration; Development; Dust; Elderly; Electronics; Environment; Environmental Exposure; Environmental Health; Environmental Pollution; Esters; Europe; European; Exposure to; Fire - disasters; Flame Retardants; Foundations; Furniture; Future; Goals; Hazardous Chemicals; Health; Health care facility; Household; Hypertension; Indiana; Individual; Indoor environment; Intervention; Knowledge; Long-Term Care; Measurement; Measures; Metabolic Diseases; Mission; Nail plate; Nitrogen Dioxide; Non-Insulin-Dependent Diabetes Mellitus; Organic Chemicals; Organophosphates; Ozone; Participant; Particulate Matter; Pest Control; Pesticides; Physiological; Policies; Polychlorinated Biphenyls; Population; Population Group; Prevalence; Production; Public Health; Quality of life; Regulation; Research; Risk; Safety; Sampling; Silicones; Source; System; Techniques; Time; Translations; United States; United States National Institutes of Health; Vulnerable Populations; Work; base; cohort; epidemiology study; exposed human population; human old age (65+); improved; indoor exposure; innovation; novel; organochlorine pesticide; persistent organic pollutants; pressure; prevent; programs; recruit; respiratory; therapy development

Project Summary Abstract There is a fundamental gap in understanding how indoor exposures to environmental contaminants affect the health of older adults living or spending time in senior care facilities. Continued existence of this gap represents an important problem, because until it is filled, development of interventions and regulations to reduce health risks associated with indoor exposures in senior care facilities will remain unattainable. The long-term goal of our research program is to examine risks associated with exposure to persistent organic pollutants (POPs) in senior care facilities for future development and implementation of interventions to prevent or reduce these risks. Our objective in this application is to determine the connection between ambient conditions, personal exposures, and biomarkers of exposure to POPs among the residents of senior care facilities located in Indiana. We hypoth- esize that there is a significant association between ambient conditions, personal exposures, and biomarkers of exposure in senior care facilities. Our rationale for the proposed study is that the knowledge obtained through this research will advance our understanding of the impacts of indoor exposure to POPs on health of the resi- dents of senior care facilities. We will use innovative non-invasive data collection techniques to pursue the fol- lowing specific aims: 1) Determine ambient levels of five POP groups (polychlorinated biphenyls, organochlorine pesticides, polycyclic aromatic hydrocarbons, brominated flame retardants, and organophosphate esters) in sen- ior care facilities in Indiana via air and dust sampling; 2) Estimate personal exposures to target chemicals among residents of the facilities using silicone wristbands as personal passive samplers; 3) Determine biomarkers of exposure to POPs through analysis of nails, a non-invasive biomonitoring technique. The study will recruit 100 residents of senior care facilities located in Indiana (10 facilities with 10 participants per facility) for the exposure assessments. We will examine indoor exposures through air and dust sampling in participants' rooms. We will use silicone wristbands as innovative passive samplers of personal exposures and we will measure biomarkers of POPs in nail clippings collected from participants. This approach is innovative because it examines a previ- ously unrecognized exposure to POPs in an understudied settings with particularly vulnerable population, and because it employs silicone wristbands and nails as novel, simple, and non-invasive ways to measure personal exposures and biomarkers of exposure. The proposed research is significant because accomplishing these spe- cific aims will advance our understanding of how exposure to POPs may impact health of a vulnerable population of older adults. This information will provide an essential foundation for subsequent applications to investigate and reduce risks associated with this exposure through epidemiological studies and targeted interventions.

项目摘要摘要 理解室内暴露于环境污染物如何影响该室内的基本差距 老年人的健康生活或在高级护理设施中度过的时间。该差距的持续存在代表 一个重要的问题，因为在填补之前，制定干预措施和法规以减少健康 与高级护理机构中室内暴露相关的风险将无法实现。长期目标 我们的研究计划是检查与暴露于持续的有机污染物（POP）相关的风险 用于未来开发和实施干预措施以防止或降低这些风险的高级护理设施。 我们在此应用程序中的目标是确定环境条件，个人暴露， 以及位于印第安纳州高级护理设施居民中流行音乐的生物标志物。我们假设 esize认为，环境条件，个人暴露和生物标志物之间存在显着关联 高级护理设施的接触。我们对拟议研究的理由是通过 这项研究将使我们对室内暴露对POP的影响对居民健康的影响的理解 - 高级护理设施的凹痕。我们将使用创新的非侵入性数据收集技术来追求。 降低特定目的：1）确定五个流行群的环境水平（多氯联苯，有机氯 农药，多环芳烃，溴化阻燃剂和有机磷酸酯酯） 印第安纳州的IOR护理设施通过空气和灰尘采样； 2）估计个人暴露于目标化学物质 设施的居民使用硅胶腕带作为个人被动采样器； 3）确定生物标志物 通过分析指甲（一种非侵入性生物监测技术）暴露于POP。该研究将招募100 印第安纳州高级护理设施的居民（10个设施，每个设施10个参与者）进行接触 评估。我们将通过参与者房间中的空气和灰尘采样检查室内暴露。我们将 使用硅胶腕带作为个人暴露的创新被动抽样，我们将测量生物标志物 从参与者收集的指甲剪剪中的流行音乐。这种方法具有创新性，因为它检查了一个先前 在有特别脆弱人群的经过研究的研究中，无法识别出对POP的暴露，并且 因为它使用硅胶腕带和指甲作为新颖，简单和非侵入性的方法来衡量个人 暴露和生物标志物的暴露。拟议的研究很重要，因为完成这些SPE- Cific Aims将提高我们对POPS暴露可能影响脆弱人群健康的理解 老年人。该信息将为后续申请提供基础 并通过流行病学研究和针对性的干预措施降低与这种暴露有关的风险。