ARIC - JHU FIELD CENTER - DIVERSITY SUPPLEMENT

ARIC - JHU 野外中心 - 多样性补充

• 批准号: 10054600
• 负责人: JOSEF CORESH
• 金额: $ 23.38万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054600
• 关键词: ARIC; JHU; FIELD; CENTER; DIVERSITY

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam during 2011-2013. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Participation of the surviving cohort was 91, 82, 74, and 65% at each of the respective follow-up examinations. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical Cardiovascular Disease (CVD) events. Cohort contact was 84% at the last completed follow-up ending on December 31, 2013.

社区研究（ARIC）研究的动脉粥样硬化风险是在1985年开始的两个组成部分：基于社区的监视和一项前瞻性队列研究。社区监视旨在监测美国四个社区的住院心肌梗死（MI），致命性冠心病（CHD）的趋势：北卡罗来纳州福赛斯县；杰克逊，女士；明尼苏达州明尼阿波利斯的郊区；和马里兰州华盛顿县。在2005年增加了针对住院心力衰竭（HF）事件的监视。在城市，郊区和粗糙的环境中，选择了社区来提供四（4）个地理位置的数据。该队列研究旨在研究中年白人或非裔美国人成年人的动脉粥样硬化和临床动脉粥样硬化发展的危险因素和自然史。这项研究在15,792名白人或非裔美国人参与者最初年龄45-64岁，选定的参与者在研究的前十年（1987-1989，1990-1992，1993-1993-1995和1996-1998）接受了三年期临床检查，并在2011年 - 20113年进行了精神症状。自1988年以来，该队列每年都与该队列联系，并在2011年开始了半年度随访。截至2014年，已经在1,400多个出版物中提出了发现。参与者使用B模式超声检查颈动脉和popliteal动脉的B型超声检查参与者的证据，脚踝 - 野草指数的测量，视网膜摄影，以及在子集中，腹部主动脉CT和腹部主动脉ct和血压因子；建立和推定的实验室风险标志；社会经济，心理，行为和环境特征；和遗传因素。考试包括各种组件，并在2011 - 2013年期间的最新考试中添加了赠款资助的详细认知功能测试组件。已经为假定的生化危险因素分配了血液样本，并存储了病例对照研究。 DNA已被提取，并为候选基因，全基因组扫描，表达和其他 - 组学研究的淋巴细胞冷冻保存（可能永生化）。在每个相对随访检查中，生存队列的参与分别为91、82、74和65％。自基线以来，也已经每12个月与队列成员联系一次，以获取有关生命状况，当前居住，重大疾病或伤害的信息，并且在接触之间进行住院以识别临床心血管疾病（CVD）事件。在2013年12月31日结束的最后一次完成的随访中，队列联系人为84％。