Absolute Measurement of Cerebral Blood Flow Using Diffuse Optics

使用漫射光学器件绝对测量脑血流量

• 批准号: 7477238
• 负责人: Turgut Durduran
• 金额: $ 22.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477238
• 关键词: Acetazolamide; Address; Adult; Agreement; Algorithms; Area; Arteries; Beds; Biological; Blood; Brain; Breathing; Caffeine; Calibration; Carbon Dioxide; Cations; Central Nervous System Diseases; Cerebrovascular Circulation; Cerebrum; Classification; Clinical; Clinical Management; Clinical Research; Clinical Trials; Complex; Computer Simulation; Computer software; Condition; Congenital Heart Defects; Contrast Media; Craniocerebral Trauma; Data; Development; Diagnostic; Diffuse; Diffusion; Disease; Disease Management; Doppler Ultrasound; Equation; Generic Drugs; Goals; Head; Hemoglobin; Hemorrhage; Heterogeneity; Human; Individual; Intake; Intensive Care; Intervention; Invasive; Libraries; Localized; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Medical; Methods; Modality; Modeling; Near-Infrared Spectroscopy; Neuraxis; Numbers; Optics; Organ; Patients; Photons; Physiological; Positron-Emission Tomography; Procedures; Property; Range; Recruitment Activity; Regulation; Relative (related person); Reproducibility; Research; Scheme; Side; Signal Transduction; Simulate; Source; Spectrum Analysis; Spin Labels; Standards of Weights and Measures; Stroke; Techniques; Technology; Testing; Time; Tissues; Training; Urination; Xenon; acute stroke; base; clinical application; cohort; day; design; design and construction; detector; experience; improved; in vivo; instrument; instrumentation; man; neonate; programs; research study; tissue phantom; tool

DESCRIPTION (provided by applicant): Clinical interventions in central nervous system (CNS) disease management base decisions on primarily deductions from a variety of secondary information and on the individual or collective experience of clinicians rather than direct measurements of brain function, and in particular cerebral blood flow (CBF). A non-invasive, continuous, bed-side instrument for measurement of CBF in the micro-vasculature would, in fact, be highly desirable for management of a variety of CNS disorders such as stroke, hemorrhage, and head trauma. Diagnostics in current use have limitations. For example, available modalities deliver either insufficient information (e.g. transcranial Doppler Ultrasound measurement of velocity within selected arteries) or are relatively inaccessible (Xenon inhalation CT, arterial spin labeling MRI, PET). The premise of this proposal is that a newly developed optical technique can be used to measure absolute CBF. Diffuse correlation spectroscopy (DCS) offers new, non-invasive medical diagnostic tools whose capabilities for relative measurements have recently been demonstrated in functional activation studies of intact human brain. Further developments in DCS are expected to have a clinical impact. To that end, this proposal addresses the shortcomings of DCS in a systematic way. Questions such as; ``What is the biological origin of the signal?'', ``Which tissue volume is being probed?'' and ``Can the absolute, cortical CBF be estimated?'' are addressed via computer simulations, experiments on tissue simulating phantoms and via in vivo studies. If successful, pilot clinical trials and further development of the instrumentation will follow. We expect that in a short time period, the clinical utility of this technology will be established. Another side-benefit of this project will be that other clinical applications in other diseases and organs will be feasible. Clinical interventions in central nervous system (CNS) disease management base decisions on primarily deductions from a variety of secondary information and experience of clinicians rather than direct measurements of cerebral blood flow (CBF). A non-invasive, continuous, bed-side instrument for measurement of CBF in the micro-vasculature would be highly desirable for management of a variety of CNS disorders such as stroke, hemorrhage, and head trauma. The proposed optical technique will take a big step towards fullfiling this void.

描述（由申请人提供）：中枢神经系统 (CNS) 疾病管理的临床干预决策主要基于各种次要信息的推论以及临床医生的个人或集体经验，而不是直接测量脑功能，特别是脑功能。血流量（CBF）。事实上，用于测量微脉管系统中 CBF 的非侵入性、连续性、床边仪器对于治疗各种中枢神经系统疾病（例如中风、出血和头部外伤）是非常理想的。当前使用的诊断有局限性。例如，现有的方法要么提供的信息不足（例如，经颅多普勒超声测量选定动脉内的速度），要么相对难以获得（氙气吸入 CT、动脉自旋标记 MRI、PET）。该提案的前提是新开发的光学技术可用于测量绝对CBF。漫相关光谱 (DCS) 提供了新型非侵入性医疗诊断工具，其相对测量功能最近已在完整人脑的功能激活研究中得到证明。 DCS 的进一步发展预计将产生临床影响。为此，本提案系统地解决了 DCS 的缺点。诸如此类的问题； “信号的生物起源是什么？”、“正在探测哪个组织体积？”和“可以估计绝对的皮层 CBF？”通过计算机模拟和组织模拟体模实验来解决并通过体内研究。如果成功，将进行试点临床试验并进一步开发仪器。我们预计在短时间内，该技术的临床应用将得以确立。该项目的另一个附带好处是其他疾病和器官的其他临床应用将是可行的。中枢神经系统（CNS）疾病管理的临床干预决策主要基于临床医生的各种二手信息和经验的推论，而不是直接测量脑血流量（CBF）。一种用于测量微脉管系统中 CBF 的非侵入性、连续性、床边仪器对于治疗各种中枢神经系统疾病（如中风、出血和头部外伤）来说是非常理想的。所提出的光学技术将朝着填补这一空白迈出一大步。