Establishing the Pathways Between Diabetes and Cardiac Dysfunction: Epidemiology, Biomarkers, and Imaging

建立糖尿病和心脏功能障碍之间的途径：流行病学、生物标志物和影像学

基本信息

批准号：
10039436
负责人：
Justin Basile Echouffo Tcheugui
金额：
$ 19.82万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10039436
关键词：
Adult Animals Atherosclerosis Risk in Communities Biological Markers Biostatistical Methods Blood Circulation Cardiac Cardiovascular Diseases Cardiovascular system Characteristics Clinic Clinical Research Communities Competence Complement Coronary Coronary Arteriosclerosis Data Data Collection Development Diabetes Mellitus Diagnosis Doctor of Philosophy EFRAC Early Diagnosis Elderly Endocrinology Endothelin-1 Endothelium Epidemiologic Methods Epidemiology Five-Year Plans Functional disorder Funding Future Goals Grant Heart failure Hospitals Human Hyperglycemia Image Imaging Techniques Incidence Individual Inflammation Inflammatory Injury Intervention Investigation Lead Link Measures Mentored Patient-Oriented Research Career Development Award Mentors Metabolism Microvascular Dysfunction Molecular Myocardial Myocardial dysfunction Non-Insulin-Dependent Diabetes Mellitus Participant Pathogenicity Pathology Pathway interactions Patient Recruitments Patients Performance Phenotype Physicians Plasma Plasminogen Activator Inhibitor 1 Play Positioning Attribute Positron-Emission Tomography Prediabetes syndrome Prevention Preventive Prospective cohort Proteins Proteomics Research Research Design Research Proposals Risk Sampling Scientist Series Statistical Models Stress Structure System Techniques Training United States National Institutes of Health Universities Ventricular Dysfunction Ventricular Remodeling Work aptamer base cardiovascular risk factor career clinical biomarkers cohort design diabetic endothelial dysfunction experience follow-up heart imaging imaging approach imaging biomarker improved innovation medical schools metabolic imaging myocardial injury novel novel marker preservation prevent professor programs recruit research study skills

项目摘要

PROJECT SUMMARY/ABSTRACT Justin Echouffo Tcheugui, MD, PhD is an Assistant Professor in the Division of Endocrinology at the Johns Hopkins University School of Medicine. He seeks a K23 Mentored Patient-Oriented Research Career Development Award to obtain essential skills and mentored research experience for an independent career as a physician scientist in the field of metabolism and cardiovascular diseases. His research proposal details a five-year plan, with an overarching goal of achieving a clinical, biomarker and imaging characterization of diabetes-related cardiac dysfunction including an identification of key pathways of pathogenicity, in a large community-based cohort of black and white adults, and in a clinic-based sample of individuals with diabetes. The specific aims of the research are: 1) Assess the association of hyperglycemia with longitudinal changes in cardiac structure and function, and incidence and progression of heart failure and its subtypes; 2) Identify novel molecular pathways underlying the occurrence of diabetes-related cardiac dysfunction, using a plasma proteomic approach; 3) Evaluate whether coronary microvascular disease is a specific marker of diabetes- related cardiac dysfunction, using a dual investigative approach including cardiac positron emission tomography (PET) and circulation biomarkers of microvascular dysfunction. This study will inform heart failure prevention and treatment among individuals with diabetes, as it may identify novel biomarkers associated with diabetes-related cardiac dysfunction that can enhance our understanding of pathophysiology and serve as potential targets for interventions in future studies. Concurrent to the proposed research, the applicant will have tailored, in-depth didactic and hands-on training in advanced epidemiologic and biostatistics methods, biomarker and proteomics research, and in cardiac PET as an investigative imaging technique, as well as develop expertise in the design and performance of clinical studies, by leading data collection in a new cohort. The acquired skills will fill key training gaps for the applicant, thereby positioning Dr. Echouffo Tcheugui for a successful independently funded research career. His long-term goals are to establish a research program aimed at advancing the understanding of cardiovascular complications in diabetes, and informing future strategies for cardiovascular risk prediction and prevention among individuals with diabetes.

项目概要/摘要 Justin Echouffo Tcheugui，医学博士、哲学博士是约翰斯医学院内分泌科助理教授霍普金斯大学医学院。他寻求 K23 指导的以患者为导向的研究职业发展奖获得独立职业所需的基本技能和指导研究经验代谢和心血管疾病领域的医学科学家。他的研究计划详细介绍了五年计划，总体目标是实现临床、生物标志物和成像特征糖尿病相关的心脏功能障碍，包括鉴定致病性的关键途径，在很大程度上基于社区的黑人和白人成年人队列，以及基于临床的糖尿病患者样本。该研究的具体目的是： 1) 评估高血糖与纵向变化的关系心脏结构和功能，以及心力衰竭及其亚型的发生率和进展； 2）识别小说使用血浆研究糖尿病相关心脏功能障碍发生的分子途径蛋白质组学方法； 3）评估冠状动脉微血管疾病是否是糖尿病的特异性标志物—— 相关的心脏功能障碍，使用双重研究方法，包括心脏正电子发射断层扫描（PET）和微血管功能障碍的循环生物标志物。这项研究将为心力衰竭提供信息糖尿病患者的预防和治疗，因为它可以识别与糖尿病相关的新生物标志物糖尿病相关的心脏功能障碍可以增强我们对病理生理学的理解并作为未来研究中干预措施的潜在目标。在进行拟议研究的同时，申请人将拥有高级流行病学和生物统计学方法的定制、深入的教学和实践培训，生物标志物和蛋白质组学研究，以及心脏 PET 作为一种研究成像技术，以及通过领导新队列的数据收集，培养临床研究设计和执行方面的专业知识。获得的技能将填补申请人的关键培训空白，从而使 Echouffo Tcheugui 博士能够胜任成功的独立资助的研究生涯。他的长期目标是建立一个研究计划旨在增进对糖尿病心血管并发症的了解，并为未来提供信息糖尿病患者心血管风险预测和预防的策略。